South Indian Journal of Biological Sciences

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Hepatoprotective Activity of Ethanolic Extract of Alysicarpus vaginalis against Nitrobenzene-Induced Hepatic Damage in Rats


Affiliations
1 Department of Biochemistry, Sree Narayana Guru College, Coimbatore-641 021, Tamil Nadu, India
2 Department of Soil Science and Agricultural Chemistry, Anbil Dharmalingum Agricultural College and Research Institute, Trichy 620009, Tamil Nadu, India
3 Department of Biochemistry, Karpagam University, Coimbatore 641 021, Tamil Nadu, India
 

Alysicarpus vaginalis (L.) DC commonly known as Alyce clover, belongs to the botanical family Fabaceae. It is widely distributed in India, Pakistan, Sri Lanka , Africa and Australia. In India it is traditionally used by the tribals for diuretics, leprosy, pulmonary troubles and back pain. The present study aimed to evaluate the hepatoprotective activity of ethanol extract of A. vaginalis aerial parts in nitrobenzene (NB) induced hepatic injury in Wistar rats. Liver injury was induced in rats by single oral administration of of NB (50 mg/kg bw). One days after NB induction, the rats were treated with ethanolic extract of A. vaginalis orally at the doses of 200 mg/kg bw daily for 30 days. Silymarin (25 mg/kg bw orally) was used as reference drug. After 30 days serum biochemical parameters, antioxidant enzyme status and histopathological parameters were analyzed. The results indicated that the ethanol extract of A. vaginalis the doses of 200 mg/kg orally significantly (P<0.05) and dose-dependently reduced and normalized the serum marker enzymes, and increased the antioxidant enzyme status as compared to that of NB control group. Further more it was confirmed by histopathological studies. This study concludes that A. vaginalis demonstrated promising hepatoprotectivity agent in NB induced hepatic damaged rats.

Keywords

Alysicarpus vaginalis, Antioxidant Enzymes, Liver Injury, Liver Marker Enzymes, Nitrobenzene.
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  • Hepatoprotective Activity of Ethanolic Extract of Alysicarpus vaginalis against Nitrobenzene-Induced Hepatic Damage in Rats

Abstract Views: 223  |  PDF Views: 4

Authors

Muthaiyan Ahalliya Rathi
Department of Biochemistry, Sree Narayana Guru College, Coimbatore-641 021, Tamil Nadu, India
Periasamy Meenakshi
Department of Soil Science and Agricultural Chemistry, Anbil Dharmalingum Agricultural College and Research Institute, Trichy 620009, Tamil Nadu, India
Velliyur Kanniappan Gopalakrishnan
Department of Biochemistry, Karpagam University, Coimbatore 641 021, Tamil Nadu, India

Abstract


Alysicarpus vaginalis (L.) DC commonly known as Alyce clover, belongs to the botanical family Fabaceae. It is widely distributed in India, Pakistan, Sri Lanka , Africa and Australia. In India it is traditionally used by the tribals for diuretics, leprosy, pulmonary troubles and back pain. The present study aimed to evaluate the hepatoprotective activity of ethanol extract of A. vaginalis aerial parts in nitrobenzene (NB) induced hepatic injury in Wistar rats. Liver injury was induced in rats by single oral administration of of NB (50 mg/kg bw). One days after NB induction, the rats were treated with ethanolic extract of A. vaginalis orally at the doses of 200 mg/kg bw daily for 30 days. Silymarin (25 mg/kg bw orally) was used as reference drug. After 30 days serum biochemical parameters, antioxidant enzyme status and histopathological parameters were analyzed. The results indicated that the ethanol extract of A. vaginalis the doses of 200 mg/kg orally significantly (P<0.05) and dose-dependently reduced and normalized the serum marker enzymes, and increased the antioxidant enzyme status as compared to that of NB control group. Further more it was confirmed by histopathological studies. This study concludes that A. vaginalis demonstrated promising hepatoprotectivity agent in NB induced hepatic damaged rats.

Keywords


Alysicarpus vaginalis, Antioxidant Enzymes, Liver Injury, Liver Marker Enzymes, Nitrobenzene.



DOI: https://doi.org/10.22205/sijbs%2F2015%2Fv1%2Fi2%2F100420