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Patil, Swati
- Antibacterial and Anti-Diarrhoel Activities of Flowers of Punica granatum Linn
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Authors
Affiliations
1 Department of Pharmacognosy and Phytochemistry, K M Kundnani College of Pharmacy, Cuffe parade, Mumbai-400 005, IN
2 K M Kundnani College of Pharmacy, Cuffe parade, Mumbai, IN
3 Orchid Research Laboratories Ltd. Chennai, IN
1 Department of Pharmacognosy and Phytochemistry, K M Kundnani College of Pharmacy, Cuffe parade, Mumbai-400 005, IN
2 K M Kundnani College of Pharmacy, Cuffe parade, Mumbai, IN
3 Orchid Research Laboratories Ltd. Chennai, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 1, No 2 (2009), Pagination: 87-89Abstract
Different extracts of Punica granatum flowers (Variety: Gulnar) were tested for antibacterial and anti-diarrhoeal activities. All the extracts showed good antibacterial activity which was comparable to that of cold water extract of Punica granatum fruit rind. Cold extracts showed better anti-diarrhoeal activity than soxhlet extracts in castor oil induced diarrhoea in rats as a model. Their anti-diarrhoeal activity was comparable to that of loperamide hydrochloride.Keywords
Punica Granatum, Antibacterial Activity, Anti-Diarrhoeal Activity.
References
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- Balows A. manual of Clinical Microbiology, American Society for Microbiology, Washington DC, 5th ed. 1991: pp. 1105-1116.
- Rawlins EA. Bentley's Textbook of Pharmaceutics, Bailliere Tindall, London, 8th ed.1977: pp. 515-516.
- Hugo W B and Russell A D. Pharmaceutical Microbiology, Blackwell Scientific Publications, 5th ed.1992:pp. 274.
- Subhash CM and Ashok Kumar C K. Studies on antidiarrhoeal activity of Ficus hispida. Leaf extract in rats. Fitoterapia. Volume 73, Issues 7-8, 2002;73(8): 663-667.
- Seth G S. Techniques in Pharmacology, Pharmatech-96 Manual, Department of Pharmacology, Medical college and K. E. M. Hospital, Mumbai, 1996: pp.36-38.
- Gricilda SF and Molly Thomas. Study of anti diarrhoeal activity of four medicinal plants in castor-oil induced diarrhoea. J of Ethnopharm.2001;71:73-76.
- Shidore PP, Mujumdar SM, Shrotri DS, Mujumdar AM. Anti-Diarrheal and Anti-Inflammatory Activity of Nutmeg Myristica-Fragrans Extracts. Ind J of Pharm Sci. 1985; 47:188.
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- Screening For Wound Healing Activity of Alcoholic Extract of Ocimum kilimandscharicum Leaves
Abstract Views :300 |
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Authors
Affiliations
1 K.L.E.S's College of Pharmacy, Ankola - 581314, Karnataka, IN
2 KM Kundnani College of Pharmacy, Cuffe Parade, Mumbai, IN
1 K.L.E.S's College of Pharmacy, Ankola - 581314, Karnataka, IN
2 KM Kundnani College of Pharmacy, Cuffe Parade, Mumbai, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 1, No 2 (2009), Pagination: 93-96Abstract
Objective: To investigate and rationalize the effects of Ocimum kilimandscharicumleaves(Lamiaceae) for their wound healing activity and probable mechanism underlying its protective effects in albino wistar rats.
Methods: The wound healing activity was evaluated using three different types of wound models viz; the excision, incision and dead space wound model. A supportive study was also made on granuloma tissue to estimate the level of hydroxy proline. The healing tissues obtained on the 11th post wounding day of the incision wound model were processed for histological study.
Results: The animals receiving the alcoholic extract of Ocimum kilimandscharicumleaves has shown to possess significant increase in wound closure rate, skin breaking strength, granuloma breaking strength, hydroxy proline content, granuloma dry weight and decrease in mean scar area.
Conclusion: The prohealing potential of the Ocimum kilimandscharicum leaves extract may probably be as a result of the presence of a mixture of phytoconstituents including flavonoids, steroids, etc. and increased collagen deposition as well as better alignment and maturation.
