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Arhoghro, E. M.
- Effects of Doses of Bryophylum pinnatum and Glibenclamide on Serum Glucose and Lipid Profile in Alloxan-induced Diabetic Rats
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PDF Views:426
Authors
Affiliations
1 Department of Biochemistry, University of Port Harcourt, Rivers State, NG
2 Department of Medical Biochemistry, Niger Delta University, Bayelsa State, NG
1 Department of Biochemistry, University of Port Harcourt, Rivers State, NG
2 Department of Medical Biochemistry, Niger Delta University, Bayelsa State, NG
Source
Indian Journal of Drugs and Diseases, Vol 1, No 5 (2012), Pagination: 124-128Abstract
This study was aimed at comparing the antidiabetic and antihyperlipidemic activities of various doses (100,150, 200mg/kg body weight) of crude ethanol extract of Bryophyllum pinnatum and Glibenclamide (a reference drug). Thirty adult male rats (Wistar strain) weighing between 170-200g were used in this study. After 14 days of treatment, the rats were sacrificed and blood collected from the jugular vein was analysed accordingly. Results obtained showed that there were no significant differences (PBryophyllum pinnatum and the reference drug in serum glucose, total cholesterol, triglycerides, and low density lipoprotein cholesterol (LDL) levels. All doses of the extract of Bryophyllum pinnatum and the reference drug increased the levels of high-density lipoprotein cholesterol (HDL) but the increase were not significant (PBryophyllum pinnatum. Extracts of Bryophyllum pinnatum may thus help in the management of diabetes mellitus and its related complications.Keywords
Diabetes Mellitus, Alloxan, Bryophyllum pinnatum, Lipid Profile and Atherogenic IndexReferences
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- Ocimum gratissimum Aqueous Extract Enhances Recovery in Cisplatin - Induced Nephrotoxicity in Albino Wistar Rats
Abstract Views :717 |
PDF Views:919
Authors
Affiliations
1 Department of Medical Biochemistry, Niger Delta University, Bayelsa State, NG
2 Department of Biochemistry, University of Port Harcourt, Rivers State, NG
1 Department of Medical Biochemistry, Niger Delta University, Bayelsa State, NG
2 Department of Biochemistry, University of Port Harcourt, Rivers State, NG
Source
Indian Journal of Drugs and Diseases, Vol 1, No 5 (2012), Pagination: 129-142Abstract
In the current study, the dose dependent(5% and 10%) and time course curative potential of aqueous leaf extract of Ocimum gratissimum (O.G.) on cisplatin induced nephrotoxic rats using biochemical and histopathological approaches was evaluated. Male albino wistar rats weighing between 150-200g were randomly separated into four different groups. Tissue damage was induced in rats of groups 2, 3 and 4 by a single intraperitoneal administration of cisplatin(5mg/kg b.w). Test rats in groups' 3 and 4 were treated 3 days after cisplatin injection intraperitoneally (i.p) with 5% and 10% C.C. accordingly for 3,6,9 and 12 days. Rats in group 2 were given sterile water in place of the extracts while rats in group I were the untreated controls. They were all allowed unlimited access to tap water and growers' mash. Cisplatin treatment caused increases (P≤ 0.05) in serum urea from 5.733 ± 0.06 to 13.000 ± 0.10 mmol/l, creatinine, uric acid, urine volume and urinary protein. Significant decreases (P≤ 0.05) in urinary creatinine were also observed. There were considerable decreases (P≤ 0.05) in body weight and increase (P≤ 0.05) in kidney weight to body weight ratio. However most of these changes were alleviated by prophylactic treatment with aqueous extract of Ocimum gratissimum dose and time dependently (P≤ 0.05).The ameliorating effect was further evident through decreased histopathological alterations of kidney tissues in the groups treated with aqueous extract of Ocimum gratissimum (5% and 10%). The results of this study indicate that aqueous leaf extracts of Ocimum gratissimum affect the course of tubular repair after the onset of cisplatin-induced nephrotoxicity in rats with accelerated recovery. Hence the extracts have the potential to be used for the management of nephropathies and as a therapeutic adjuvant in cisplatin toxicity.Keywords
Ocimum gratissimum, Nephrotoxicity, Cisplatin, NephropathiesReferences
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