https://www.i-scholar.in/index.php/Rjst/issue/feed Research Journal of Science and Technology 2023-02-27T15:22:29+00:00 Dr. Mrs. Monika S. Daharwal avpublications@gmail.com Open Journal Systems <div id="i-scholarabout">Research Journal of Science and Technology (RJST) is an international, peer-reviewed journal, devoted to science and technology. The aim of publishes Original Research Articles, Short Communications, Review Articles in all areas of Science and Technology.</div> https://www.i-scholar.in/index.php/Rjst/article/view/218993 Synthesis of some Novel Benzimidazole-Oxothiazolidine Derivatives as Anti-Tubercular agents: Conventional Vs Microwave Assisted Approach 2023-02-27T15:22:29+00:00 Sonal Dubey drsonaldubey@gmail.com Sakshi Bhardwaj N-(4-alkyl-4-oxo-1,3-thiazolidin-3-yl)-2-(5-nitro-1H-benzimidazole-1-yl)acetamide derivatives were designed and synthesis. Twelve novel derivatives were synthesized using conventional approach and Microwave-assisted synthesis. Herein we report the comparisonbetween the two approaches in terms of time, solvents used and yield. As evident from the results obtained the green chemistry approach for the synthesis is the more efficient way of synthesis in terms of time and yield. The synthesized compounds were subjected to anti tubercular Alamar Blue Assay. Some of them have shown promising activity. 2022-12-31T00:00:00+00:00 https://www.i-scholar.in/index.php/Rjst/article/view/218995 Evaluation of Anti-oxidant properties of some medicinal plant products by ABTS Radical Scavenging Assay 2023-02-27T15:22:29+00:00 Kavya Kulkarni kavyakulkarni@gmail.com Govindaiah Antioxidant properties of plant products Cumin, Cinnamon, Pepper, Clove, and Star anise were measured against Quercetin as control by ABTS radical scavenging assay. The absorbance is recorded at 734nm, and percent inhibition is calculated at different concentrations of the sample. Graph pad prism method is used to calculate the IC<sub>50</sub> values. A comparative account is tabulated in the study for the afore-mentioned plant products. Among the tested samples, Cinnamon has exhibited the highest IC50 value being 142 in chloroform extracts and the lowest being 18.09 is of star anise in methanol extracts. 2022-12-31T00:00:00+00:00 https://www.i-scholar.in/index.php/Rjst/article/view/218994 Synthesis of N-Mannich Bases of some Substituted Carbazoles 2023-02-27T15:22:29+00:00 Neetu Verma Shruti Awasthi Vikrant Jain dr_vikrantjain@yahoo.in Through reactions with numerous secondary amines and a series of aldehydes, including formaldehyde and acetaldehyde, novel carbazole derivative conjugates were created from carbazole. Corresponding analogues were identified through spectral studies, and they were tested for their ability to reduce pain and control seizures using the Eddy's Hot Plate method and the maximum electrical shock convinced convulsion method, respectively. Students created the statistical analysis using the "t" test, and the standards were stated as mean SEM. 2022-10-01T00:00:00+00:00 https://www.i-scholar.in/index.php/Rjst/article/view/218996 Prevalence of Peri Implantitis using Intraoral and Extra Oral Imaging in patients visiting a Dental hospital 2023-02-27T15:22:29+00:00 Shamaa Anjum 151701014.sdc@saveetha.com Manjari Chaudary manjaric.sdc@saveetha.com Ostial resorption occurs after the placement of implant fixture upto first third of the implant fixture body or to first contact of the alveolar applied to imagine anatomic structure like alveolar bone. To Evaluate periimplantitis using intra oral and extra oral imaging. The data of patients at stage 2 review after implant placement was collected from Dental Information Archiving Software. The collected data was tabulated and imported to SPSS for statistical analysis. The results of the current study shows that males are most likely to have bone loss. Patients of 31-40 years exhibited more bone loss. Orthopantomogram and Intra Oral Periapical Radiograph were good parameters for evaluation of successful implant and prognosis monitoring. 