Indian Journal of Forensic Medicine & Toxicology

Omid Mehrpour ¹, Mandana Dolati ², Kambiz Soltaninejad ³, Shahin Shadnia ⁴, Bashir Nazparvar ⁵

Affiliations
1 Department of Forensic Medicine, Faculty of Medicine, Medical Sciences/University of Tehran, IR
2 Department of Forensic Pathology, Scientific and Educational Research Center of Legal Medicine Organization of Iran, Tehran, IR
3 Department of Forensic Toxicology, Scientific and Educational Research Center of Legal Medicine Organization of Iran, Tehran, IR
4 Loghman Hakim Poison Center, Faculty of Medicine, Medical Sciences/University of Shaheed Beheshti, Tehran, IR
5 Autopsy Service, Scientific and Educational Research Center of Legal Medicine Organization of Iran, Tehran, IR

Abstract

This study examines histopathological changes of human organs in cases with aluminum phosphide fatal poisoning. The cases with aluminum phosphide fatal poisoning in Tehran Legal Medicine Center over 12 month period starting in March 2006, were studied. Necropsy was performed for all cases and liver, lung, brain, kidney and spleen were collected from all cases and fixed in formaldehyde solution (37% formalin).Tissue specimens were taken from organs and processed by routine histological method. Then any histhopathological changes were recorded by pathologist. In gross examination, almost all the vital organs were found to be congested. In microscopic study, the most frequent histopathological findings in liver were central venous congestion, degeneration of hepatocytes and mononuclear infiltration. In lung, alveolar thickening, and dilated capillaries were detected. Findings in the brain tissue revealed degenerated Nissel granule in the cytoplasm and deeply stained degenerated eccentric nucleus in brain cortex. Changes in the kidney included glomerulus's and intraparanchymal congestion. These findings indicated that histopathological changes are common in aluminum phosphide fatal poisoning.

Keywords

Aluminum Phosphide, Histopathology, Fatal Poisoning.

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