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Bhargava, Rahul
- Current Clinical Profile of Ocular HIV Disease in India
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Authors
Affiliations
1 Department of Pathology, Department of E.N.T., Santosh Medical College and Hospital, Ghaziabad, IN
2 Department of Ophthalmology, Department of E.N.T., Santosh Medical College and Hospital, Ghaziabad, IN
3 Department of E.N.T., Santosh Medical College and Hospital, Ghaziabad, IN
4 Department of Microbiology, Narayan Medical College and Hospital, Sasaram, IN
5 Rotary Eye Hospital Maranda, Palampur, HP, IN
1 Department of Pathology, Department of E.N.T., Santosh Medical College and Hospital, Ghaziabad, IN
2 Department of Ophthalmology, Department of E.N.T., Santosh Medical College and Hospital, Ghaziabad, IN
3 Department of E.N.T., Santosh Medical College and Hospital, Ghaziabad, IN
4 Department of Microbiology, Narayan Medical College and Hospital, Sasaram, IN
5 Rotary Eye Hospital Maranda, Palampur, HP, IN
Source
International Journal of Contemporary Medicine, Vol 1, No 2 (2013), Pagination: 52-58Abstract
Purpose: To describe current ophthalmic and systemic findings in 116 patients with Human Immunodeficiency Virus (HIV) infection examined at three referral eye centers in India and to establish safety guidelines for health care personnel's. Method: A complete ophthalmological examination was performed on each patient. Relevant investigations were carried out on selected patients. Results: The most common lesion was cytomegalovirus (CMV) retinitis. Other lesions in decreasing order of frequency are cotton-wool spots, chorioretinitis, endogenous endophthalmitis, anterior uveitis, and molluscum contagiousm. The most common systemic infection was pulmonary tuberculosis (50%). The others were oral candidiasis (41.4%), Pneumocystis carinii pneumonia (11.4%), HIV enteropathy (12.8%) and toxoplasmosis (4.2%). Conclusion: The most common ocular lesion among HIV patients in India is CMV retinitis. With wider availability of cost-effective HAART, clinical and epidemiological profile of HIV in India has undergone transition. Guidelines for aseptic measures in HIV infected patients have been clearly defined now. Physicians and Ophthalmologists should work in tandem to manage ocular disease and opportunistic infections.Keywords
Human Iimmunodeficiency Virus (HIV), Acquired Immune Deficiency Syndrome (AIDS), Highly Active aAntiretroviral Therapy (HAART), Cytomegalovirus (CMV).
References
- Fauci AS, Pantaleo G, Stanley S, Weissmann D. Immunopathogenic mechanisms of HIV infection. Ann Intern Med 1996; 124:654-63.
- Kumarasamy N, Solomon S, Flanigan TP, Hemalatha R, Thyagarajan SP, Mayer KH. Natural history of human immunodeficiency virus in southern India. Clin Inf Dis 2003; 16: 79-85.
- Simoes EA, Babu PG, John TJ, Nirmala S, Solomon S, Lakshminarayana CS, Quinn TC. Evidence for HTLV-III infection in prostitutes in Tamil Nadu (India). Indian J Med Res. 1987; 85: 335-8.
- Holland GS, Pepose JS, Pettit TH, Gottlieb MS, Yee RD, Foos RY. Acquired immune deficiency syndrome, ocular manifestations. Ophthalmology1983; 90: 859-73.
- Biswas J, Madhwan HN, George AE, Kumaraswamy N, Solomon S. Ocular lesions associated with HIV infection in India. A series of 100 consecutive patients evaluated at a referral center. Am J Ophthalmol 2000; 129: 9-15.
- Jabs D, Green WR, Fox R, Polk BF and Bartlett JG. Ocular manifestations of acquired immune deficiency syndrome. Ophthalmology 1989; 96:1092-99.
