Research Journal of Pharmacology and Pharmacodynamics

D. A. Helen Sheeba ¹, V. Gauthami Yadav ¹

Affiliations
1 Malla Reddy Institute of Pharmaceutical Sciences, Maisammaguda, Dullapally (Post via Hakimpet), Secunderabad - 500 014, IN

Abstract

Complex regional pain syndrome type I (CRPS type I)--formerly reflex sympathetic dystrophy (RSD)--causes chronic, poorly controllable pain, autonomic, sensorimotor disorders, and serious trophic alterations in the later stages. It develops in the distal extremities mostly after minimal trauma or surgical intervention and rarely spontaneously. The severity of symptoms is disproportionate to the causative event. The latest scientific findings show that the previously called reflex sympathetic dystrophy (RSD), which was supposed to be a result of a hyper-reactive autonomic nervous system, is a very complex syndrome that occurs on different integration levels of the nervous system. The International Association for the Study of Pain (ISAP) introduced the more descriptive term "complex regional pain syndrome" (CRPS) in 1994. Possible role of peripheral inflammatory processes, abnormal sympathetic-afferent coupling and various other novel mechanisms of patho-physiology have led to various medications ,Physical therapy, occupational therapy, and psychotherapy which play an important role in the primary treatment of CRPS as non-invasive procedures.

Keywords

Complex Regional Pain Syndrome, Neuropathic Pain, Reflex Sympathetic Dystrophy, Causalgia Treatment Advances, Peripheral Nervous System.

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