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Abdellatef, H.
- Construction and Evaluation of Scopolamine Ion-Selective Electrode
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1 Analytical Chemistry Department, Faculty of Pharmacy - Zagazig University, Zagazig, EG
1 Analytical Chemistry Department, Faculty of Pharmacy - Zagazig University, Zagazig, EG
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Scientia Pharmaceutica, Vol 68, No 3 (2000), Pagination: 247-261Abstract
The construction of plasticised PVC matrix-type scopolamine ion-selective membrane electrode and its use in the potentiometric determination of scopolamine in pharmaceutical preparations are described. It is based on the use of the ion-associate species, formed by scopolamine cation and 5-nitrobarbituric counter ion. The basic electrode performance characteristics are evaluated according to IUPAC recommendations. It exhibited a linear response for 1×10-2-1×10-5 M of scopolamine solution with a cationic Nernstian slope over the pH range of 4-7 Common organic and inorganic cations showed negligible interference. Direct potentiometric determination of 1×10-2-1×10-5 M aqueous tubocurarine chloride using this membrane electrode system showed an average recovery of 99.05 with a mean standard deviation of 0.12. This electrode system was successfully applied to the potentiometric determination of scopolamine in some pharmaceutical preparations.Keywords
Scopolamine Membrane Electrode, Potentiometry, Pharmaceutical Analysis.References
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