- Freeman WR, Lerner CW, Mines JA, Lash RS, Nadel AJ, Starr MB, Tapper ML. A prospective study of the ophthalmologic findings in acquired immune deficiency syndrome. Am J Ophthalmol 1984; 97:133-42.
- Kestelyn P, Van de Penre P, Rouvroy D, Lepage P, Bugaerts J, Nizaramba D et al. A prospective study of acquired immune deficiency syndrome in Africa. Am J Ophthalmol 1985; 100:230-8.
- Keselyn PG, Cunningham ET Jr. HIV/AIDS and blindness. Bull World Health Organ. 2001; 79:208- 213.
- Lewallen S, Courtright P. HIV/AIDS and the eye in developing countries. Arch Ophthalmol. 1997; 115:1291-1295.
- Hoover DR, Peng Y, Saah A, et al. Occurrence of cytomegalovirus retinitis after human immunodeficiency virus immunosuppression. Arch Ophthalmol 1996; 114:821-827.
- Biswas J, Joseph AE, Raizada S, Kumaraswamy N, Solomon S. Ophthalmic manifestations of acquired immunodeficiency syndrome in India. Ind J Ophthalmol 1999; 47: 87-93.
- Jabs DA. Ocular manifestations of HIV infection. Trans Am Ophthalmol Soc. 1995; 93: 623-83.
- Jabs DA. AIDS and Ophthalmology in 2004. Arch Ophthalmol 2004; 122: 1040-2.
- Deayton JR, Wilson P, Sabin CA et al. Changes in natural history of cytomegalovirus retinitis following the introduction of highly active antiretroviral therapy. AIDS 2000:14: 2593-6.
- Pauriah M, Ong EL. Retrospective study of CMV retinitis in patients with AIDS. Clin Microbiol Infect 2000; 6: 8-14.
- Jabs DA, Van Natta ML, Holbrook JT, Kempen JH, Meinert CL, Davis MD et al. Longitudinal study of ocular complications of AIDS. Ocular diagnosis at enrolment. Ophthalmology 2007; 114:780-6.
- Song MK, Azen SP, Buley A, Torriani F, Cheng L, Chaidhawangul S et al. Effects of anticytomegalovirus therapy on the incidence immune recovery uveitis in AIDS patients with healed cytomegalovirus retinitis. Am J Ophthalmol 2003; 136: 696-702.
- Karavellas MP, Azen SP, Macdonald JC, et al. Immune recovery vitritis and uveitis in AIDS: clinical predictors, sequelae, and treatment outcomes. Retina 2001; 21:1-9.
- Akduman L, Pepose JS. Anterior segment manifestations of acquired immune deficiency syndrome. Semin Ophthalmol 1995; 10:111-8.
- Jabs DA, Quinn TC. Acquired immune deficiency syndrome. In: Pepose JS, Holland GN, Wilhemus KR, eds. Ocular infection & immunity. St Louis: Mosby-Year Book, 1996:289-310.
- Shroff HJ, Dashatwar DR, Desponded RP, Waigmann HR. AIDS-associated Kaposi’s sarcoma in an Indian female. J Assoc Physicians India 1993; 41:241-2.
- Mselle J. Fungal keratitis as an indicator of HIV infection in Africa. Trop Doct 1999; 29: 133-5.
- Whitley RJ, Jacobson MA, Friedberg DN, Holland GN, Jabs DA, Dieterich DT et al. Guidelines for treatment of cytomegalovirus disease in patients with AIDS in the era of potent antiretroviral therapy. Arch Intern Med 1998; 158:957-69.
- Turner BJ, Hecht FM, Ismail RB. CD4+ Tlymphocyte measures in the treatment of individuals infected with human immunodeficiency virus type 1. A review for clinical practitioners. Arch Intern Med. 1994; 154:1 561-73.
- Cunningham ET Jr., Margolis TP. Ocular manifestations of HIV infection. N Engl J Med. 1998; 339:236-44.