Refine your search
Collections
Year
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
, Shanthakumari
- A Comparative Study of Lipid Profile in Chronic Alcoholics and Non Alcoholics in a Tertiary Care Hospital Bangalore, South India
Abstract Views :612 |
PDF Views:0
Authors
Affiliations
1 Department of Biochemistry, Sri Jayadeva Institute of Cardiovascular Science & Research Bangalore, Karnataka, IN
2 Department of Biochemistry, Karpaga Vinayaga Institute of Medical Science, Kanchipuram, Tamilnadu, IN
3 Department of Biochemistry, Dr B R Ambedkar Medical College, Bangalore, Karnataka, IN
4 Department of Community Medicine, S.S. Institute of Medical Sciences & Research Centre, Davangere, Karnataka, IN
5 Department of Biochemistry, Dr B R Ambedkar Medical College, Bangalore, Karnataka, IN
1 Department of Biochemistry, Sri Jayadeva Institute of Cardiovascular Science & Research Bangalore, Karnataka, IN
2 Department of Biochemistry, Karpaga Vinayaga Institute of Medical Science, Kanchipuram, Tamilnadu, IN
3 Department of Biochemistry, Dr B R Ambedkar Medical College, Bangalore, Karnataka, IN
4 Department of Community Medicine, S.S. Institute of Medical Sciences & Research Centre, Davangere, Karnataka, IN
5 Department of Biochemistry, Dr B R Ambedkar Medical College, Bangalore, Karnataka, IN
Source
International Journal of Contemporary Medicine, Vol 1, No 2 (2013), Pagination: 102-106Abstract
Background and Objectives: Alcoholism is a major threat to public health in both developed and developing countries. Over last 30-40 years alcohol consumption has increased in quantity and frequency. Alcohol use predisposes subjects to changes in lipid profile which are associated with coronary risk. Method: 30 alcoholic males were compared with 30 non alcoholic males. Alcohol drinking history was assessed by interview and questionnaire and lipid profile was done measuring total cholesterol, triglycerides, HDL, VLDL & LDL. Results: There were significant rise in TC, TGL ,HDL , LDL and VLDL of chronic alcoholics compared with non alcoholics with p value 0.001, <0.001, 0.004, 0.290, <0.001, respectively. Lipid profile was compared among moderate and heavy drinkers and found increased levels of TC, TGL, LDL & VLDL with p value <0.001, 0.001, 0.002 & 0.001 respectively in heavy drinkers. There is decrease in HDL cholesterol among heavy drinkers compared with moderate drinkers, p value 0.011 which is significant. But remains elevated compared to non alcoholics. Conclusion: This study shows that alcohol intake increases the level of lipid parameters. Moderate alcohol intake increases HDL cholesterol whereas heavy alcohol consumption increases TC,TGL,LDL & VLDL and decreases HDL.Keywords
Lipid Profile, Moderate Drinkers, Heavy Drinkers.
References
- J. Kishore’s National Health Programs of India, Pg. 384-385
- Morse & Flavin. The definition of alcoholism , August 26, 1993. 262 (8) :1012- 1014.
- Vaswani M, Rao RV. Biochemical measures in the diagnosis of alcohol dependence using discriminant analysis. Indian J Med Sci, 2005; Vol 59: 423-430.
- Sheila Sherlock and James Dooley. Alcohol and the Liver, Diseases of Liver and Biliary system,11th edition, Blackwell publications, London: 384-385.
- E Baraona and C S Lieber. Effects of ethanol on lipid metabolism.
- The Lancet vol 310, Issue 8030, 23. July 1977. Page 153-155
- Journal of lipid res. 1998. 39:2319-2328
- Drago S et al. study of lipid profile in chronic alcoholics. The indian practitioner 2002 Jan; 55(1):5-8.
- Biochemical measures in the diagnosis of alcohol dependence using discriminant analysis. Vol 59 oct 2005, No.10.
- Arun lakshmipathy et al. unusual lipid and metabolic abnormalities secondary to alcohol abuse Case report, Hospital Physician aug 2004.
- Lawrence Feinman and Charles S Lieber.Ethanol and lipid metabolism. American journal of clinical nutrition.
- Barboriak J J & R C Meade.1970. Effects of alcohol on gastric emptying in man. Am. J. Clin. Nutr.23: 1151-1153.
