Indian Journal of Drugs and Diseases

Open Access Open Access  Restricted Access Subscription Access

Effects of Doses of Bryophylum pinnatum and Glibenclamide on Serum Glucose and Lipid Profile in Alloxan-induced Diabetic Rats


Affiliations
1 Department of Biochemistry, University of Port Harcourt, Rivers State, Nigeria
2 Department of Medical Biochemistry, Niger Delta University, Bayelsa State, Nigeria
 

This study was aimed at comparing the antidiabetic and antihyperlipidemic activities of various doses (100,150, 200mg/kg body weight) of crude ethanol extract of Bryophyllum pinnatum and Glibenclamide (a reference drug). Thirty adult male rats (Wistar strain) weighing between 170-200g were used in this study. After 14 days of treatment, the rats were sacrificed and blood collected from the jugular vein was analysed accordingly. Results obtained showed that there were no significant differences (PBryophyllum pinnatum and the reference drug in serum glucose, total cholesterol, triglycerides, and low density lipoprotein cholesterol (LDL) levels. All doses of the extract of Bryophyllum pinnatum and the reference drug increased the levels of high-density lipoprotein cholesterol (HDL) but the increase were not significant (PBryophyllum pinnatum. Extracts of Bryophyllum pinnatum may thus help in the management of diabetes mellitus and its related complications.

Keywords

Diabetes Mellitus, Alloxan, Bryophyllum pinnatum, Lipid Profile and Atherogenic Index
User
Notifications

  • Chase SL (2002) New lipid guidelines recommend tighter control. Adv. Practice Nursing e-J. 2,1-9.

  • Fuller JH (1985) Epidemiology of hypertension associated with diabetes mellitus. Hypertension 7,113- 117.

  • Ginsberg HN (2000) Insulin resistance and cardiovascular disease. J. Clin. Invest. 106, 453-458.

  • Jelodar GA, Maliki M, Motadayen MH and Sirus S (2005) Effect of fenugreek, onion and garlic on blood glucose and histopathology of pancreas of alloxan induced diabetic rats. Indian J. Med. Sci. 59, 64-69

  • Jeppesen J, Hein HO and Suadicani P (1997) Relation of high TG-low HDL cholesterol and LDL

  • cholesterol to the incidence of ischemic heart disease, and 8 years follow-up in the Copenhagen male study. Arterioscler. Thromb. Vasc. Biol. 17, 1114-1120.

  • Kover MG, Harris MI and Hadden WC (1987) The scope of diabetes mellitus in the United States

  • Population. Am.J. Public Health. 77, 1547-1550.

  • Lange W and Foye W (1956) Metalchelate of alloxan. In physical pharmacy (3rd ed). Lea and Febiger Philadelphia, USA. pp: 343.

  • Lee WL, Cheung AM, Cape D and Zinman B (2000). Impact of diabetes on coronary artery disease in women and men. Diabetes Care. 23, 963-968.

  • Lenzen S, Tiedge M, Jorn A and Munday R (1996) Alloxan derivatives a tool for elucidation of the

  • mechanism of the diabetogenic action of alloxan: in lessons for animal diabetes. E. Shafrir (ed). Boston, Birkhauser. pp: 113-122.

  • Marriage PB and Wilson BG (1971) Analysis of the organic acids of Bryophyllum pinnatum. Can. J. Biochem. 49, 282-295.

  • Miranda PJ, DeFronzo RA, Califf RM, Guyton JR (2005). Am. Heart J. 149 (1), 33-45.

  • Murray RK, Granner, DK, Mayes PA and Rodwel VW (2000) Haper’s Biochemistry (25th ed). McGraw Hills.

  • Nwabuise C (2002) Prophylactic effect of multi-herbal induced in mice. East Afr. Med. J. 79(7),343-346.

  • Odetola AA and Bolarinde AO (1997) Assessment of acclaimed antidiabetic and antihypertensive property of mistletoe (Tapinanthus bangiwensis) in normal and alloxan induced diabetic rats. West African J. Biol. appl. Chem. 42, 41-44.

  • Okwu DE and Nnamdi FU (2011) Two novel flavonoids from Bryophyllum pinnatum and their antimicrobial activity. J. Chem. Pharmaceuti. Res. 3(2), 1-10.

  • Osadebe PO and Ajali U (2001) Antidiabetic activity ethanol extract of crude dried Aloe barbadensis (Linn) plant. Nigerian J. Biochem. Mol. Biol. 16(3), 795-815.

  • Penny MK, Karri DH, Andrea B, Stacie MC, Amy EB, Kirsten FH, Amy EG and Terry DE (2002) Bioactive compounds in foods: their role in the prevention of cardiovascular disease and cancer. Expert Medica. Incoporation.

