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Abdel-Gawad, F. M.
- Spectrophotometric Determination of Some Pharmaceutical Piperazine Derivatives by Charge-Transfer and Ion-Pair Complexation Methods
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1 Faculty of Science, Cairo University, Giza, EG
2 National Organization for Drug Control and Research, Giza, EG
1 Faculty of Science, Cairo University, Giza, EG
2 National Organization for Drug Control and Research, Giza, EG
Source
Scientia Pharmaceutica, Vol 70, No 3 (2002), Pagination: 253-269Abstract
Simple and sensitive spectrophotometric methods are described for the assay of three piperazine derivatives ketoconazole, trimetazidine hydrochloride and piribedil based on cliarge-transfer and ion-pair complexation reactions. The first method is based on the reaction of the basic drug with iodine as σ-acceptor in dry 1,2-dichloroethane to form a yellow colour due to the formation of charge-transfer complex showing maximum absorbence at 363, 364 and 359 nm for ketoconazole, trimetazidine hydrochlorid and piribedil, respectively. The second method is based on the reaction of basic drug with bromocresol green (BCG) in dry 1,2-dichloroethane to form a stable yellow coloured complex with maximum absorbance at 407, 408 and 410 nm for ketoconazol, trimetazidine hydrochloride and piribedil, respectively. Beer's law was obeyed for both methods and the relative standard deviations were found to be less than 1%. The two methods can be applied for the analysis of tablets and cream, with no evidence of interference from excipients. A more detailed investigation of the complex was made with respect to its composition association constant and free energy change.Keywords
Ketoconazole, Trimetazidine Hydrochloride, Piribedil, Spectrophotometry, Charge-Transfer and Ion-Pair ComplexesReferences
- Heel R.C., Brodgen R.N., Carmine A., Amorley P., Speight T.M., Avery G. S. (1982), Drugs 1: 23.
- Odds F.C., Milne L.J. R., Gentles J.C., Ball E.H. (1980), J. Antimicrob. Cliemother. 6: 97.
- Pascucci V.L., Bennett J., Narang P.K., Chatterji D.C. (1983), J. Pliann. Sci. 72: 1467.
- United States Pharmacopeia XXIII, N.F. XVIII, US Pharmacopeial Convention, Inc., MD, (1995), p. 865.
- Abounassif M.A., El-Shazly B.E.D.M. (1990), Anal. Lett. 22: 2233.
- Roa G.R.., Roa P.J., Murty S.S.N. (1988), Indian Drugs 25: 119.
- Zarapkar S.S., Halkar U.P. (1991), Indian Drugs 28: 265.
- Abdelmageed O.H., Khashaba P.Y. (1993), Talanta 40: 1289.
- San R.T., Tendolkar R.V., Gangal D.P., Ladage K.D., Kothurkar R.M.(1988), Indian J. Pharm. Sci. 50: 347.
- Sadeghi S., Shamsipur M. (1998), Anal. Lett. 31: 2691.
- Shabouri S. R., Emara K.M., Khashaba P.Y., Mohamed A.M. (1998), Anal. Lett. 31: 1367.
- Abdel-Gawad F.M. (1997), I1 Farmaco 52: 119.
- Abdel-Gawad F.M. (1997), J. Pharm. Biomed. Anal. 15: 1679.
- Fijalek Z,, Chodkowski J., Warowna M. (1992), Acta Pol. Phm. 49: 1.
- Roychowdhury U., Das S.K. (1996), J. AOAC Int. 79: 656.
- Hoffman D. W., Jones-King K.L., Ravaris C.L. (1988), Anal. Biochem. 172: 495.
- Meshal M.A. Al. (1990), Anal. Lett. 22: 2249.
- Dipietra R.M., Cavrini V., Andrisano V., Gatti R. (1992), J. Pharm. Biomed. Anal. 10: 873.
- Dai F., Li L. (1990), Yaowu Fenxi Zazhi 10: 232, in (1990), A.A. 52: 12E 82.
