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Mahadeva Rao, U. S.
- Ameliorative Role of Threshold Level of Bilirubin in Newborn Jaundice and Efficacy of Noni Fruit Extract on Phenyl Hydrazine Induced Jaundice Rat
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Authors
Affiliations
1 Department of Bio-Chemistry, S.R.M. Arts and Science College, Kattankulathur-603203, IN
2 Department of Biochemistry, University of Madras, Guindy Campus, Chennai-600 025, IN
1 Department of Bio-Chemistry, S.R.M. Arts and Science College, Kattankulathur-603203, IN
2 Department of Biochemistry, University of Madras, Guindy Campus, Chennai-600 025, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 3, No 4 (2011), Pagination: 196-201Abstract
The aims of the present work were to elucidate the role of bilirubin as a free radical scavenger in unconjugated hyperbilirubinemic newborns. Bilirubin above an optimum level is toxic to human systems and is extcreted in urinary and through gastrointestinal tract. It is observed that serum bilirubin up to 85μ mole/l (5mg/dl) has a free radical scavenger activity and exceeding 200μmole/l (12mg/dl) is highly pro-oxidant. Phototherapy is the accepted therapeutic management of jaundiced newborns and has been shown to augment the oxidative stress. The ethanolic extract of Noni fruit administered orally at a dose of 3mg/ml is found to diminish the oxidative stress in erythrocytes of phenylhydrazine–induced unconjugated hyperbilirubinemic jaundiced rats, treated with phototherapy, which ultimately reduces the bilirubin level without inducing additional damages.Keywords
Bilirubin, Free Radical Scavenger, Pro-Oxidant, Phototherapy, Jaundice, Oxidative Stress, Noni.
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- Screening of Phytochemicals and Antibacterial Activity of Marine Red Alga Portieria hornemannii (Lyngbye) P. C. Silva
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Authors
Affiliations
1 Division of Algal Biotechnology and Bionano Technology, Post Graduate and Research Department of Botany, Pachaiyappa’s College, Chennai – 600 030, IN
2 School of Basic Medical Sciences, Faculty of Medicine, University Sultan Zainal Abidin, Jalan Sultan Mahmud, 20400, Kuala Terengganu, Terengganu, MY
3 Department of Chemistry, Pachaiyappa’s College, Chennai – 600 030, IN
1 Division of Algal Biotechnology and Bionano Technology, Post Graduate and Research Department of Botany, Pachaiyappa’s College, Chennai – 600 030, IN
2 School of Basic Medical Sciences, Faculty of Medicine, University Sultan Zainal Abidin, Jalan Sultan Mahmud, 20400, Kuala Terengganu, Terengganu, MY
3 Department of Chemistry, Pachaiyappa’s College, Chennai – 600 030, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 9, No 3 (2017), Pagination: 131-136Abstract
The evaluation of phytochemicals and antimicrobial activities of marine red alga Portieria hornemannii against bacterial pathogens have been established in the present investigation. The quantitative phytochemical screening of the methanol extract of P. hornemannii, showed a maximum number of natural products such as tannins, flavonoids, glycosides, phenols, saponins, terpenoids, etc. The antimicrobial activity of methanol extract of P. hornemannii showed the highest inhibition against Staphylococcus aureus (77.77%) and the chloroform extract showed the lowest activity against Pseudomonas aeruginosa by showing (52.63%) as evaluated by disc diffusion method. Our findings provide the evidence that the methanol extract of P. hornemannii possesses the good antimicrobial activity and hence, the alga proves to be an effective therapeutic agent.Keywords
Phytochemical, Portieria hornemannii, Antibacterial Activity, Therapeutic Agent.References
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