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Gupta, Ankush
- Correlation of Apoptotic Index and Bcl-2 Protein with other Histological Prognostic Factors in Prostate Carcinoma
Abstract Views :189 |
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Authors
Affiliations
1 LLRM Medical College Meerut, IN
2 Department of Pathology, L.L.R.M Medical College Meerut, IN
3 Department of Surgery, S. N. Medical College, Agra, IN
1 LLRM Medical College Meerut, IN
2 Department of Pathology, L.L.R.M Medical College Meerut, IN
3 Department of Surgery, S. N. Medical College, Agra, IN
Source
Indian Journal of Public Health Research & Development, Vol 3, No 2 (2012), Pagination: 123-126Abstract
This study was conducted to evaluate the correlation of Apoptotic Index and Bcl-2 protein expression immuno-histochemically in Prostate Cancers with known histological prognostic factors in prostate Carcinoma including Gleason's score and Angiogenic index (AgCD-31). The study group consisted of 35 cases of prostate adenocarcinoma obtained from the patients admitted in Dept. of Surgery and from cancer registry of Department of SN medical collage Agra. The specimens were subjected to hematoxylin and eosin staining, bcl-2 immuno histochemical staining, Apoptotic index calculation, Gleason's grading. Univariate analysis showed no correlation between apoptotic index (A.I.)&Gleason's grade {mean A.I. 2.23±1.72 (intermediate grade) and 1±0.85 (high grade); p>0.05}, negative correlation between apoptotic index and angiogenic index {mean angiogenic index =109.82 (intermediate grade)&247.35 (high grade); p0.05). Besides grading, quantification of Bcl-2 antiapoptotic protein and angiogenic index can be of value to predict prognosis of prostate carcinoma. Bcl-2 immunostain can be used on TURP specimens where often grading may not be representative of the entire specimen.Keywords
Apoptotic Index, bcl-2, Angiogenic Index, Prostate Cancer
References
- Kumar V, Cotran SR, and Robbins SL: Robbin’s Basic Pathology, 7th edn. Philadelphia, Elsevier, 2003, pp 667-669.
- Babaian RJ, Mettlin C, Kane R et al.: The relationship of prostate-specific antigen to digital rectal examination and transrectal ultrasonography. Findings of the American Cancer Society National Prostate Cancer Detection Project. Cancer 1992; 69(5):1195-2000,
- Cupp MR and Oesterlin JE: Prostate-specific antigen, digital rectal examination, and transrectal ultrasonography: their roles in diagnosing early prostate cancer. Mayo Clin Proc 1993; 68(3):297-306
- szegezdi E,Macdonald DC, Nichonghaile T et.al.:Bcl-2 family on guard at the ER. American J physiolcell physiol 2009; 296(5):c941-53
- Heath-Engel HM, ChangNC, ShoreGC: The endoplasmic reticulum in apoptosis and autophagy : role of the Bcl-2 protein family. Oncogene 2008; 27(50):6419-33
- Soini Y, Virkajarvi N, Lehto VP et al.: Hepatocellular carcinomas with a high proliferation index and a low degree of apoptosis and necrosis are associated with a shortened survival. Br. J Cancer 1996; 73: 1025-1030
- Krajewska M, Krajewski S et al.: Immuno histochemical analysis of bcl-2 bax, bcl and mcl-1 expression in prostate cancers. Am J Pathol 1996; 148: 1567-76
- Tanji N and Yokoyama M: Apoptosis in prostate adenocarcinoma; a study of relationship to ki-67 and bcl-2 protein expression. Anticancer Res 1998; 18(28): 1111-6
- McDonnel TJ, Troncoso P, Brisbay SM et al.: Expression of proto-oncogene bcl-2 in the prostate and its association with emergence of androgen independent prostate cancer. Cancer Res 1992; 52: 6940-6944
- Hering O, Lipay M, Srougi M et al.: Comparison of positivity frequency of bcl-2 expression in prostate adenocarcinoma with low and high Gleason Score. Sao Paulo Med J 2001; 119(4):138-41