- Jiang Z., Weng X., Lu L. (1990), Yaowu Fenxi Zazhi 10: 161, in (1990), A.A. 52: 12D 107.
- Selinger K., Matheou D., Hill H.M. (1988), J. Chromatogr. 434: 259.
- Yuen K.H., Peh K.K. (1998), J. Chromatogr. 715: 436.
- Kedor-Hackmann E.R.M., Nery M.M.F., Santoro M.I.R.M. (1994), Anal. Lett. 27: 363.
- Harpey C., Clauser P., Labrid C., Freyria J.L., Poirier J.P. (1989), Cardiovasc. Drug Rev. 6: 92.
- Naito S.I., Osumi S., Sekisshiro K., Hirose M. (1972), Chem. Pharm. Bull. 20: 682.
- Courte S., Bromet N. (1981), J. Chromatogr. Biomed. Appl. 224: 162.
- Bari V.R., Dhorda U.J., Sunderesan M. (1999), Indian Drugs 36: 289.
- Fay L., Michel G., Goupit P., Harpey C., Prost H. (1989), J. Chromatogr. Biomed. Appl. 490: 198
- Thoppil S.O., Cardoza R.M., Amin P. D. (2001), J. Pharm. Biomed. Anal. 25: 15.
- Regnier G.L., Canevari R. J., Laubie M.J., Le Douarec J.C. (1968), J. Med. Chem. 11: 1151
- Dourish C.T. (1983), Prog. Neuro-Psychopharmacol. Biol. Psychiatry 7: 3.
- Janner P., Taylor A.R., Campbell D.B. (1973), J. Pharm. Pharrnacol. 25: 749.
- Fanelli R., Frigerio A. (1974), J. Chromatogr. 93: 441.
- Abdel-Gawad F.M. (1998), J. Pharm. Biomed. Anal. 16: 793.
- Sarati S., Guiso G., Spinelli R., Caccia S. (1991), J. Chromatogr. 563: 323.
- Issa Y.M., Hassouna M.M., Abdel-Gawad F.M., Hussien E.M. (2000)., J. Pharm. Biomed. Anal. 23: 493.
- Job P. (1928), Ann. Chim. Phys. 9: 113.
- Henery S.I.T., Eric D.G., Anthony S.D. (1977), J. Pharm. Sci. 66: 766.
- Taha A.M., El-Rabbat N.A., Abdel-Fattah F.A. (1980), Analyst 105: 568.
- Belal S., Elsayed A.M., Abdel-Hamid M.E., Abdine H. (1980), Analyst 105: 774.
- El-Walily A.M., El-Gindy A., Wahbi A.M. (1995), J. Pharm. Biomed. Anal. 13: 53.
- Saleh G.A., Askal H.F. (1991), J. Pharm. Biomed. Anal. 9: 219.
- Foster R. (1969), Selected Charge- Transfer Complexes, Alfred T. Blomquiet, Organic Charge- Transfer Compexes, Academic Press, London and New York, p.276.
- Tan H.S.I., Gerlach E.D., Dimatto A.S. (1977), J. Pharm. Sci. 66: 766.
- Comby F., Absil A., Buxeraud J., Roby C. (1989), Chem. Pharm. Bull. 37: 151.
- Popov A.I., Deskin W. (1958), J.Am. Chem. Soc. 80: 2976.
- Vytras K., Batova H., Janousek V. (1989), Analyst 114: 479.
- Benesi H.A., Hildebrand J. (1949), J. Am: Chem. Soc. 71: 270.
- Ringbom A. (1939), Z. Anal Chem. 115: 332.
- The European Agency for the Evaluation of Medical Products, ICH Topic Q2B Note for Guidance on Validation of Analytical Procedures; Methodology CPMP/ICH/281/95, (1996).
- Japanese Pharmacopoeia, 13th Ed., The Society of Japanese Pharmacopoeia, Tokyo (1996), p. 693.