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Detection of Anti-Toxoplasma gondii Antibodies in Chronic Myeloid Leukemia and Acute Myeloid Leukemia Patients


Affiliations
1 Department of Parasitology, Iran University of Medical Sciences, Tehran, Iran, Islamic Republic of
2 Department of Parasitology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran, Islamic Republic of
 

Background and Aim: Infection of Toxoplasma gondii is a worldwide distribution. Toxoplasmosis in patients who are immunocompromised by virtue of underlying leukemia disease has received relatively little attention. This study was aimed to evaluate IgG and IgM antibodies of T. gondii and to minimize the role of T. gondii and opportunistic infection complication at the early stage of infection in leukemia patients.
Materials and Methods: The purpose of this assay was to measure anti-T. gondii IgG and IgM antibodies by enzyme-linked immunosorbent assay (ELISA) technique in leukemia patients.
Results: IgG antibodies against T. gondii were detected by ELISA in 96 (56.4%) leukemia patients and 72 (42.4%) control group. IgM antibodies were found in 10 patients (5.9%) with leukemia and 3 (1.8%) in the corresponding.
Conclusion: Our finding indicated that leukemia patients under immunosuppressive condition should not be neglected. Toxoplasmosis in leukemia patients as a main risk factor is considered, meanwhile in some patients, due to possibility of the presence of secondary infection that leads to severe toxoplasmosis.

Keywords

Acute Myeloid Leukemia, Chronic Myeloid Leukemia, Toxoplasma gondii.
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  • Detection of Anti-Toxoplasma gondii Antibodies in Chronic Myeloid Leukemia and Acute Myeloid Leukemia Patients

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Authors

Mohammad Javad Gharavi
Department of Parasitology, Iran University of Medical Sciences, Tehran, Iran, Islamic Republic of
Mona Roozbehani
Department of Parasitology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran, Islamic Republic of
Zienat Mandeh
Department of Parasitology, Iran University of Medical Sciences, Tehran, Iran, Islamic Republic of

Abstract


Background and Aim: Infection of Toxoplasma gondii is a worldwide distribution. Toxoplasmosis in patients who are immunocompromised by virtue of underlying leukemia disease has received relatively little attention. This study was aimed to evaluate IgG and IgM antibodies of T. gondii and to minimize the role of T. gondii and opportunistic infection complication at the early stage of infection in leukemia patients.
Materials and Methods: The purpose of this assay was to measure anti-T. gondii IgG and IgM antibodies by enzyme-linked immunosorbent assay (ELISA) technique in leukemia patients.
Results: IgG antibodies against T. gondii were detected by ELISA in 96 (56.4%) leukemia patients and 72 (42.4%) control group. IgM antibodies were found in 10 patients (5.9%) with leukemia and 3 (1.8%) in the corresponding.
Conclusion: Our finding indicated that leukemia patients under immunosuppressive condition should not be neglected. Toxoplasmosis in leukemia patients as a main risk factor is considered, meanwhile in some patients, due to possibility of the presence of secondary infection that leads to severe toxoplasmosis.

Keywords


Acute Myeloid Leukemia, Chronic Myeloid Leukemia, Toxoplasma gondii.