  • Raintree Nutrition (2004) www.raintree.com (retrieved on 19/3/2005).

  • Scheen JA (1990) Drug treatment of non-insulin dependent diabetes mellitus in the 1990’s,

  • achievement and future development. Drugs.54, 355- 368.

  • Sofowora A (1993) Medicinal plants and traditional medicine in Africa. Spectrum books Ltd. Ibadan, Nigeria. pp: 191-289.

  • Tiwari AK and Malthusudana R (2002) Diabetes mellitus and multiple therapeutic approaches.

  • Phytochemicals; Present status and future prospects. Curr. Sci. 83, 30-38.

  • Trevedi NA, Mazumdar B, Bhatt JD and Hemavathi JDK (2004) Effect of Schilajit on blood glucose and lipid profile in alloxan induced diabetic rats. Indian J. Pharmacol. 36,373

  • Ufelle SA, Ukaejiofor EO, Neboh EE, Achukwu PU, Ghasi S, Ikekpeazu EJ and Maduka IC (2011) The

  • effect of crude methanolic leaf extract of Bryophyllum pinnatum on some haematological parameters in wistar rats. Asian J. Med. Sci. 3 (3), 121-124.

  • Uhegbu FO and Ogbuehi KJ (2004) Effect of aqueous extract (crude) of leaves of Vernonia amygdalina (DEL) on blood glucose and serum albumin and cholesterol levels of diabetic albino rats. Global J. Pure & Appl. Sci. 10(1), 189-194.

  • Yadav RNS and Agarwala M (2011) Phytochemical analysis of some Medicinal Plants. J. Phytology. 3(12), 10-14.

  • Yamamoto K, Miyagawa J, Hoh N, Nakajima H and Waguri M (1991) Differentiation of cells from ductal cells and acceleration of this process by nicotinamide, ultra structure study on the non obese diabetics (NOD) mouse with overt diabetes. Biomed. Res. Toky. 18, 171- 178.

  • Arokiyaraj S, Radha R, MartinS and Perinbam K (2008) Phytochemical analysis and anti-diabetic activity of Cadaba fruticosa R.Br. Ind.J.Sci.Technol. 1(6), 1-4. http://www.indjst.org.

  • Akansha Mishra, Jaitly AK and Arvind K Srivastava (2009) Antihyperglycaemic activity of six edible plants in validated animal models of diabetes mellitus. Ind. J. Sci. Technol. 2 (4), 80-86. http://www.indjst.org.

  • Rehan Ahmad, Swayam Prakash Srivastava, Rakesh Maurya SM, Rajendran KR, Arya and Arvind K Srivastava (2008) Mild antihyperglycaemic activity inEclipta alba, Berberis aristata, Betula utilis, Cedrus deodara, Myristica fragrans and Terminalia chebula. Ind.J.Sci.Technol. 1 (5), 1-6. http://www.indjst.org.

  • Priti Tiwari, Neha Rahuja, Rajesh Kumar, Vijay Lakshmi, Mahendra Nath Srivastava, Suresh Chandra Agarwal, Ram Raghubir and Arvind Kumar Srivastava(2008) Search for antihyperglycemic activity in few marine flora and fauna. Ind.J.Sci.Technol. 1( 5), 1- 5.http://www.indjst.org.


Abstract Views: 444

PDF Views: 426




  • Effects of Doses of Bryophylum pinnatum and Glibenclamide on Serum Glucose and Lipid Profile in Alloxan-induced Diabetic Rats

Abstract Views: 444  |  PDF Views: 426

Authors

E. D. Kpomah
Department of Biochemistry, University of Port Harcourt, Rivers State, Nigeria
E. M. Arhoghro
Department of Medical Biochemistry, Niger Delta University, Bayelsa State, Nigeria

Abstract


This study was aimed at comparing the antidiabetic and antihyperlipidemic activities of various doses (100,150, 200mg/kg body weight) of crude ethanol extract of Bryophyllum pinnatum and Glibenclamide (a reference drug). Thirty adult male rats (Wistar strain) weighing between 170-200g were used in this study. After 14 days of treatment, the rats were sacrificed and blood collected from the jugular vein was analysed accordingly. Results obtained showed that there were no significant differences (PBryophyllum pinnatum and the reference drug in serum glucose, total cholesterol, triglycerides, and low density lipoprotein cholesterol (LDL) levels. All doses of the extract of Bryophyllum pinnatum and the reference drug increased the levels of high-density lipoprotein cholesterol (HDL) but the increase were not significant (PBryophyllum pinnatum. Extracts of Bryophyllum pinnatum may thus help in the management of diabetes mellitus and its related complications.

Keywords


Diabetes Mellitus, Alloxan, Bryophyllum pinnatum, Lipid Profile and Atherogenic Index

References