Indian Journal of Bioinformatics and Biotechnology

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Carbon Distribution Accounts a Lot for Patterns in Proteins


Affiliations
1 Department of Bioinformatics, School of Biotechnology and Health Sciences, Karunya University, Coimbatore – 641114, Tamil Nadu, India
 

Background: Pattern is a set of amino acids forms a unit that governs protein structure and activity. So many developments have been made in retrieving these patterns using computational approach. From our recent findings it was concluded that carbon plays an important role in structure formation and binding. Method: Carbon distribution studies on these patterns are carried out using CARd program. The CARd outputs are plotted for comparison and discussed. Conclusion: The results reveal that carbon plays an important role in pattern formation. Carbon distribution based patterns account better over the amino acid patterns. That is different amino acid sequences are grouped as same pattern but in carbon distribution. In fact it is hoped for the refinement of pattern databases.

Keywords

Carbon Distribution, CARd, Conserved Sequences, Domain, Motif, Pattern, Sequence Analysis
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  • Anandagopu P, Suhanya S, Jayaraj V, Rajasekaran E (2008). Role of thymine in protein coding frames of mRNA sequences, Bioinformation, 2:304-307.

  • Jayaraj V, Suhanya R, Vijayasarathy M, Anandagopu P, Rajasekaran E (2009). Role of large hydrophobic residues in proteins, Bioinformation, 3:409-412.

  • Rajasekaran E (2012). CARd: Carbon distribution analysis program for protein sequences, Bioinformation, 8:508-512.

  • Rajasekaran E, and Akila K (2011). Adenine in viral mRNAs manipulate the carbon in proteins, International Journal of Bioscience, Biochemistry and Bioinformatics, 1:249-252.

  • Rajasekaran E, and Anandagopu P, (2010). Reduction of thymine in mRNA sequence of tumor protein, J. Advanced BioTech, 9:9-10.

  • Sigrist CJA, Cerutti L, de Castro E, Langendijk-Genevaux PS, Bulliard V, Bairoch A, Hulo N. (2010). PROSITE, a protein domain database for functional characterization and annotation, Nucleic Acids Res, 38:161-166.

  • Vinobha CS, and Rajasekaran E, (2011) Comparative analysis on large hydrophobic residues and small hydrophobic residues in different organisms, International Journal of Bioinformatics Research, 3:115-117.


Abstract Views: 516

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  • Carbon Distribution Accounts a Lot for Patterns in Proteins

Abstract Views: 516  |  PDF Views: 268

Authors

E. Rajasekaran
Department of Bioinformatics, School of Biotechnology and Health Sciences, Karunya University, Coimbatore – 641114, Tamil Nadu, India
K. Sheeba
Department of Bioinformatics, School of Biotechnology and Health Sciences, Karunya University, Coimbatore – 641114, Tamil Nadu, India

Abstract


Background: Pattern is a set of amino acids forms a unit that governs protein structure and activity. So many developments have been made in retrieving these patterns using computational approach. From our recent findings it was concluded that carbon plays an important role in structure formation and binding. Method: Carbon distribution studies on these patterns are carried out using CARd program. The CARd outputs are plotted for comparison and discussed. Conclusion: The results reveal that carbon plays an important role in pattern formation. Carbon distribution based patterns account better over the amino acid patterns. That is different amino acid sequences are grouped as same pattern but in carbon distribution. In fact it is hoped for the refinement of pattern databases.

Keywords


Carbon Distribution, CARd, Conserved Sequences, Domain, Motif, Pattern, Sequence Analysis

References