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Santoso, Budi
- Contributing Factors of Neonatal Death Frommother with Preeclampsia in Indonesia
Authors
1 Universitas Airlangga, ID
Source
Indian Journal of Public Health Research & Development, Vol 10, No 11 (2019), Pagination: 1992-1996Abstract
Background: Preeclampsia is one of the main causes of maternal and neonatal morbidity and mortality in developing countries. The infant mortality rate in Indonesia has decreased but is still quite high. The purpose of this study was to analyze the factors that contribute to the death of infants from mothers with preeclampsia.
Method: This research is a design retrospective cross-sectional study conducted in women with a history of preeclampsia are recorded in the data Dr. Soetomo hospital over a period of one year. Total respondents were 32 4. Demographic data on preeclamptic mothers (gestational age, age, parity and mode of delivery) and infant mortality data were collected which were then analyzed descriptively and chi-square test.
Results: The results showed a significant relationship between maternal age with preeclampsia (p = 0.005), age of maternal pregnancy with preeclampsia (p = 0.000) and mode of delivery of mothers with preeclampsia (p = 0.000) with the incidence of death in infants, and none a significant relationship between maternal parity status with preeclampsia (p = 0.043) with the incidence of death in infants.
Conclusion: factors that contribute to infant mortality from mothers with preeclampsia are age, gestational age, and mode of delivery.
Keywords
Contributing Factors, Preeclampsia, Neonatal Death.- Gene Analysis Polymorphisms INSR and Level SHBG, as Risk Factors in Polycystic Ovary Syndrome (PCOS) in Madurese
Authors
1 Doctoral Medical Sciences, Brawijaya University, ID
2 Brawijaya University, ID
3 Department of Medical Biochemistry, Brawijaya University, ID
4 Department of Anatomy and Histology, Brawijaya University, ID
5 Department of Veterinary Medicine, Brawijaya University, ID
Source
Indian Journal of Public Health Research & Development, Vol 10, No 11 (2019), Pagination: 2124-2127Abstract
PCOS (Polycystic ovary syndrome) one of the endocrine disorders most often in women of reproductive age, marked menstrual disorders (amenorrhea/oligomenorrhea), hirsutism, acne, alopecia, biochemical examination results in increased androgen. The high incidence with the same phenotype in family members of PCOS patients shows that genetic factors play a role. The purpose of this study was to analyze the relationship between gene polymorphism INSR and levels SHBG on PCOS (Polycystic ovary syndrome) in the Madurese tribe.
This study was analytic observational with study design case-control, a sample of 30 patients (PCOS cases) and 30 healthy women (not PCOS) in the Madura Tribe Previously, screening of SGOT, SGPT, BUN, Creatinin and GDA, PCR and RFLP was examined in the INSR gene and examination of SHBG levels by ELISA kit.gene research results INSR have 16.67% TT genotype, 63.33% TC and 20.00% CC, control group has 38.24% TT genotype, TC 44.12% and CC 17.65%, whereas in the case group T 48.33%, C allele 51.67% and control group 56.67% T allele and 43.33% C allele, based onstatistical tests chi-square in the case group and control of both genotypes and alleles there was no significant difference (P> 0.05). This study was first carried out in the Madura Tribe in the INSR gene and in the examination of SHBG levels, the results showed no INSR gene differences between PCOS and healthy women.