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In vitro Anti Thiamine Activity of an Isolated Compound from Murrya koenigii (linn.) Spreng Wettst Leaves:Effect of Season


Affiliations
1 Department of Biochemistry, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India
2 Department of Medical Biotechnology, Sikkim Manipal Institute of Medical Sciences, Gangtok, Sikkim, India
 

By solvent extraction, acid hydrolysis, chromatographic experiments followed by crystallization a compound was isolated from Murrya koenigii (Linn.) Spreng Wettst leaves. The compound could exert anti thiamine activity in in vitro experiment. It was found out that 1g of the compound inactivated 31.8 mg of thiamine hydrochloride in 1 h. Effect of season on in vitro anti thiamine activity of the compound was also studied. Results showed that compound isolated from the leaves of Murrya koenigii (Linn.) Spreng Wettst of the period July - August had maximum anti thiamine activity.


Keywords

Murrya koenigii (Linn.) Spreng Wettst Leaves, Anti Thiamine Activity, Seasonal Variation.
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  • In vitro Anti Thiamine Activity of an Isolated Compound from Murrya koenigii (linn.) Spreng Wettst Leaves:Effect of Season

Abstract Views: 315  |  PDF Views: 148

Authors

Prasenjit Mitra
Department of Biochemistry, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India
Tanaya Ghosh
Department of Medical Biotechnology, Sikkim Manipal Institute of Medical Sciences, Gangtok, Sikkim, India
Prasanta Kumar Mitra
Department of Medical Biotechnology, Sikkim Manipal Institute of Medical Sciences, Gangtok, Sikkim, India

Abstract


By solvent extraction, acid hydrolysis, chromatographic experiments followed by crystallization a compound was isolated from Murrya koenigii (Linn.) Spreng Wettst leaves. The compound could exert anti thiamine activity in in vitro experiment. It was found out that 1g of the compound inactivated 31.8 mg of thiamine hydrochloride in 1 h. Effect of season on in vitro anti thiamine activity of the compound was also studied. Results showed that compound isolated from the leaves of Murrya koenigii (Linn.) Spreng Wettst of the period July - August had maximum anti thiamine activity.


Keywords


Murrya koenigii (Linn.) Spreng Wettst Leaves, Anti Thiamine Activity, Seasonal Variation.