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Rao, U. S. Mahadeva
- Amelioration of Gastric Lesions by Avocado (Persea americana) Fruit Extract on Indomethacin as well as Ethanol Induced Ulcerated Experimental Rats
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Authors
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1 Department of Chemistry, Mizan-Tepi University, P. O. No 121, Tepi, East Africa, ET
1 Department of Chemistry, Mizan-Tepi University, P. O. No 121, Tepi, East Africa, ET
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 2, No 4 (2010), Pagination: 303-308Abstract
In the present study, anti-ulcerogenic potential of Avocado fruit extract was evaluated using two different models of gastric lesions induced in experimental rats; 1) Indomethacin-induced gastric lesions and 2) Ethanol-induced gastric lesions. Pretreatment with oral administration of the extract of Avocado fruit extract (300 mg/kg) prevented the formation of acute gastric lesion induced by both the experimental models: further, treatment with the ethanolic extract of Avocado fruit extract for a period of 15 days significantly reduced the ulcer index, ulcerated surface and significantly elevated the levels of glycoprotein contents in gastric juice.Keywords
Avocado, Anti-Ulcerogenic Effect, Indomethacin-Induced Gastric Lesion, Ethanol-Induced Gastric Lesion, Ulcer Index.References
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- Elevated Singlet Oxygen Dependent Tissue Injury as well as Diminished Activity of Antioxidative Defense Mechanism by Sodium Valproate Clinical Course in Epileptic Children
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Authors
Affiliations
1 PG Department of Biochemistry, SRM College of Arts and Science, Chennai-603 203, IN
2 Faculty of Medicine and Health Science, Universititi Sultan Zainal Abidin, 20400 Kuala Terengganu, Terengganu, MY
1 PG Department of Biochemistry, SRM College of Arts and Science, Chennai-603 203, IN
2 Faculty of Medicine and Health Science, Universititi Sultan Zainal Abidin, 20400 Kuala Terengganu, Terengganu, MY
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 3, No 6 (2011), Pagination: 307-310Abstract
The study was aimed to determine the biochemical changes in the free radical profile and antioxidant enzyme status in epileptic children before and after treatment with VPA monotherapy. Methods: We have studied the levels of serum LPO (MDA), erythrocyte antioxidants (GSH, GPx, SOD and CAT) in 25 epileptic children before and after treatment with sodium valproate and compared them against 25 healthy children. Results: The results showed that MDA levels were increased (p<0.001) in epileptic children under VPA treatment compared to the controls. Antioxidant enzymes GPx, SOD, CAT activities were decreased (p<0.001) in epileptic children receiving VPA monotherapy whereas no significant changes when compared between before and after treatment with VPA. The level of GSH was also decreased (p<0.001) in follow-up cases of epileptic children receiving VPA therapy. Conclusion: It was hypothesized that the oxidants-antioxidants balance were modified further by sodium valproate in epileptic children.Keywords
Sodium Valproate, Antioxidants, Lipid Peroxidation, Oxidative Stress, Epilepsy, Free Radical.References
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