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Kagathara, Virendra G.
- Evaluation of Antiulcer Activity of Piper betel Leaves Extract in Rats
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Authors
Neeraj S. Vyawahare
1,
Virendra G. Kagathara
2,
R. G. Katedeshmukh
3,
Pushpendra K. Sharma
1,
Smeeta M. Mohod
4
Affiliations
1 Department of Pharmacology, AISSMS College of Pharmacy, Kennedy Road, Near RTO, Pune-411001, Maharashtra, IN
2 Department of Pharmacology, Faculty of Pharmacy, Dharamsinh Desai University, College Road, Nadia-387001, Gujarat, IN
3 Indira College of Pharmacy, Pune, Maharashtra, IN
4 Poona College of Pharmacy & Research Centre, Pune, IN
1 Department of Pharmacology, AISSMS College of Pharmacy, Kennedy Road, Near RTO, Pune-411001, Maharashtra, IN
2 Department of Pharmacology, Faculty of Pharmacy, Dharamsinh Desai University, College Road, Nadia-387001, Gujarat, IN
3 Indira College of Pharmacy, Pune, Maharashtra, IN
4 Poona College of Pharmacy & Research Centre, Pune, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 2, No 4 (2010), Pagination: 278-282Abstract
In Indian traditional system of medicine, the leaves of Piper betel are recommended for the management of peptic ulcer. In light of this, the antiulcer activity of hydroalcoholic extract of Piper betel (HEPB) leaves was evaluated in rats employing the HCl-ethanol, acute stress and pylorus ligation models to induce the experimental gastric ulcers. Pretreatment with Piper betel extract provided significant ulcer protective effect in all the experimental models along with significant increase in gastric pH and decrease in gastric fluid volume. Thus, it can be concluded that hydroalcoholic extract of Piper betel leaves possesses antiulcer activity which can be attributed to its putative mechanism of action.Keywords
Acute Stress, Antiulcer Activity, HCl-Ethanol, Piper Betel, Pylorus Ligation.References
- Govindrajan R, Vijayakumar M, Singh M, Rao CV, Shirwaikar A, Rawat AKS, Pushpangadan P. Antiulcer and antimicrobial activity of Anogeissus latifolia. J Ethanopharmacol. 2006; 110(106):57-61.
- Umamaheshwari M, Asokkumar K, Rathidevi R, Sivashanmugam AT, Subhadradevi V, Ravi TK. Antiulcer and in vitro antioxidant activities of Jasminum grandiflorum L. J Ethnopharmacol. 2007; 464-70.
- Toma W, Hirumaluma CA, Guerrero RO, Souza-Brito ARM. Preliminary studies of Mammeam americana L. (Guttiferae) bark/latex extract point to an effective antiulcer effect on gastric ulcer model in mice. Phytomedicine. 2005; 12:345-50.
- Bhattacharya S, Banerjee D, Bauri AK, Chattopadhyay S and Bandyopadhyay SK. Healing property of the Piper betel phenol phenol, allylpyrocatechol against indomethacin induced stomach ulceration and mechanism of action. World J Gastroenterol. 2007a; 13(27):3705-13.
- Grover JK, Vats V. Proton pump inhibitors. Trop Gastroentrol. 1999; 20:16-28.
- Miedrer SE. Will anti-ulcer drugs soon differ only in their side effects? Fortschr Med. 1986; 104:918-20.
- Akhtar MS, Akhtar AH, MA Khan. Antiulcrogenic effect of Ocimum basilicum extracts, volatile oil and flavonoids glycosides in albino rats. Int J harmacogn. 1992; 30:97-104.
- Chan FK, Leung WK. Peptic ulcer disease. Lancet. 2002; 360:933-41.
- Vyawahare NS, Deshmukh VV, Gadakari MR, Kagathara VG. Plants with antiulcer activity. Pharmacognosy review. 2009; 3(5):108-15.
- Borrelli F, Izzo AA. The plant kingdom as a source of anti-ulcer remedies. Phytother Res. 2000; 14:581-91.
- Bhattacharya S, Mula S, Gamre S, Kamat JP, Bandyopadhyay SK, Chattopadhyay S. Inhibitory property of Piper betel extract against photosensitization-induced damages to lipids and proteins. Food Chemistry. 2007b; 10(4):1474-80.
- Anonymus. The wealth of India (A dictionary of Indian raw materials and industrial products) Raw materials. New Delhi: Council of Scientific and Industrial Research. 1985; Vol-3.
- Chatterjee A, Pakrashi SC. Treatise of Indian Medicinal plants, Vol I, New Delhi, CSIR, 1995.
