Indian Journal of Drugs and Diseases

Open Access Open Access  Restricted Access Subscription Access

The Effect of some Antimalarial Drugs on Human Serum Lactate Dehydrogenase (LDH) Activity


Affiliations
1 Department of Biochemistry, University of Port Harcourt, PMB -5323, PHC, R/S, Nigeria
2 Department of Biochemistry, Madonna University, PMB-48, Elele, R/S, Nigeria
 

The invitro study on the effect of the antimalarial drugs; Chloroquine, Lariam, Camoquine, Quinine, Halfan and Fansidar on human serum lactate dehydrogenase activity was investigated at pH 7.5., results obtained revealed that chloroquine had little or no significant effect on the enzyme lactate dehydrogenase activity while others (lariam, camoquine, quinine, halfan, and fansidar) activated the enzyme in a concentration dependent manner.

Keywords

Drugs, Anti-malarial, Activity, Concentration, Enzyme, Inhibition, Diagnosis
User
Notifications

  • Burgen ASV and Mitchell JF (1979) Guddum’s Pharmacology, Oxford University Press.London. 8th Ed. pp: 214-217.

  • Cahn RD, Kaplan ND, Lavin L and Zwilling LE (1962) Mature and development of LDH.Sci. 136, 962-963.

  • Cheesbrough M (1989) Medical laboratory manual for tropical countries. 1, 2nd Ed. ButterworthHeinemann ltd, Oxford. pp: 518

  • Devlin MT (1986) Text book of biochemistry with clinical correlations. John Wiley and Sons Inc., 2nd Ed.

  • Lawrence DR., Bennett PN and Brown MJ (1946) Clinical Pharmacology (18th Ed.) Churchillliving stone (publish Edinburgh). pp: 238-245.

  • Norbert WT (1986) A text book of Clinical Chemistry.

  • Varley H, Gowenlock AH and Bell M (1984) Practical clinical biochemistry, (5th Ed.)Heinemann London. pp: 891-900.

  • Whitby LG, Percy-Robb IW and Smith AF (1980) Lecture notes on clinical chemistry (2nd Ed.)Blackwell scientific republications, London.


Abstract Views: 322

PDF Views: 313




  • The Effect of some Antimalarial Drugs on Human Serum Lactate Dehydrogenase (LDH) Activity

Abstract Views: 322  |  PDF Views: 313

Authors

E. Edeh Imomotimi
Department of Biochemistry, University of Port Harcourt, PMB -5323, PHC, R/S, Nigeria
A. A. Uwakwe
Department of Biochemistry, University of Port Harcourt, PMB -5323, PHC, R/S, Nigeria
N. C. Chinaka
Department of Biochemistry, Madonna University, PMB-48, Elele, R/S, Nigeria

Abstract


The invitro study on the effect of the antimalarial drugs; Chloroquine, Lariam, Camoquine, Quinine, Halfan and Fansidar on human serum lactate dehydrogenase activity was investigated at pH 7.5., results obtained revealed that chloroquine had little or no significant effect on the enzyme lactate dehydrogenase activity while others (lariam, camoquine, quinine, halfan, and fansidar) activated the enzyme in a concentration dependent manner.

Keywords


Drugs, Anti-malarial, Activity, Concentration, Enzyme, Inhibition, Diagnosis

References