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Juneius, C. E. Rani
- Drug likeliness of 3,6-diisopropyl-2,5-piperazinedione - produced by Marine Sponge Associated Bacteria Rhodopseudomonas palustris MSB 55
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Authors
Affiliations
1 Department of Biotechnology, Hindustan College of Arts and Science, Padur,Chennai - 603103, IN
2 Department of Bioinformatics, Bharathidasan University, Trichi, IN
1 Department of Biotechnology, Hindustan College of Arts and Science, Padur,Chennai - 603103, IN
2 Department of Bioinformatics, Bharathidasan University, Trichi, IN
Source
Indian Journal of Medicine and Healthcare, Vol 1, No 1 (2012), Pagination: 1-11Abstract
Drug discovery and development is an intense, lengthy and an interdisciplinary endeavour. Drug discovery is mostly portrayed as a linear, consecutive process that starts with target and lead discovery, followed by lead optimization and pre-clinical in vitro and in vivo studies to determine if such compounds satisfy a number of pre-set criteria for initiating clinical development. In this present study a sponge Axinella donani was collected from Kanyakumari coast line and their associated bacteria were isolated and identified. Various therapeutic compounds were identified by the techniques such as spectroscopic and chromatographic methods. Drug likeliness of 3,6-diisopropyl-2,5-piperazinedione - produced by Rhodopseudomonas palustris MSB 55 was studied by Autodock from this study, it was found to be a Neuronal Nicotinic receptor served as target for 3,6-diisopropyl-2,5-piperazinedione. ADME/TOX tool helped to find out whether the molecule is obeying Lipinski's Rule of Five to evaluate drug likeness. From the present study it could be concluded that the sponge associated bacteria can serve as a source for therapeutic compounds.Keywords
Axinella donani, Rhodopseudomonas palustris, MSB 55, 3,6-diisopropyl-2,5-piperazinedione, Neuronal Nicotinic Receptor, Autodock, ADME/TOXFull Text
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