2022-12-31T00:00:00+00:00 https://www.i-scholar.in/index.php/Rjst/article/view/219014 Effect of Tree Leaf Litterfall on available Nutrients and Organic Carbon Pools of Soil 2023-02-27T15:22:29+00:00 K. K. Bhardwaj krishansoils@gmail.com M. K. Singh Dev Raj Sonia Devi Garima Dahiya S. K. Sharma M. K. Sharma A study was conducted to investigate the effect of leaf litterfall of shelterbelt, Azadirachta indica, Ailanthus excels and Prosopis cineraria and control (devoid of trees) on available nutrients and organic carbon pools of soil from 3 distances (2, 5 and 10m) The total litterfall during the study period ranged between 1712 and 4126kg/ha and it was found maximum in the month of January and it was minimum in February in different plantations. Annual litterfall showed considerable variation among different plantations. Litter accumulation under the different plantations canopy was highest in the shelterbelt followed by Prosopis cineraria and lowest in the Azadirachta indica. There was improvement in soil organic carbon, dissolved organic carbon, microbial biomass carbon, available macro (N, P and K) and micronutrients (Zn, Fe, Mn and Cu) tree species when compared to field without trees. Significant improvement in soil organic carbon (0.14 to 0.26 %), available N (55.9 to 116.6kg/ha) P (9.6 to 13.6kg/ha) and K (188.9 to 248.3kg/ha) was observed under these tree species compared to field without trees. The content of Zn, Cu, Fe and Mn and was 15, 25, 40 and 51 percent, respectively higher under these tree species than the control field. The amount of nutrients returned to the soils through litter was significantly highest at 2m distance under different plantations. The present study indicated that these available nutrients and organic carbon pools improved significantly across the different land use system. Due to intensive cultivation and monocropping, the fertility of soil is deteriorating day by day. Simultaneously it is creating a pressure on the natural resources like soil because the population is increasing day by day. Therefore, it is wise to use degraded and problematic soil for cultivation. Agroforestry systems have been recognized as an alternative for the rehabilitation of degraded areas and it provides ecosystem services and reduces human impacts on natural forests (Nair et al., 2009). Tree based land use systems have special role in reclamation of wastelands, use of poor-quality waters, organic carbon build up and moderating climate change related risks. In areas of Haryana and Rajasthan trees like Prosopis cineraria, Azadirachta indica and Ailanthus excels are more beneficial under adverse environments due to their drought hardiness, resistance to inhospitable climate and assured economic returns. These tree species can be grown on soils having poor fertility, moisture deficit and high soil temperature. 2022-12-31T00:00:00+00:00 https://www.i-scholar.in/index.php/Rjst/article/view/219017 Solubility Study and Thermodynamic Analysis of Pimelic acid in water, Ethanol and their Binary mixture 2023-02-27T15:22:29+00:00 Sandip B. Nahire nahiresandip@rediffmail.com The focus of this work was on experimental measurements and numerical computations of Pimelic acid solubility in water, ethanol, and their binary combination. At temperatures ranging from (293.15 to 303.15) K, the solubility of Pimelic acid in pure solvents and their binary mixtures was evaluated using the equilibrium measurement method. To evaluate the data quality, the experimental results were correlated to the Apelblat equation. The Apelblat model's solubility correlations were in good accord with experimental data. 2022-12-31T00:00:00+00:00 https://www.i-scholar.in/index.php/Rjst/article/view/219018 New Trend of Doing Things with Technology Pertaining to Nursing “Technology modern trends that drive Healthcare” 2023-02-27T15:22:29+00:00 J. Emy Jancy Rani demynurse@gmail.com Nursing is dynamic by its own way and this dynamism give rise to various trends. Sound empirical knowledge is the base of nursing as in any other profession. This knowledge is the base for all the innovations which in turn evolve as trends in nursing. The trends in nursing education are the cornerstone for the dynamic nature of nursing profession. The article outlines various trends in nursing education with reference to India. Thus, the software can be seen as part of an abstract rationality, whereas how it is deployed by nurses is based on a practical rationality that places practice and experience first and sees the technology and protocols as tools. 