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Abou-Attia, Fekria M.
- New Application of Chromotropic Acid for the Determination of some Sulphonamides in their Pharmaceutical Preparations
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Authors
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1 National Organization for Drug Control and Research P.O. Box 29 Cairo, EG
2 Faculty of Science, Cairo University, Giza, EG
3 Faculty of Science, Menoufia University, Shebin El-Kom, EG
1 National Organization for Drug Control and Research P.O. Box 29 Cairo, EG
2 Faculty of Science, Cairo University, Giza, EG
3 Faculty of Science, Menoufia University, Shebin El-Kom, EG
Source
Scientia Pharmaceutica, Vol 70, No 1 (2002), Pagination: 49-55Abstract
The formation of the azo-dye using chromotropic acid as a coupling agent was applied to the determination of five sulphonamides. The spectrophotometric studies as well as microanalysis of the studied sulphonamides-chromotropic acid azo dyes revealed the existence of the 1:1 coupling product. The absorbance of the formed azo dye is measured at 510 nm, and has a large molar absorptivity (ε = 2.87 - 3.29 × 104 1 mol-1cm-1). Beer's law was obeyed over the concentration range 0.5-9.0 μg ml-1. The assay results of pharmaceutical formulations showed good accuracy and precision over the concentration range used. The proposed method avoids time-consumption, extraction process and temperature control.Keywords
Sulphonamides; Chromotropic Acid; Azo Dyes; Spectrophotometry.References
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