Indian Journal of Forensic Medicine & Toxicology

Vivek Sharma ¹, M. C. Gupta ¹, Sushma Sood ², Shalini Sharma ²

Affiliations
1 Pharmacology, PGIMS, Rohtak
2 Physiology, PGIMS, Rohtak

Abstract

A hazardous chemical is defined by the U.S. Occupational Safety and Health Administration as "any chemical that has been shown scientifically to be a health hazard (causes acute or chronic health effects) or a physical hazard (combustible liquid, explosive, flammable, etc.)". This federal agency estimates that there are about 5.7 lakhs chemicals in the workplace, with 50,000 being potentially hazardous. Considering that unplanned exposures and contamination that can occur at any time during manufacturing, transport, storage, usage, or disposal of these chemicals, inevitably, emergency physicians will, at some time, be responsible for the management and care of a hazardous materials patient. When managing a patient exposed to an industrial chemical, it is helpful to refer to the material safety data sheet. Here, specific physical and hazardous properties of a particular substance are described, including the risk for absorption after inhalation or dermal exposure, and the potential for systemic toxicity . But although the material safety data sheet will also include "first aid" recommendations, it is strongly recommended to consult with a medical toxicologist or a regional poison control center to discuss optimal, case-specific hazards, treatments, and dispositions. Some agents may result in delayed onset of symptoms that require at least 12 to 24 hours of monitoring. Also, contacting the regional poison control center facilitates accurate data collection and analysis of toxicologic exposures in the community.

Keywords

Cholinergic Toxicity, Delayed Toxicity, Hydrocarbons, Pulmonary Edema, Respiratory Symptoms, Metabolic Toxicity

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Vivek Sharma ¹, M. C. Gupta ², Sushma Sood ³, Shalini Sharma ⁴

Affiliations
1 Pharmacology 29 /9 J, PGIMS, Rohtak-124001, IN
2 Pharmacology, IN
3 Physiology, IN
4 Physiology, PGIMS, Rohtak

Abstract

A hazardous chemical is defined by the U.S. Occupational Safety and Health Administration as "any chemical that has been shown scientifically to be a health hazard (causes acute or chronic health effects) or a physical hazard (combustible liquid, explosive, flammable, etc.)". This federal agency estimates that there are about 5.7 lakhs chemicals in the workplace, with 50,000 being potentially hazardous. Considering that unplanned exposures and contamination that can occur at any time during manufacturing, transport, storage, usage, or disposal of these chemicals, inevitably, emergency physicians will, at some time, be responsible for the management and care of a hazardous materials patient. When managing a patient exposed to an industrial chemical, it is helpful to refer to the material safety data sheet. Here, specific physical and hazardous properties of a particular substance are described, including the risk for absorption after inhalation or dermal exposure, and the potential for systemic toxicity . But although the material safety data sheet will also include "first aid" recommendations, it is strongly recommended to consult with a medical toxicologist or a regional poison control center to discuss optimal, case-specific hazards, treatments, and dispositions. Some agents may result in delayed onset of symptoms that require at least 12 to 24 hours of monitoring. Also, contacting the regional poison control center facilitates accurate data collection and analysis of toxicologic exposures in the community.

Keywords

Cholinergic Toxicity, Delayed Toxicity, Hydrocarbons, Pulmonary Edema, Respiratory Symptoms, Metabolic Toxicity

Full Text