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Balasubramanian, J.
- Formulation and in-vitro Drug Release for β-cyclodextrin Nanosphears using Emulsification Solvent-evaporation Method
Abstract Views :377 |
PDF Views:82
Authors
J. Balasubramanian
1,
N. Narayanan
1,
N. Shahul Hammed
1,
K. Maraicar
1,
N. Vijaya Kumar
1,
K. Azhagesh Raj
1
Affiliations
1 Shield Health Care Pvt Ltd, Chennai-600095, IN
1 Shield Health Care Pvt Ltd, Chennai-600095, IN
Source
Indian Journal of Innovations and Developments, Vol 1, No 2 (2012), Pagination: 64-67Abstract
This study gives information about the formulation of β-cylcodextrin nanosphere by emulsification solvent-evaporation method based on emulsifying an organic phase containing the β-cylcodextrin in an aqueous phase of pluronic-F68 as surfactant. The nanospheres are loaded with hydrophobic drug and the in-vitro drug release study was conducted. The formulation of colloidal particle was associated with amphiphilic properties of the β-cylcodextrin derivatives. However, the partitioning of the β- cyclodextrin between the organic and aqueous phases is always depends on the concentration of the surfactant. In the case of nanospheres loaded with Irinotican hydrochloride, the partitioning of the drug occurs between the dispersed phase containing β- cylcodextrin and the continuous aqueous phase containing pluronic-F68.Keywords
Amphiphilic Cyclodextrins, Emulsification, Solvent-evaporation Method, Nanospheres, Irinotecan, Surfactant, Pluronic-F68Full Text
References
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- Formulation and evaluation of mucoadhesive buccal films of Diclofenac Sodium
Abstract Views :456 |
PDF Views:72
Authors
Affiliations
1 Shield Health Care Pvt Ltd, Chennai-600095, IN
1 Shield Health Care Pvt Ltd, Chennai-600095, IN
Source
Indian Journal of Innovations and Developments, Vol 1, No 2 (2012), Pagination: 68-73Abstract
Buccal drug delivery offers a safe and easy method of drug utilization, because drug absorption can be promptly terminated in case of toxicity by removing the dosage form from the buccal cavity. A buccal film for systemic administration of diclofenac sodium has been developed using hydroxyl propyl methylcellulose, poly vinyl pyrolidone, glycerin, eudragit and ethanol by solvent casting method. The prepared films characterized by means of film thickness, swelling capacity, in- vitro adhesion, drug release, weight variation, folding endurance, etc. The in vitro release studies were conducted for diclofenac sodium patches in phosphate buffer-pH-6.6 solution. The mechanism of release is diffusion process followed by first order kinetics. The formulated patches exhibit drug release in the range of 76.92 to 92.12% in four hours.Keywords
Mucoadhesive Film, Diclofenac Sodium, First Order Kinetics, in- vitro ReleaseFull Text
References
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- Alka Ahuja, Khar RK and Javed Ali (1997) Mucoadhesive drug delivery system, Drug Development and Industrial Pharmacy. J.Controlled Release, 489-515.
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- A Preclinical Evaluation on Antioxidant and Gastroprotective Effect of Dioscorea Bulbifera in Wistar Rats
Abstract Views :561 |
PDF Views:67
Authors
Affiliations
1 Shield health care Pvt Ltd, Chennai-600095, Tamil Nadu, IN
2 SASTRA University, Tanjavur-613401, Tamil Nadu, IN
1 Shield health care Pvt Ltd, Chennai-600095, Tamil Nadu, IN
2 SASTRA University, Tanjavur-613401, Tamil Nadu, IN
Source
Indian Journal of Innovations and Developments, Vol 1, No 3 (2012), Pagination: 149-154Abstract
The present study was undertaken to evaluate the gastro-protective effect of hydro alcohol extract of Dioscorea bulbifera (DB) tubers Linn in indomethacin-induced gastric ulcers in rats at doses of 100, 200 and 400 mg/kg body weight. The gastric lesions were significantly reduced by all doses of DB as compared with the Indomethacin (100 mg/kg body weight) treated group. In the stomach tissues of treated animals, the in-vitro antioxidant levels were evaluated. The administration of indomethacin caused a significant decrease in the levels of peroxidase, catalase (CAT) and an increase in glutathione peroxidase (GPx) and reduced glutathione (GSH), and lipid peroxidation (LPO) level. The administration of all doses of DB reversed the trend, inducing a significant increase of peroxidase, Catalase and a reduction in GPx, GSH and LPO level in tissues. These results suggest that the gastro-protective effect of DB can be attributed to its reducing effect on the oxidative damage in rats.Keywords
Gastro-protective Activity, Dioscorea Bulbifera, Indomethacin, Antioxidant ActivityFull Text
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