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Sreekantha,
- A Study of Dexmedetomidine Compared with Midazolam for Sedation in Endoscopic Dacryocystorhinostomy
Authors
1 Department of Anaesthesiology, Navodaya Medical College, Raichur, Karnataka, IN
2 Department of ENT, Navodaya Medical College, Raichur, Karnataka, IN
3 Department of Biochemistry, Navodaya Medical College Hospital, Raichur-584 102, Karnataka, IN
4 Department of ENT, AJIMS, Mangalore, Karnataka, IN
5 Department of Pharmacology, KMC, Manipal University, Karnataka, IN
6 Department of Biochemistry, FMMC, Mangalore, Karnataka, IN
Source
Indian Journal of Public Health Research & Development, Vol 4, No 1 (2013), Pagination: 185-189Abstract
Purpose: The objective of this study were to study the efficacy of dexmedetomidine as a sedative for endoscopic dacryocystorhinostomy performed under local anaesthesia compared to conventional sedative like midazolam and also to study the effects of dexmedetomidine on hemodynamic stability and analgesia.
Methods: In this randomized,prospective double-blinded study 40 adult patients were allocated into two groups.Group D received dexmedetomidine 1μg/kg loading dose over 10 minutes followed by 0.5 μg/kg/hr maintenance dose and Group M received 20 μg/kg midazolam at the start of procedure plus same dose repeated 30 minutes later. Endoscopic dacryocystorhinostomy was performed in all patients under local anesthesia. Sedation was assessed using the modified Observer's Assessment Alertness/ Sedation (OAA/S) scale. Pulse rate(PR), Mean arterial pressure(MAP),oxygen saturation (SpO 2), respiratory rate (RR) were recorded every 5 minutes for first fifteen minute and then every ten minutes till the end of the procedure.In the post anaesthesia care unit,Aldrete score was determined every 5 minutes till the patient was ready for discharge.
Results: Pateints receiving dexmedetomidine had a better OAA/S score throughout the procedure and were more cooperative. VAS scores were significantly lower in the dexmedetomidine group.Pulse rate, MAP were lower in Group D whereas SpO 2 values were higher in Group D compared to Group M. Group D had lesser amount of bleeding but the time taken to reach an Aldrete score of 10 was similar between the groups.
Conclusion: Dexmedetomidine is ideal for procedural sedation with the added benefit of hemodynamic stability, no respiratory depression and analgesia.
Keywords
Dexmedetomidine, Sedation, Midazolam, Endoscopic Dacryocystorhinostomy
References
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- The Study of Arthroscopic Reduction of Tibial Spine Avulsion Fractures in Adults
Authors
1 Department of Orthopedics, NMC, Raichur, IN
2 Department of Anaesthesia, RIMS, Raichur, IN
3 Fortis, Hospital, Nagarbhavi, Bangalore, IN
4 Hosmat Hospital, Bangalore, IN
5 Department of Biochemistry, Navodaya Medical College, Raichur-584103, Karnataka, IN
6 Department of Anatomy, Nitte University, KSHEMA, Mangalore, IN
Source
Indian Journal of Public Health Research & Development, Vol 4, No 3 (2013), Pagination: 272-274Abstract
Tibial spine fracture is relatively rare variety of fracture in the orthopedic practice. They present with unusual etiology, mode of presentation and complications. The methodology of treatment of these fractures may be conservative, surgery or arthroscopic reduction. Patients who were diagnosed with tibial spine avulsion were analyzed; 22 patients diagnosed clinically were evaluated in detail for etiology, presentation and treatment setup. The knowledge of early detection of tibial spine fracture and accuracy treatment yields best outcome.Keywords
Tibial Spine Fracture, Presentation, TreatmentReferences
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- The Study of Sensorineural Hearing Loss in Pseudoexfoliation Syndrome
Authors
1 Department of Ophthalmoloy, Department of Biochemistry, Navodaya Medical College, Hospital and Research Centre, Raichur, Karnataka, IN
2 Department of Otorhinolaryngology, Department of Biochemistry, Navodaya Medical College, Hospital and Research Centre, Raichur, Karnataka, IN
3 Department of Orthopaedics, Department of Biochemistry, Navodaya Medical College, Hospital and Research Centre, Raichur, Karnataka, IN
4 Department of Biochemistry, Navodaya Medical College, Raichur-584103, Karnataka, IN
Source
Indian Journal of Public Health Research & Development, Vol 4, No 3 (2013), Pagination: 287-290Abstract
Purpose: Determine hearing thresholds at sound frequencies important for speech comprehension in subject with ocular pseudoexfoliation (PXF) and to compare them with that of control without PXF.
Method: 60 subjects with ocular PXF and 60 age and sex matched controls without PXF were enrolled in this case-control study. Pure tone audiometry (bone conduction) was performed at 1,2 and 3 kilohertz (KHz) in all subjects. Thresholds were compared to an age and sex stratified standard (ISO7029) and between study groups. Hearing loss was defined as sum of tested hearing thresholds (HTL-1,2,3) lower than the ISO7029 standard median.
Results: The study included 35 males and 25 females subject in each group. Hearing loss was present in 97 of 120 (80.83%) of examined ears in the case group Vs 52 of 120 (43.3%) in the control group [P<0.001; odds ratio(OR) = 5.51; 95% confidence interval (CI) ]. overall 54 subjects ( 90%) in the case group Vs 37 subjects 61.6 % in the control group had hearing loss in one or both ears (P<0.001; odds ratio(OR) = 5.5; 95% confidence interval. Hearing thresholds at each of the examined frequencies and the HTL- 1,2,3 were also significantly higher in individuals with PXF.
Conclusions: Hearing thresholds at frequencies which are important for speech comprehension are significantly worse in individuals with ocular PXF as compared to matched controls. This finding may support the multi-organ nature of PXF syndrome.
Keywords
PXF Syndrome, Hearing LossReferences
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- Gamma Glutamyl Transpeptidase and Total Cholesterol Levels in Smokers and Congestive Cardiac Failure Patients
Authors
1 Department of Biochemistry, Navodaya Medical College, Raichur, Karnataka, IN
2 Department of Biochemistry, KMC, Manipal University, Mangalore, Karnataka, IN
3 Department of Biochemistry, VIMS, Bellary, Karnataka, IN
4 Department of Biochemistry, FMMC, Kankanadi, Mangalore, Karnataka, IN
5 Department of Anatomy, KSHEMA, Nitte University, Mangalore, Karnataka, IN
Source
Indian Journal of Public Health Research & Development, Vol 3, No 2 (2012), Pagination: 165-167Abstract
Background and Objectives
The level of gamma glutamye transpeptidase (GGTP or GGT) is especifically increased in alcoholic liver diseases with biliary obstruction. There are many other diseases where alterations in the level of GGTP are noted. Hence, the study was aimed to estimate the level of GGTP in smokers and congestive cardiac failure (CCF) patients along with total cholesterol (TC).
Material and Methods
35 each clinically diagnosed CCF patients, smokers and normal healthy male subjects were included in the study. GGTP was estimated by enzymatic colorimetric method and total cholesterol by cholesterol oxidase peroxidase method using P-800 chemistry antoanalyser. Statistical analysis was done using ANOVA.
Results
The GGTP and TC levels were significantly (p<0.001) increased in the both CCF patients and smokers but increase is more significant in CCF patients.
Conclusion
GGTP can be used as a potential biomarker along with total cholesterol in cardiovascular diseases especially CCF because of their direct relationship with the indication of atherogenesis.
Keywords
GGTP, TC, CCF, SmokersReferences
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