Indian Journal of Drugs and Diseases

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Immunomodulatory Effect of Ocimum sanctum in Broilers Treated with High Doses of Gentamicin


 

The purpose of the study is to evaluate the immunomodulatory effect of Ocimum sanctum in broilers exposed to high dose of gentamicin which is common in poultry practice of Tamil Nadu. Two hundred and seventy day old broiler chicks of either sex were randomly divided into nine groups of 10 each with three replicates. Different doses of gentamicin (30mg/kg &50mg/kg) single intramuscular injection, different inclusion level of Ocimum sanctum crude extract (1 and 2 %) in feed and their combinations were tested. The results of the study revealed that gentamicin treatment produced significant reduction in serum total protein, albumin and globulin and numerical decrease in HI titre against Newcastle vaccine. The groups treated with Ocimum sanctum alone showed significant increase in all the above parameters. Dose dependent increase in all the parameters were noticed in the combination groups which clearly supports the immunoprotective effect of Ocimum sanctum.

Keywords

Ocimum sanctum, Gentamicin, Immunomodulation, Broiler
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  • Immunomodulatory Effect of Ocimum sanctum in Broilers Treated with High Doses of Gentamicin

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Abstract


The purpose of the study is to evaluate the immunomodulatory effect of Ocimum sanctum in broilers exposed to high dose of gentamicin which is common in poultry practice of Tamil Nadu. Two hundred and seventy day old broiler chicks of either sex were randomly divided into nine groups of 10 each with three replicates. Different doses of gentamicin (30mg/kg &50mg/kg) single intramuscular injection, different inclusion level of Ocimum sanctum crude extract (1 and 2 %) in feed and their combinations were tested. The results of the study revealed that gentamicin treatment produced significant reduction in serum total protein, albumin and globulin and numerical decrease in HI titre against Newcastle vaccine. The groups treated with Ocimum sanctum alone showed significant increase in all the above parameters. Dose dependent increase in all the parameters were noticed in the combination groups which clearly supports the immunoprotective effect of Ocimum sanctum.

Keywords


Ocimum sanctum, Gentamicin, Immunomodulation, Broiler

References