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Okdeh, Malek M. S.
- New Method for Spectrophotometric Determination of Lidocaine
Abstract Views :448 |
PDF Views:181
Authors
Affiliations
1 Department of Chemistry, Techreen University, Lattakia, SY
1 Department of Chemistry, Techreen University, Lattakia, SY
Source
SMU Medical Journal, Vol 2, No 2 (2015), Pagination: 81-92Abstract
This work include prepration the organic reagent 3-hydroxy-4-[(4-hydroxyphenyl)azo]-1- naphthalenesulfonic acid by coupling diazonium of 1-amino-2-naphthol-4-sulfonic acid with phenol. The reagent react with Lidocaine in acidic medium( PH = 4) to produce red colored complex with mole ratio 1:1 (L:M) and maximum absorbance at 510 nm . this method show obey to beers in the range of 1.44 - 69.31 ppm, with molar absorptivity of 4.1633×103 L mole-1 cm-1 Sandell's sensitivity 0.0693 μg·cm-2 The effects of variables such as pH, time, concentration of color producing reagent, and stability of color were investigated to optimize the procedure. The results are validated statistically. The proposed method was applied to commercially available tablets, and the results were Pharmaceutical formulations.Keywords
Lidocaine, Determination, Spectrophotometry.Full Text
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- New Spectrophotometric Determination of Hydralazine Hydrochloride in Pure form and Pharmaceutical Formulation using Potassium Ferrocyanide
Abstract Views :206 |
PDF Views:120
Authors
Affiliations
1 Chemistry Department, Tichreen University, Lattakia, SY
1 Chemistry Department, Tichreen University, Lattakia, SY
Source
SMU Medical Journal, Vol 4, No 1 (2017), Pagination: 72-78Abstract
Simple and selective method for the determination of hydralazine Hydrochloride in pharmaceutical formulation is described. The procedure is based on the formation of colored complex with potassium ferrocyanid. Different variables affecting the complex formation were studied and optimized. The method was used to determine 1.90-68μgmL-1 of hydralazine Hydrochloride in the Final measured solution. The simplicity of the method permits rapid analysis and thus suitable for routine control.
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