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Aboul-Enein, M. Nabil
- Synthesis and Anticonvulsant Activitv of Certain N-Aralkyl-N-(1 Substituted Cyclohexyl) Benzenamines
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Authors
Affiliations
1 Dept. of Pharm. and Med. Chem., Pharm. Chem. Group, National Research Center, Dokki, Cairo, EG
2 Pharmaceutical Chemistry Dept., Faculty of Pharmacy, Cairo University, Cairo, EG
3 Dept. of Pharm. and Med. Chem., Pharmacol Group, National Research Center, Dokki, Cairo, EG
1 Dept. of Pharm. and Med. Chem., Pharm. Chem. Group, National Research Center, Dokki, Cairo, EG
2 Pharmaceutical Chemistry Dept., Faculty of Pharmacy, Cairo University, Cairo, EG
3 Dept. of Pharm. and Med. Chem., Pharmacol Group, National Research Center, Dokki, Cairo, EG
Source
Scientia Pharmaceutica, Vol 74, No 1 (2006), Pagination: 1-19Abstract
The synthesis of certain N-aralkyl(1-aminomethylcyclohexyl) benzenamines 6a-i, N-(a1kyloxymethyl or aral kyloxymethylcyclohexyl)-N-arylbenzenamines 9a-I and 1-(1-(aralkylphenylamino)cyclohexyl methoxy)-3-isopropylaminopropan-2-0ls 11a-c has been accomplished. These compounds exhibited anticonvulsant activity. Compounds 9h, 9b and 11a at doses 0.06, 0.075 and 0.08 mmol/kg, respectively provoked maximal anticonvulsant potential against pentylenetetrazol (PTZ) induced seizures test compared with diphenylhydantoin (0.2 mmol/kg) and valproic acid (0.24mmol/kg).Keywords
N-aralkyl-N(1-substitutedcyclohexyl)benzenamines, 1-(1- (aralkylphenyl amino)cyclohexylmethoxy)-3-isopropylaminopropan-2-ol, Anticonvulsant Activity.
References
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