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Abdel-Ghani, Nour T.
- Potentiometric Flow Injection Analysis of Bromhexine Hydrochloride and its Pharmaceutical Preparation Using Conventional and Coated Wire Ion-selective Electrodes
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Authors
Affiliations
1 Chemistry Department, Faculty of Science, Cairo University, Giza, EG
1 Chemistry Department, Faculty of Science, Cairo University, Giza, EG
Source
Scientia Pharmaceutica, Vol 74, No 3 (2006), Pagination: 121-135Abstract
Bromhexine hydrochloride ion-selective electrodes (conventional type) based on bromhexinium tetraphenyl borate (I) and bromhexinium-phosphotungstate (II) were prepared. The electrodes exhibited mean slopes of calibration graphs of 59.4 mV and 59.8 mV per decade of bromhexine concentration at 25°C for electrode (I) and (II), respectively. Both electrodes could be used within the concentration range 3.16×10-5-1.00×10-2 M bromhexine within the pH range 2.0-4.5. The standard electrodes potentials were determined at different temperatures and used to calculate the isothermal coefficients of the electrodes, which were 0.00065 and 0.00050 V°C-1 for (I) and (II), respectively. The electrodes showed a very good selectivity for bromhexine with respect to a number of inorganic cations, amino acids and sugars. The electrodes were applied to the potentiometric determination of bromhexine hydrochloride and its pharmaceutical preparation under batch and flow injection conditions. Graphite, copper and silver coated wires were prepared, characterized and successfully applied as sensors for the drug under investigation.Keywords
Ion-selective Electrodes, Bromhexine Hydrochloride, Conventional And Coated Wire Electrodes, Flow Injection Analysis And Conductimetry.
References
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- Flow Injection Analysis With Trimetazidine Dihydrochloride Ion-Selective Electrode
Abstract Views :169 |
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Authors
Affiliations
1 Chemistry Department, Faculty of Science, Cairo University, Cairo., EG
1 Chemistry Department, Faculty of Science, Cairo University, Cairo., EG
Source
Scientia Pharmaceutica, Vol 73, No 4 (2005), Pagination: 173-193Abstract
New Plastic membrane ion-selective electrode for trimetazidine dihydrochloride based on trimetazidinium-tetraphenylborate was prepared. The electrode exhibited mean calibration graph slope of 29.5 mV per decade of (TrimCl2) concentration at 25°C. The electrode can be used within the concentration range 3.2 × 10-5-10-2M (TrimCl2) at pH ranges of 1.5-3.8 and 4.5-7.5. The standard electrode potentials were determined at different temperatures and used to calculate the isothermal coefficient of the electrode, which was (0.00088 V°C-1). The electrode showed a very good selectivity for (TrimCl2) with respect to a number of inorganic cations, sugars and amino acids. The electrode was applied to the potentiometric determination of the trimetazidine ion and its pharmaceutical preparation under batch and flow injection conditions. Graphite coated wire was prepared and characterized as sensor for the drug under investigation. Also, trimetazidine was determined by conductimetric titrations.Keywords
Trimetazidine Ion-Selective Electrode, Coated Graphite-Pencil Rod, Conductimetric Titrations and Flow Injection Analysis.References
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