Research Journal of Science and Technology

Bhaskar S. Dawane ¹, Santosh S. Chobe ², Santosh N. Kinkar ¹, Gajanan G. Mandawad ¹, Omprakash S. Yemul ¹, Rahul D. Kamble ¹, Anil V. Shinde ¹

Affiliations
1 School of Chemical Sciences, Swami Ramanand Teerth Marathwada University, Vishnupuri, Nanded - 431606 (M.S.), IN
2 School of Chemical Sciences, Swami Ramanand Teerth Marathwada University, Vishnupuri, Nanded-431606 (M.S.), IN

Abstract

Synthesis of bis(indolyl) methanes by the reaction of indoles with structurally diverse aldehydes and cyclohexanone in the presence of catalytic amount of bleaching earth in polyethylene glycol (PEG-400) as green solvent afforded the corresponding bis(indolyl) methanes in excellent yields. The effects of solvent, nature of substituents on the aromatic ring of aldehydes were investigated. The catalysts and solvent were reusable up to 4 times without significant loss of activity. The remarkable features of this procedure are high conversions, shorter reaction time and cleaner reaction profiles.

Keywords

Bleaching Earth Clay, PEG-400, Indole, Aldehydes, Bis (Indolyl) Methane.

Full Text