2022-12-31T00:00:00+00:00 https://www.i-scholar.in/index.php/Rjst/article/view/219019 A Review on Quality control and Standardization of herbals 2023-02-27T15:22:29+00:00 Vaishnavi R. Warhade vaishnaviwarhade123@gmail.com Amol Dighe The medicinal plants are important source for pharmaceutical manufacturing. Medicinal plants &amp; herbal medicines account for a significant percentage of the pharmaceutical market. There is increasing awareness and general acceptability of the use of herbal drugs in today’s medical practice although most of these applications are not scientific. Herbal medicines are not a simple task since many factors influence the biological efficacy and Reproducible therapeutic effect. So it is necessary to improve safety of herbal drugs by developing certain quality control parameters and by following the WHO guidelines for herbal medicine WHO specific criteria for assessing the safety, efficacy, and quality of herbal medicines are critical for global harmonisation. The term “standardisation” refers to the assurance of a drug’s identification, quality, and purity at all stages of its life cycle. This study examines the need for and breadth of herbal medicine standardisation techniques for optimal quality assurance.To provide a platform for the quality control of traditional herbal medicines and to discover novel therapeutics composed of multiple chemical compounds, it is necessary to combine chemistry, pharmacology, medicine, and even statistics. 2022-12-31T00:00:00+00:00 https://www.i-scholar.in/index.php/Rjst/article/view/219021 Favipiravir: An Antiviral Drug 2023-02-27T15:22:29+00:00 Ganesh Bharskar ganeshb7748@gmail.com Pratik Malvade Favipiravir is an antiviral drug that has been shown to treat a variety of life-threatening infections, including Ebola, Lassa, and the COVID-19 virus. It's a pyrazine carboxamide derivative with antiviral action that targets RNA-dependent RNA polymerase enzymes, which are required for viral genome transcription and replication. Favipiravir is an antiviral previously indicated for influenza and Ebola, which has shown some promise in early trials for treatment of COVID-19. The nucleoside analogue favipiravir is rapidly metabolized in host cells which disrupts viral synthesis and leads to mutagenesis The mechanism of action of the Favipiravir and Side effects like QTc prolongation or teratogenicity pose risk to extensive community application discusses in this review. In this article, we have tried to provide a comprehensive, evidence-based review of this drug about synthesis, Pharmacology, Mechanism of Action, Antiviral activity, Consequences. 2022-12-31T00:00:00+00:00 https://www.i-scholar.in/index.php/Rjst/article/view/219023 A Review on Phytochemical Investigation of <i>Gymnema sylvestre</i> Leaves 2023-02-27T15:22:29+00:00 Sejal M. Karwa sejalkarwa18@gmail.com Dattaprasad N. Vikhe Ravindra S. Jadhav <em>Gymnema sylvestre</em> is a plant included in Apocynaceae family and is located in many regions of Asia, Africa and Australia. It is known to have blood glucose lowering potential and, thus, is widely used in traditional and Ayurvedic systems of medicine. A scrutiny of literature revealed some notable pharmacological activities of the plant such as antidiabetic, antiobesity, hypolipidaemic, antimicrobial, free radical scavenging and anti-inflammatory. The phytoconstituents responsible for sweet suppression activity includes triterpene saponins known as gymnemic acids, gymnemasaponins, and a polypeptide, gurmarin. Efforts have been made to prepare gudmar dried extract. These extracts were subjected for preliminary qualitative analysis, quantitative estimation of terpenoides, alkaloids and various other compounds. The present review is an attempt to highlight the phytochemical screening as well as its extraction process. Also chromatographic studies gave the presence of different compounds which can be used in creating monograph for this species. 2022-12-31T00:00:00+00:00