- T. Suji M, Y. Murakami, H. Kanayama et al.: Immuno histochemical analysis of ki – 67 antigen and bcl-2 protein expression in prostate cancer: effect of neoadjuvant hormonal therapy. Br J of Urol 1998; 81: 116-121
- Khor LY, Moughan J,AL-saleem t, et.al: Bcl-2 and Bax expression predict prostate cancer outcome in man treated with androgen deprivation and radiotherapy on radiation therapy oncology group protocol 92-02. Clinical cancer research 2007; 13(12): 3585-90
- Lipponen P and Vesalainen S: Expression of the apoptosis suppressing protein bcl-2 in prostatic adenocarcinoma in related to tumor malignancy. The Prostate 1997; 32: 9-15
- Tanji N and Yokoyama M: Apoptosis in prostate adenocarcinoma; a study of relationship to ki-67 and bcl-2 protein expression. Anticancer Res 1998; 18 (28): 1111-6
- Amirghofran Z, Monabati A and Gholijani N: Apoptosis in prostate cancer: Bax correlation with stage. Int J Urol 2005; 12 (4): 340-345
- Brown C and Sauvageot J: Cell proliferation and apoptosis in prostate cancer- correlation with pathologic stage? Mod Pathol 1996; 9(3): 205-9
- Matsuhima H, Goto T, Kawabe K et al.: Correlation between proliferation, apoptosis and angiogenesis in prostate carcinoma and their relation to androgen ablation. Cancer 1999; 85(8):1822-27
- Tu H and Jacobs SC: Incidence of apoptosis and cell proliferation in prostate cancer relationship with TGF- beta 1 and bcl-2 expression. Int J Cancer1996; 69(5): 357-63
- Bettencourt MC, Bauer JJ, Sesterhenn IA et al.: CD34 immuno histochemical assessment of angiogenesis as a prognostic marker for prostate cancer recurrence after radical prostatectomy. J Urol 1998; 160(2):459-65
- Correlation of Apoptotic Index and Bcl-2 Protein with other Histological Prognostic Factors in Prostate Carcinoma
Abstract Views :214 |
PDF Views:0
Authors
Affiliations
1 Department of Pathology, LLRM Medical College, Meerut U.P., IN
2 Department of Pathology, LLRM Medical College Meerut, Uttar Pradesh, IN
3 Department of Surgery, S. N. Medical College, Agra, Uttar Pradesh, IN
1 Department of Pathology, LLRM Medical College, Meerut U.P., IN
2 Department of Pathology, LLRM Medical College Meerut, Uttar Pradesh, IN
3 Department of Surgery, S. N. Medical College, Agra, Uttar Pradesh, IN
Source
Indian Journal of Public Health Research & Development, Vol 3, No 3 (2012), Pagination: 97-101Abstract
This study was conducted to evaluate the correlation of Apoptotic Index and Bcl-2 protein expression immunohistochemically in Prostate Cancers with known histological prognostic factors in prostate Carcinoma including Gleason's score and Angiogenic index (AgCD-31). The study group consisted of 35 cases of prostate adenocarcinoma obtained from the patients admitted in Dept. of Surgery and from cancer registry of Department of SN Medical Collage Agra. The specimens were subjected to hematoxylin and eosin staining, Bcl-2 immuno histochemical staining, Apoptotic index calculation, Gleason's grading. Univariate analysis showed no correlation between apoptotic index (A.I.)&Gleason's grade {mean A.I. 2.23±1.72 (intermediate grade) and 1±0.85 (high grade); p>0.05}, negative correlation between apoptotic index and angiogenic index {mean angiogenic index =109.82 (intermediate grade)&247.35 (high grade); p0.05). Besides grading, quantification of Bcl-2 antiapoptotic protein and angiogenic index can be of value to predict prognosis of prostate carcinoma. Bcl-2 immunostain can be used on TURP specimens where often grading may not be representative of the entire specimen.Keywords
Apoptotic Index, Bcl-2, Angiogenic Index, Prostate CancerReferences
- Kumar V, Cotran SR, and Robbins SL: Robbin’s Basic Pathology, 7th edn. Philadelphia, Elsevier, 2003, pp 667-669.
