Genotoxic Effects of GSTP1 Gene Polymorphisms with Respect to Respiratory Problems among Traffic Police

Genetic susceptibility is likely to play a role in response to vehicular pollution of GSTP1 and NAT2 (C481T). Genotoxic effects due to respiratory problems in traffic police occupationally exposed to vehicular exhaust have particular importance in the detoxification of inhaled toxicants since it is the most abundant in the lung function and the association.161 male traffic policemen and 170 control subjects were selected for this study. Gene polymorphism was studied using PCR and RFLP method. The results on gene polymorphism of GSTP1 and NAT2 (C481T) showed significant association of homozygous mutant genotype (GG) in GSTP1 gene and homozygous mutant genotype (CC) in NAT2 gene with traffic police having respiratory problems. However, no such association was observed in traffic police without respiratory problems and control group also. Our results suggest that long term exposure to urban air pollution (with traffic as the main contributor) polymorphisms in genetic susceptibility provides evidence to suggest a role in determining the respiratory problems in GSTP1 and NAT2 (C481T) variants associated with reduced detoxification ability, increase susceptibility to such damage and appears to be associated with occupationally exhaust vehicular exhaust in traffic policemen.