- Mujamdar B, Chaudhary S, Roy A, Bandyopadhyay SK. Effect of ethanol extract of Piper betel Linn leaf on healing of NSAID-induced experimental ulcer - a novel role of free radical seavenging action. Ind J Expt Biol 2003; 41:311-15.
- Arambewela LSR, Arawawala LDAM, Ratnasooriya WD. Antidiabetic activities of aqueous and ethanolic extracts of Piper betel leaves in rats. J Ethanopharmacol. 2005; 102:239-45.
- Vyawahare NS, Bodhankar SL. Neuropharmacological profile of Piper betel leaves extract in mice. Pharmacologyonline. 2007; 2:146-62.
- Mujamdar B, Chaudhary S, Roy A, Bandyopadhyay SK. Potential antiulcerogenic activity of ethanol extract of leaf of Piper betel Linn; by antioxidative mechanism. Int. J Clin Biochem. 2002; 17:49-57.
- Repetto MG, Llesuy SF. Antioxidant properties of neutral compounds used in popular medicine for gastric ulcers. Braz. J. Med. Biol. Res. 2002; 35: 523-34.
- Bafna PA, Balaraman R. Antiulcer and antioxidant activity of pepticare-a herbomineral formulation. Phytomedicine. 2005; 15: 264-70.
- Suzuki Y, Hayashi M, Ito M, Yamagami I. Antiulcer effects of 4'-(2-carboxyethyl) phenyl trans-4-aminomethyl cyclohexanecarboxylate hydrochloride (Cetraxate) on various experimental gastric ulcers in rats. The Japanese J Pharmacol. 1976; 26(4); 471-80.
- Yesilada E, Gurbutz L, Ergun E. Effect of Cistus laurifolius L. flower on gastric and duodenal lesions. J Ethnopharmacol. 1997; 55:201-11.
- Andreo MA, Balfesterous KVR, Hiruma Lima CA, Souza Brito ARM, Vilegas W. Effect of Mouriri pusa extracts on experimentally induced gastric lesions in rodents: Role of endogenous sulfhydryls compounds and nitric oxide in gastroprotection. J Ethanopharmacol. 2006; 107:431-41.
- Shay H, Komarov SA, Fels SE, Meraze D, Gruenstein M, Siplet H. A simple method for the uniform production of gastric ulceration in the rat. Gastroenterol. 1945; 5:43-61.
- Piper DW, Stiel DD. Pathogenesis of chronic peptic ulcer, current thinking and clinical implications. Med Prog. 1986; 2:7-10.
- Szabo S. Mechanisms of mucosal injury in the stomach and duodenum: Time sequence analysis of morphologic, functional, biochemical and histochemical studies. Scan. J. Gastroent. 1987; 22 (127):21-8.
- Oates PJ, Hakkines JP. Studies on the mechanism of ethanolinduced gastrid damage in rats. Gastroenter. 1988; 94:10-21.
- Malairajan P, Gopalakrishnan G, narasimhan S, Jessi Kala Veni K, Kavimani S. Anti-ulcer activity of crude alcoholic extract of Toona ciliate Roemer (heart wood). J Ethnopharmacol. 2007; 110:348-51.
- Cho CH, Ogle CW, Dai S. Acute gastric ulcer formation in response to electrical vagal stimulation in rats. European J Pharmacol 1976; 35:215-9.
- Cho CH and Ogle CW. Cholinergic mediated gastric mast cell degranulation with subsequent histamine H1 and H2 receptor activation in stress ulceration in rats. European J Pharmacol. 1979; 55:23-33.
- Hase T and Moss BJ. Microvascular change of gastric mucosa in development of stress ulcers in rats. Gastroenterol. 1973; 65:224-6.
- Rao ChV, Maiti RN, Goel RK. Effect of mild irritant on gastric mucosal offensive and defensive factors. Indian J Physiol Pharmacol. 1999; 44:185-91.
- Bagchi M, Milnes M, Williams C, Balmoori J, Ye X, Stohs S, Bagchi D. Acute and chronic stress induced oxidative gastrointestinal injury in rats, and the protective ability of a novel grape seed proanthocyanidin extract. Nutrition Research. 1999; 19:1189-99.
- Bandyopadhyay U, Das D, Bandyopadhyay D, Bhattacharya M, Benerjee RK. Role of reactive oxygen species in mercapto-methlimidazole-induced gastric acid secretion and stress induced gastric ulceration. Current Science. 1999; 76:55-63.
- Brodie DA. The mechanism of gastric hyperacidity produced by pylorus ligation in the rat. American J Digestion Disease. 1966; 11:231-41.
- Rastogi L, Patnaik GK, Dikshit M. Free radicals and antioxidant status following pylorus ligation induced gastric mucosal injury in rats. Pharmacological Research. 1998; 38:125-32.