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Authors
Affiliations
1 Nigerian Institute for Trypanosomiasis Research (NITR), 1, Surame Road, Kaduna, Kaduna State, NG
2 Nigerian Stored Product Research Institute, Department of Microbiology and Biotechnology, Km 3 Asa dam road, P.M.B. 1489, Ilorin, Kwara State, NG
3 University of Ilorin, Department of Microbiology,P.M.B.1515,Ilorin, Kwara State, NG
Source
SMU Medical Journal, Vol 2, No 1 (2015), Pagination: 177-190
Abstract
The antimicrobial activities and preliminary phytochemical screening of methanolic extract of
Vitellaria paradoxa was performed against clinical isolates obtained from UITH which included
Staphylococcus aureus, Escherichia coli, Aspergillus niger and
Candida albicans. Leaf extracts of
Vitellaria paradoxa were prepared using methanol as solvent. The extracts were tested using agar diffusion and broth dilution method .
Escherichia coli was resistant to all the extracts of
Vitellaria paradoxa . Antimicrobial activity was recorded by the methanolic extract of
Vitellaria paradoxa with zone of inhibition of 19mm on
Candida albicans. The minimum inhibitory concentration of the extract ranged from 40mglml to 160mglml for
Vitellaria paradoxa leaf extract. Methanolic leaf extract of
Vitellaria paradoxa are found to be bactericidal and fungicidal on
Staphylococcus aureus and
Aspergillus niger, Candida albicans respectively.
Vitellaria paradoxaleaf extract contained saponin, tannins, flavonoid, phenolics, steroids, alkaloids, phlobatannins and glycoside.
The result from this study ,therefore suggest the possibility of using Vitellaria paradoxa extracts as antimicrobial agents, which can be a great asset to drug development for purpose of health care delivery in Nigeria
Keywords
Antimicrobial Activity, Minimum Inhibtory Concentration, Phytochemical , Vitellaria paradoxa.
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