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Kumar, M. Vijaya
- Formulation and evaluation of mucoadhesive buccal films of Diclofenac Sodium
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Authors
Affiliations
1 Shield Health Care Pvt Ltd, Chennai-600095, IN
1 Shield Health Care Pvt Ltd, Chennai-600095, IN
Source
Indian Journal of Innovations and Developments, Vol 1, No 2 (2012), Pagination: 68-73Abstract
Buccal drug delivery offers a safe and easy method of drug utilization, because drug absorption can be promptly terminated in case of toxicity by removing the dosage form from the buccal cavity. A buccal film for systemic administration of diclofenac sodium has been developed using hydroxyl propyl methylcellulose, poly vinyl pyrolidone, glycerin, eudragit and ethanol by solvent casting method. The prepared films characterized by means of film thickness, swelling capacity, in- vitro adhesion, drug release, weight variation, folding endurance, etc. The in vitro release studies were conducted for diclofenac sodium patches in phosphate buffer-pH-6.6 solution. The mechanism of release is diffusion process followed by first order kinetics. The formulated patches exhibit drug release in the range of 76.92 to 92.12% in four hours.Keywords
Mucoadhesive Film, Diclofenac Sodium, First Order Kinetics, in- vitro ReleaseFull Text
References
- Agarwal SP, Alka Ahuja and Khanna R (1998) Mucoadhesive buccal drug delivery; A potential alternative to conventional therapy. J.Controlled Release, 1-11.
- Alka Ahuja, Javed ali and Khar RK (1998) Buccoadhesive films of Triamicinolone Acetonide. Development and Evaluation of a Buccoadhesive-erodible carrier for treatment of oral lesions. J.Controlled Release, 60(5), 322-325.
- Alka Ahuja, Khar RK and Javed Ali (1997) Mucoadhesive drug delivery system, Drug Development and Industrial Pharmacy. J.Controlled Release, 489-515.
- Goodman and Gillman (2001) The Pharmacological Basis of Therapeutics, 5-6.
- Ilango R, Jeyakar B, Kavimani S and Mullaicharam AR (1997) In-vivo studies on buccal strips of Glibenclamide using Chitosan. J.Controlled Release, 59, 232-235.
- Khanna R., Agarwal SP and Ahuja alka (1998) Mucoadhesive buccal drug delivery: A potential alternative to conventional therapy. J.Controlled Release, 60(1), 1-11.
- Pai M, Pandey S, Singh UV and Udupa (1998) Mucoadhesive Formulation of Theophylline, J.Controlled Release, 60(4), 241-243.
- Remington (2005) The science and practice of pharmacy, 1157.
- Saisivam S (2000) Design and Evaluation of Diltiazem Hydrochloride Buccal Patches. J.Controlled Release, 62, 236-238.
- The Merck Index and Encyclopedia of Chemical (2001)
- Tripathi KD (2011) Essentials of Medical Pharmacology, 193.