Indian Journal of Medicine and Healthcare

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Effects of Levonorgestrel, Ethinylestradiol and Norethisterone on Plasma Cholesterol and Triglycerides of Wistar Albino Rat (Rattus rattus)


Affiliations
1 Department of Biochemistry, University of Port Harcourt, P.M.B 5323, Port Harcourt Nigeria, Nigeria
 

The effects of Microgynon, a combined oral contraceptive pill (0.15mg levonorgestrel and 0.03mg ethinylestradiol) and Primolut -N, a progestogen only pill (5mg norethisterone) were analysed for their in-vivo effects on rat (<I>rattus rattus</I>) plasma cholesterol and triglycerides. The drugs decreased plasma cholesterol levels in a concentration dependent manner. Microgynon had the most effect, and a highest percentage decrease of 93.33% (0.002 &#177; 0.001 mmol/l (P &#x003C; 0.05)) was observed for the highest dose of 3.6&#956;g/100g body wt. Primolut had lesser effects with figures (0.008 &#177; 0.001 mmo/l and 0.009 &#177; 0.001mmol/l respectively). The drugs increased the levels of triglyceride with Microgynon showing the highest value (0.114 &#177; 0.006 mmol/l). This result indicates that lipoprotein profile are needed for women before using these drugs.

Keywords

Levonorgestrel, Ethinylestradiol, Norethisterone , Cholesterol, Triglycerides
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  • Effects of Levonorgestrel, Ethinylestradiol and Norethisterone on Plasma Cholesterol and Triglycerides of Wistar Albino Rat (Rattus rattus)

Abstract Views: 345  |  PDF Views: 280

Authors

A. A. Uwakwe
Department of Biochemistry, University of Port Harcourt, P.M.B 5323, Port Harcourt Nigeria, Nigeria
N. F. Okoye
Department of Biochemistry, University of Port Harcourt, P.M.B 5323, Port Harcourt Nigeria, Nigeria
O. E. Okafor
Department of Biochemistry, University of Port Harcourt, P.M.B 5323, Port Harcourt Nigeria, Nigeria

Abstract


The effects of Microgynon, a combined oral contraceptive pill (0.15mg levonorgestrel and 0.03mg ethinylestradiol) and Primolut -N, a progestogen only pill (5mg norethisterone) were analysed for their in-vivo effects on rat (<I>rattus rattus</I>) plasma cholesterol and triglycerides. The drugs decreased plasma cholesterol levels in a concentration dependent manner. Microgynon had the most effect, and a highest percentage decrease of 93.33% (0.002 &#177; 0.001 mmol/l (P &#x003C; 0.05)) was observed for the highest dose of 3.6&#956;g/100g body wt. Primolut had lesser effects with figures (0.008 &#177; 0.001 mmo/l and 0.009 &#177; 0.001mmol/l respectively). The drugs increased the levels of triglyceride with Microgynon showing the highest value (0.114 &#177; 0.006 mmol/l). This result indicates that lipoprotein profile are needed for women before using these drugs.

Keywords


Levonorgestrel, Ethinylestradiol, Norethisterone , Cholesterol, Triglycerides

References