Indian Journal of Oncology and Radiation Biology

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Antioxidant Activity of Geraniol on n-Nitrosodiethylamine-induced Hepatocarcinogenesis in Wistar Albino Rats


Affiliations
1 Department of Biochemistry, JBAS College for Women, Chennai, India
2 Prof. Dhanapalan College of Arts and Science, Chennai, India
3 PNG University of Technology, India
4 CLRI, Chennai, India
 

The chemopreventive effect of Geraniol was evaluated in N-nitrosodiethylamine-induced experimental liver tumor in Wistar albino rats. In this study the animals were divided into four groups with 6 rats each and received treatments for 4 weeks. Group I served as control (untreated), Group II treated with N-nitrosodiethylamine (DEN) (200 mgkg, i.p.) and Phenobarbital (PB) (0.05%) in drinking water; Group III received Geraniol (250 mg/kg b.wt) in addition to DEN and Group IV treated with Geraniol only for four weeks. The administration of Geraniol in rats with DEN induced HCC rats (Group III) shows a significantly reduced level of liver serum marker (aspartate aminotransferase, alanine aminotransferase, acid phosphatase, alkaline phosphatase, lactate dehydrogenase, gammaglutamyl transpeptidase, alpha fetoprotein and 5'nucleotidase). These results are evident that Geraniol possesses protective effect against N-Nitrosodiethylamine (DEN)-induced Hepatocellular Carcinogenesis (HCC).

Keywords

DEN, Carcinogenesis, HCC, Geraniol, Marker Enzymes
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  • Antioxidant Activity of Geraniol on n-Nitrosodiethylamine-induced Hepatocarcinogenesis in Wistar Albino Rats

Abstract Views: 439  |  PDF Views: 288

Authors

Fouzia Banu
Department of Biochemistry, JBAS College for Women, Chennai, India
Nausheen Dawood
Department of Biochemistry, JBAS College for Women, Chennai, India
Yamini Sudha Lakshmi
Prof. Dhanapalan College of Arts and Science, Chennai, India
S. Gopalakrishnan
PNG University of Technology, India
V. Brinda
CLRI, Chennai, India

Abstract


The chemopreventive effect of Geraniol was evaluated in N-nitrosodiethylamine-induced experimental liver tumor in Wistar albino rats. In this study the animals were divided into four groups with 6 rats each and received treatments for 4 weeks. Group I served as control (untreated), Group II treated with N-nitrosodiethylamine (DEN) (200 mgkg, i.p.) and Phenobarbital (PB) (0.05%) in drinking water; Group III received Geraniol (250 mg/kg b.wt) in addition to DEN and Group IV treated with Geraniol only for four weeks. The administration of Geraniol in rats with DEN induced HCC rats (Group III) shows a significantly reduced level of liver serum marker (aspartate aminotransferase, alanine aminotransferase, acid phosphatase, alkaline phosphatase, lactate dehydrogenase, gammaglutamyl transpeptidase, alpha fetoprotein and 5'nucleotidase). These results are evident that Geraniol possesses protective effect against N-Nitrosodiethylamine (DEN)-induced Hepatocellular Carcinogenesis (HCC).

Keywords


DEN, Carcinogenesis, HCC, Geraniol, Marker Enzymes