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A Study of Anti-hyperglycemic and Insilico Aldose Reductase Inhibitory Effect of Terpenoids of Euphorbia Antiquorum Linn. in Alloxan Induced Diabetic Rats


Affiliations
1 Department of Pharmaceutical sciences, Madras Medical College, Chennai-600003, India
 

Objective: To study the anti-hyperglycemic and aldose reductase inhibitory effect of Euphorbia antiquorum Linn. in Alloxan induced diabetic rats and molecular docking studies. Materials and methods: Diabetic rats were treated with 200 mg/kg of Ethanol, Petroleum ether and Aqueous extracts of E. antiquorum Linn. The blood glucose level was estimated for 8 hrs after drug treatment. Glide algorithm is used to dock the terpenoids Antiquol A, Antiquol B, and Antiquol C against the aldose reductase in standard precision mode. Results: The obtained results showed that all the extracts of E. antiquorum Linn., has hypoglycemic effect, the ethanol extract (69%) had more hypoglycemic effect which is comparable with standard drug Glibenclamide (80%). Molecular docking study reveals that Antiquol A was found to be one of the best aldose reductase inhibitor with glide score -9.07 kcal/mol. Conclusion: Our data conclude that the plant E. antiquorum has anti-diabetic as well as aldose reductase inhibitory effect.

Keywords

Euphorbia Antiquorum Linn, Diabetes Mellitus, Aldose Reductase, Terpenoids
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  • A Study of Anti-hyperglycemic and Insilico Aldose Reductase Inhibitory Effect of Terpenoids of Euphorbia Antiquorum Linn. in Alloxan Induced Diabetic Rats

Abstract Views: 600  |  PDF Views: 540

Authors

Amutha Periyasamy
Department of Pharmaceutical sciences, Madras Medical College, Chennai-600003, India
Kumar Nagarathinam
Department of Pharmaceutical sciences, Madras Medical College, Chennai-600003, India
Jayakumar Ponnusamy
Department of Pharmaceutical sciences, Madras Medical College, Chennai-600003, India
Karthikeyan Rajendren
Department of Pharmaceutical sciences, Madras Medical College, Chennai-600003, India

Abstract


Objective: To study the anti-hyperglycemic and aldose reductase inhibitory effect of Euphorbia antiquorum Linn. in Alloxan induced diabetic rats and molecular docking studies. Materials and methods: Diabetic rats were treated with 200 mg/kg of Ethanol, Petroleum ether and Aqueous extracts of E. antiquorum Linn. The blood glucose level was estimated for 8 hrs after drug treatment. Glide algorithm is used to dock the terpenoids Antiquol A, Antiquol B, and Antiquol C against the aldose reductase in standard precision mode. Results: The obtained results showed that all the extracts of E. antiquorum Linn., has hypoglycemic effect, the ethanol extract (69%) had more hypoglycemic effect which is comparable with standard drug Glibenclamide (80%). Molecular docking study reveals that Antiquol A was found to be one of the best aldose reductase inhibitor with glide score -9.07 kcal/mol. Conclusion: Our data conclude that the plant E. antiquorum has anti-diabetic as well as aldose reductase inhibitory effect.

Keywords


Euphorbia Antiquorum Linn, Diabetes Mellitus, Aldose Reductase, Terpenoids

References