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Abu Zuhri, Ali Z.
- Extractional - Spectrophotometric Determination of Fenbendazole and Ornidazole in Pharmaceutical Formulations
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Authors
Affiliations
1 Chemistry Department, and Medical Tech. Department, An-Najah National University, Nablus, PS
2 Abteilung fuer Physikalische Biochemie des Physiologisch Chemisches Instituts der Universitaet Tuebingen, Hoppe-Selyer Strasse 4, D-72076 Tuebingen, DE
1 Chemistry Department, and Medical Tech. Department, An-Najah National University, Nablus, PS
2 Abteilung fuer Physikalische Biochemie des Physiologisch Chemisches Instituts der Universitaet Tuebingen, Hoppe-Selyer Strasse 4, D-72076 Tuebingen, DE
Source
Scientia Pharmaceutica, Vol 68, No 1 (2000), Pagination: 109-122Abstract
Methods for spectrophotometric determination of fenbendazole and ornidazde are described. The methods are based on the formation and extraction of the ion-pair complex formed between bromothymol blue and either fenbendazole (FBZ) or ornidazole (ORN). The extracted coloured complexes absorb at 416 and 446 nm , respectively. The effect of different factors, e.g. pH, organic solvent, reagent concentration, extraction time, shaking time and common interfering species have been investigated. Fenbendazole and ornidazole can be determined over the range 1.2 to 24.0 ppm and 5.5 to 77.0 ppm, respectively. The precision of the methods was tested for the determination of pure samples of FBZ and ORN and the mean RSD was found to be 3.0 and 2.3% for FBZ and ORN, respectively. The proposed methods were successfully applied for the determination of FBZ and ORN in commercially dosage forms. A comparison between the suggested methods and the other reported methods was also studied.Keywords
Spectrophotometric Determination; Fenbendazole; Ornidazole; Pharmaceutical Formulations.
References
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- Ion-Pair Spectrophotometric Determination of Dibucaine
Abstract Views :155 |
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Authors
Affiliations
1 Faculty of Pharmacy, An-Najah National University, P.O.Box 7, Nablus, PS
2 Department of Postgraduate Studies, An-Najah National University, P.O.Box 7, Nablus, PS
1 Faculty of Pharmacy, An-Najah National University, P.O.Box 7, Nablus, PS
2 Department of Postgraduate Studies, An-Najah National University, P.O.Box 7, Nablus, PS
Source
Scientia Pharmaceutica, Vol 68, No 2 (2000), Pagination: 189-200Abstract
A simple and sensitive spectrophotometric determination of dibucain has been established. It is based on the formation of colored ion-pair complexes between Dibucaine and each of Orange 11, Orange G, Bromothymol blue and Bromocresol green. The extract with each of the previous dyes in chloroform exhibited a specific wavelength of maximum absorbance, and all these wavelengths lied in the range 416 to 500 nm. The linear range extended from 1.5 to 60 ppm. The optimum conditions were selected after studying many variables such as pH, shaking time, temperature and dye concentrations. The method was also selective for the analyte and the drug excipients did not interfere.Keywords
Dibucaine; Ion-Pair SpectrometryReferences
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