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Gurunadhan, Deepa
- COX2 Inhibitory activity of Abutilon indicum-In Invitro Study
Authors
1 Undergraduate Student, Department of Pharmacology, Saveetha Dental College, SIMATS, Saveetha University Chennai, Tamilnadu, IN
2 Associate Professor, Department of Pharmacology, Saveetha Dental College, SIMATS, Saveetha University Chennai, Tamilnadu, IN
3 Professor, Department of Pedodontics & Preventive Dentistry, Saveetha Dental College, SIMATS, Saveetha University Chennai, Tamilnadu, IN
4 Professor, Department of Public Health Dentistry, Saveetha Dental College, SIMATS, Saveetha University Chennai, Tamilnadu, IN
Source
Indian Journal of Public Health Research & Development, Vol 10, No 11 (2019), Pagination: 3523-3526Abstract
Aim: To analyse the COX2 inhibitory activity of Abutilon indicum.
Objective: The main objective of this study is to analyse the COX2 inhibitory activity of Abutilon indicum.
Background: Prostaglandins are important mediators of the body’s response to pain and inflammation, and are formed from essential fatty acids found in cell membranes. This reaction is catalysed by cyclooxygenase, a membrane associated enzyme in two isoforms - COX-1 and COX-2. Abutilon indicum ,commonly known as the Indian mallow is well known for its therapeutic values and further study of its COX-2 inhibitory activity is beneficial.
Conclusion: Medicinal plants and shrubs which have little or no side effects have to be further investigated. Further study on its COX-2 inhibition will increase its therapeutic value also as an anti-inflammatory with added benefits
Keywords
Ethnomedicinal, Anti-Arthritic, COX2 Inhibition, Medicinal Uses, Prostaglandin.
- Glucose Uptake Potential in L6 Myotubes by Ficus racemosa
Authors
1 Undergraduate Student, Department of Pharmacology, Saveetha Dental College, SIMATS, Saveetha University Chennai, Tamilnadu, IN
2 Associate Professor, Department of Pharmacology, Saveetha Dental College, SIMATS, Saveetha University Chennai, Tamilnadu, IN
3 Professor, Department of Pedodontics & Preventive Dentistry, Saveetha Dental College, SIMATS, Saveetha University Chennai, Tamilnadu, IN
4 Associate Professor, Department of Microbiology, Saveetha Dental College, SIMATS, Saveetha University Chennai, Tamilnadu,, IN
5 Professor, Department of Public Health Dentistry, Saveetha Dental College, SIMATS, Saveetha University Chennai, Tamilnadu, IN
Source
Indian Journal of Public Health Research & Development, Vol 10, No 11 (2019), Pagination: 3527-3531Abstract
Introduction: Ficus racemosa is widely used in ayurvedic medicine in India, mostly as fruits and bark decoction to treat uncontrolled diabetes, the objective of this study is to study the uptake of glucose in L6 myotubes by Ficus racemosa.
Background: Diabetes is a common metabolic disease characterized by abnormally high plasma glucose levels, leasing to major complications, such as diabetic neuropathy, retinopathy and cardiovascular disease. Presently available oral hypoglycaemic agents exhibit several side effects. Therefore, there is a need for more effective oral antihyperglycemic agent, particularly those that normalize both insulin and glucose levels.
Method: Cell culture: L6, a mono layer myoblast culture (obtained from NCCS, Pune-Passageno-19) was cultured in the DMEM. In vitro glucose uptake activity: Glucose uptake assay was followed by the methodology of (Gupta et al).
Result: It was observed from the results that Ficus racemosa extract at different concentrations exhibited substantial degree of glucose uptake in skeletal muscle cells, which was compared with that of Standard Metformin. A maximum glucose uptake of 53% was observed for ficus 30mg/ml, whereas metformin exhibited 61% of glucose uptake. The IC50 of ficus extract and metformin was found to be 2.57mg/ml and 1.79mg/ml respectively.
Conclusion: From the study that was conducted above it can be concluded that Ficus racemosa had a better glucose uptake compared to the with that of Standard Metformin used by diabetic patients.
Keywords
Ficus racemose, Glucose, l6 Motube, Uptake, Myoblast.- Antibacterial Activity of Taxifolin Isolated from Acacia catechu Leaf Extract-An Invitro Study
Authors
1 Undergraduate Student, Department of Pharmacology, Saveetha Dental College, SIMATS, Saveetha University, Chennai, Tamilnadu, IN
2 Associate Professor, Department of Pharmacology, Saveetha Dental College, SIMATS, Saveetha University, Chennai, Tamilnadu, IN
3 Professor, Department of Pedodontics & Preventive Dentistry, Saveetha Dental College, SIMATS, Saveetha University, Chennai, Tamilnadu, IN
4 Associate Professor,Department of Microbiology, Saveetha Dental College, SIMATS, Saveetha University Chennai, Tamilnadu, IN
Source
Indian Journal of Public Health Research & Development, Vol 10, No 11 (2019), Pagination: 3540-3544Abstract
Aim: To evaluate Anti-Microbial Activity of taxifolin isolated from Acacia catechu leaf extract against Streptococcus mutans and Lactobacillus acidophilus.
Objectives: The study is to determine the antimicrobial activity of taxifolin isolated Acacia catechu leaf extract against Streptococcus mutans and Lactobacillus acidophilus.
Background: An anti microbial is a agent that kills or inhibits the growth of micro organism such as bacteria and fungi. Acacia catechu also commonly called Mimosa catechu, is a deciduous, thorny tree which grows up to 15 m (50 ft) in height. Acacia catechu traditionally used for curing many diseases and commonly for mother and child healthcare. Taxifolin is the main constituent of Acacia catechu which possesses antifungal, antiviral, antibacterial, anti-inflammatory and anti-oxidant activity.
Reason: This study is to evaluate the anti microbial activity of Acacia catechu against micro organisms such as Streptococcus mutans and Lactobacillus acidophilus. This may help in development of health products without artificial chemical agent.