- Muller P, et al. Hypertriglyceridemia secondary to liver disease. Eur.J.Clin.Invest.4:419-428.
- Serum Levels of Renal Parameters in Light, Moderate and Heavy Drinkers: A Relation to Pattern of Alcohol Intake
Abstract Views :417 |
PDF Views:0
Authors
Affiliations
1 Department of Biochemistry, Karpaga Vinayaga Institute of Medical Sciences, Maduranthagam, Tamilnadu, IN
2 Department of Biochemistry, Sri Jayadeva Institute of Cardiology, Bangalore, Karnataka, IN
3 Department of Biochemistry, Dr. B.R. Ambedkar Medical College , Bangalore, IN
1 Department of Biochemistry, Karpaga Vinayaga Institute of Medical Sciences, Maduranthagam, Tamilnadu, IN
2 Department of Biochemistry, Sri Jayadeva Institute of Cardiology, Bangalore, Karnataka, IN
3 Department of Biochemistry, Dr. B.R. Ambedkar Medical College , Bangalore, IN
Source
International Journal of Contemporary Medicine, Vol 1, No 2 (2013), Pagination: 119-122Abstract
Objective: The purpose of this study was to detect serum levels of renal parameters in light, moderate and heavy drinkers and to evaluate the relation with pattern of alcohol intak.
Methods: 30 males of age 30-50 yrs with regular intake of alcohol for at least 10 yrs were selected and 30 normal male subjects with no history of drinking were selected for controls. The cases were further divided to light, moderate and heavy drinkers depending on pattern of alcohol intake. Renal parameters involve serum urea, creatinine and creatinine clearance.
Results: The study showed increase in serum urea and creatinine levels in heavy drinkers when compared to light and moderate drinkers and decrease in creatinine clearance in heavy drinkers.
Conclusion: The study shows an increase in urea and creatinine levels and decrease in creatinine clearance in heavy drinkers. This shows that pattern of alcohol intake alters the renal function.
Keywords
Urea, Creatinine, Creatinine Clearance, Light Drinkers, Moderate Drinkers, Heavy Drinkers.References
- Parry. Charles B. H, 2000. Alcohol problems in developing countries: Challenges for the millenium, Suchtmed 2(4) 216-220.
- Vaswani M, Rao RV. Biochemical measures in the diagnosis of alcohol dependence using discriminant analysis. Indian J Med Sci, 2005; Vol 59: 423-430.
- Sheila Sherlock and James Dooley. Alcohol and the Liver, Diseases of Liver and Biliary system, 11th edition, Blackwell publications, London: 384-385.
- M. N. Chatterjea, Rana Shinde. Diet and Nutrition, Textbook of Medical Biochemistry, 7th edition: 721-722.
- Alan H. Gowenlock. Varley’s Practical Clinical Biochemistry. Creatinine, Urate and Urea, 6th edition: 350-367.
- Tietz Nw, ed. Clinical guide to laboratory tests. 3 rd edition. 1995, Philadelphia, Saunders
- Lawrence A. Kaplan. Textbook of Clinical Chemistry Theory, Analysis, Correlation, 4th edition. Renal function: 477-492.
- Bernard Rosner (2000), Fundamentals of Biostatistics, 5th Edition, Duxbury, page 80-240
- Sunder Rao P S S, Richard J: An Introduction to Biostatistics, A manual for students in health sciences, New Delhi: Prentice hall of India. 86-160
- DM Vasudevan, Sreekumari. Textbook of Biochemistry. Minor metabolic pathways of carbohydrates, 4th edition: 115 – 126.
- DM Vasudevan, Sreekumari. Textbook of Biochemistry. Minor metabolic pathways of carbohydrates, 4th edition: 115 – 126.
- Eric L. Knight, Meir J. Stampfer et al. Moderate alcohol intake and renal function in women: a prospective study.2005.
- Elke S. Schaffner, Tobias Kurth et al. Alcohol consumption and the risk of renal dysfunction in apparently healthy men. Arch Intern Med; 165: 1048-1053.
- Majumdar SK, Shaw GK, O’ Gorman P et al. Plasma urea and creatinine status in chronic alcoholics. Drug Alcohol Dependence, 1982; 9(2): 97-100.
- Fu- Mei Chung, Yi Hsin Tien et al. Effect of alcohol consumption on estimated glomerular filtration rate and creatinine clearance rate. Nephrology Dialysis Transplant. 2005:1610-1616.