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Onyieke, E. N.
- Phytochemical Analysis of the Yoruba Medicinal Formulations- "Gbogbo Nise" and its Effect on Some Liver Enzymes
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PDF Views:1157
Authors
Affiliations
1 Department of Biochemistry, University of Port-Harcourt, Choba, Rivers state, NG
1 Department of Biochemistry, University of Port-Harcourt, Choba, Rivers state, NG
Source
Indian Journal of Drugs and Diseases, Vol 2, No 5 (2013), Pagination: 280-287Abstract
The Yoruba formulation called Gbogbo nise is one of the most widely consumed medicinal formulation in the rural areas of Nigeria. The aim of this study was to screen for the various phytochemicals in this medicinal formulation and the effects of these formulations on some liver enzymes of wistar albino rats. Sixty-four rats irrespective of sex were used in this study. They were divided into six groups (control and Groups A-E); with groups A-E split into three sub-groups for testing at week 2, 4 and 6. Each sub group contained four rats and was administered 2.9μl/Kg B.W of each medicinal formulation. Phytochemical screening indicated the presence of alkaloids, saponins, tannins, flavonoids and terpenoids. Biochemical examination of the serum of experimental groups after 2 weeks of administration, showed an initial reduction in activities of AST, ALT and ALP when compared with control groups. For the results at weeks 4 and 6, all five formulations resulted in significant increase in the level of these marker enzymes. Thus the prolong administration of these medicinal formulation at the dosage used in the study, results in rise in liver enzymes and may be indicative of hepatic damage.Keywords
Yoruba, Gbogbo Nise, Phytochemicals,liver EnzymesFull Text
References
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- Effect of Selected Yoruba Medicinal Formulations on Certain Biochemical Parameters in Wistar Albino Rats
Abstract Views :532 |
PDF Views:392
Authors
Affiliations
1 Department of Biochemistry, University of Port-Harcourt, Choba, Rivers state, NG
1 Department of Biochemistry, University of Port-Harcourt, Choba, Rivers state, NG
Source
Indian Journal of Drugs and Diseases, Vol 2, No 5 (2013), Pagination: 288-293Abstract
Yoruba medicinal formulations derived from plant extracts are fast becoming one of the most widely consumed medicinal formulation in the rural areas of Nigeria. The aim of this study was to screen evaluate the effect of this medicinal formulation on cetain biochemical parameters of wistar albino rats. Sixty-four rats irrespective of sex were used in this study. They were divided into six groups (control and Groups A-E); with groups A-E split into three groups for testing at week 2, 4 and 6. Each sub group contained four rats and was administered 2.9μl/Kg B.W of each medicinal formulation. Cage side examination was done daily to observe overt signs of toxicity (salivation, lacrimation, yellowing of fur etc). The formulation resulted in a significant increase then reduction in the body weight. Markers of hepatocyte injury; alanine transaminase and aspartate transaminase, were initially reduced but increased at week 4. Same was observed for the cholestasis marker alkaline phosphatase. The levels of serum creatinine, urea and blood urea nitrogen steadily reduced over time. The histological findings of the liver sections indicated gross cirrhosis, degeneration, inflammation and apoptosis in the experimented groups as compared to the control group.Keywords
Yoruba, Biochemical ParametersFull Text
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