- Babaian RJ, Mettlin C, Kane R et al.: The relationship of prostate-specific antigen to digital rectal examination and transrectal ultrasonography. Findings of the American Cancer Society National Prostate Cancer Detection Project. Cancer 1992; 69(5):1195-2000,
- Cupp MR and Oesterlin JE: Prostate-specific antigen, digital rectal examination, and transrectal ultrasonography: their roles in diagnosing early prostate cancer. Mayo Clin Proc 1993; 68(3):297-306,
- szegezdi E,Macdonald DC, Nichonghaile T et.al.:Bcl-2 family on guard at the ER. American J physiolcell physiol 2009; 296(5):c941-53.
- Heath-Engel HM , ChangNC, ShoreGC: The endoplasmic reticulum in apoptosis and autophagy : role of the Bcl-2 protein family. Oncogene 2008; 27(50):6419-33.
- Soini Y, Virkajarvi N, Lehto VP et al.: Hepatocellular carcinomas with a high proliferation index and a low degree of apoptosis and necrosis are associated with a shortened survival. Br. J Cancer 1996; 73: 1025-1030,
- Krajewska M, Krajewski S et al.: Immuno histochemical analysis of bcl-2 bax, bcl and mcl- 1 expression in prostate cancers. Am J Pathol 1996; 148: 1567-76,
- Tanji N and Yokoyama M: Apoptosis in prostate adenocarcinoma; a study of relationship to ki-67 and bcl-2 protein expression. Anticancer Res 1998; 18(28): 1111-6,
- McDonnel TJ, Troncoso P, Brisbay SM et al.: Expression of proto-oncogene bcl-2 in the prostate and its association with emergence of androgen independent prostate cancer. Cancer Res 1992; 52: 6940-6944,
- Hering O, Lipay M, Srougi M et al.: Comparison of positivity frequency of bcl-2 expression in prostate adenocarcinoma with low and high Gleason Score. Sao Paulo Med J 2001; 119(4):138- 41,
- T. Suji M, Y. Murakami, H. Kanayama et al.: Immuno histochemical analysis of ki – 67 antigen and bcl-2 protein expression in prostate cancer: effect of neoadjuvant hormonal therapy. Br J of Urol 1998; 81: 116-121,
- Khor LY, Moughan J,AL-saleem t, et.al: Bcl-2 and Bax expression predict prostate cancer outcome in man treated with androgen deprivation and radiotherapy on radiation therapy oncology group protocol 92-02. Clinical cancer research 2007; 13(12): 3585-90.
- Lipponen P and Vesalainen S: Expression of the apoptosis suppressing protein bcl-2 in prostatic adenocarcinoma in related to tumor malignancy. The Prostate 1997; 32: 9-15,
- Tanji N and Yokoyama M: Apoptosis in prostate adenocarcinoma; a study of relationship to ki-67 and bcl-2 protein expression. Anticancer Res 1998; 18 (28): 1111-6,
- Amirghofran Z, Monabati A and Gholijani N: Apoptosis in prostate cancer: Bax correlation with stage. Int J Urol 2005; 12 (4): 340-345,
- Brown C and Sauvageot J: Cell proliferation and apoptosis in prostate cancer- correlation with pathologic stage? Mod Pathol 1996; 9(3): 205-9,
- Matsuhima H, Goto T, Kawabe K et al.: Correlation between proliferation, apoptosis and angiogenesis in prostate carcinoma and their relation to androgen ablation. Cancer 1999; 85(8):1822-27,
- Tu H and Jacobs SC: Incidence of apoptosis and cell proliferation in prostate cancer relationship with TGF- beta 1 and bcl-2 expression. Int J Cancer1996; 69(5): 357-63,
- Bettencourt MC, Bauer JJ, Sesterhenn IA et al.: CD34 immuno histochemical assessment of angiogenesis as a prognostic marker for prostate cancer recurrence after radical prostatectomy. J Urol 1998; 160(2):459-65.