Keywords
Ocimum Kilimandscharicum, Alcoholic Extract, Wound Healing, Hydroxy Proline, Phytochemicals.References
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- Puratchikody A, Nithya Devi C, Nagalakshmi G. Wound healing activity of Cyperus rotundus Linn. Indian J Pharm Sci. 2006; 68(1): 97-101.
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- Manjunath BK, Vidya M, Krishna V, Mankani KL. Wound healing activity of Leucas Hirta. Ind J Pharm Sci. 2006; 5: 380-84.
- Manjunatha KP, Kulkarni GT, Patil GS. Preliminary phytochemical investigation and wound healing activity of the ischolar_mains of Swertia chirata buch. Ham(Gentinaceae). Indian drugs. 2006; 43:535-37.
- Effect of Acacia catechu and Rotula aquatica on the DNA: Implications for Cancer Therapy
Abstract Views :356 |
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Authors
Affiliations
1 Department of Pharmacognosy and Phytochemistry, Principal K M Kundnani College of Pharmacy, Cuffe Parade, Mumbai-400 005, IN
2 Principal, Singhgad's Institute of Pharmaceutical Sciences, Kusgaon (BK), Lonavala, IN
3 Department of Genetics, BARC, Mumbai, IN
4 Orchid Research Laboratories Ltd. 476, Chennai 600119, IN
1 Department of Pharmacognosy and Phytochemistry, Principal K M Kundnani College of Pharmacy, Cuffe Parade, Mumbai-400 005, IN
2 Principal, Singhgad's Institute of Pharmaceutical Sciences, Kusgaon (BK), Lonavala, IN
3 Department of Genetics, BARC, Mumbai, IN
4 Orchid Research Laboratories Ltd. 476, Chennai 600119, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 1, No 1 (2009), Pagination: 31-34Abstract
Ethnobotanical search has revealed the use of water extracts of bark of Acacia catechu and Rotula aquatica in the treatment of cancer. The aqueous extracts of both above mentioned plants were evaluated for antimitotic activity using the meristamatic cells of Allium cepa ischolar_mains. The results showed inhibition of prophase stages in cell division. The A.catechu and R. aquatica treated ischolar_mains of A.cepa were treated with tritiated thymidine. DNA was extracted from these ischolar_main tips. The total DNA was then counted in a scintillation counter. The results were compared with a positive control Methotrexate, a known anticancer drug. Roots treated with Plain water were used as negative control. The total DNA count from the treated ischolar_mains and that from Methotrexate treated ischolar_mains was less than that of Plain water. The extracted DNA was subjected to gel electrophoresis. DNA from ischolar_mains treated with extracts and from Methotrexate treated ischolar_mains showed fragmentation where as that from the Plain water was intact.Keywords
Acacia catechu, Rotula aquatica, Allium cepa, Antimitotic Activity, DNA Isolation.References
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- Abhang RY, Joglekar PP, Kulkarni P H. Preliminary study on the effect of T. Cordifolia on mitosis. Ancient Science. 1991; 1 and 2:7-8.
- Yang CS, Lee M J, Chen L. Human salivary tea catechin levels and catechin esterase activities: implication in human cancer prevention studies, Cancer Epidemiol Biomarkers Prev. 1999; 8(1): 83-89.
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- Lehninger LA, Nelson A. Principles of Biochemistry, CBS Publishers and Distributors, Delhi, 1993; pp.725 - 818,
- Freifelder D. Molecular Biology, Jones and Bartlett Publishers Inc., Boston, 2nd ed: pp.123-133
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- Micklos DA, Freyer GA. DNA Science. J Cell Sci. 1974;15(3): 264-267.
- Formulation and Evaluation of Curcuma longa and Azadirachta indica Extracts as Vaginal Contraceptive
Abstract Views :281 |
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Authors
Affiliations
1 Sinhgad Institute of Pharmaceutical Sciences, Kusgaon (BK), Lonavala Pune-410401, IN
2 Prin. K.M. Kundnani College of Pharmacy, Mumbai-400005, IN
1 Sinhgad Institute of Pharmaceutical Sciences, Kusgaon (BK), Lonavala Pune-410401, IN
2 Prin. K.M. Kundnani College of Pharmacy, Mumbai-400005, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 4, No 1 (2012), Pagination: 21-24Abstract
It was noticed that, no safe and reversible chemical agent is known that can adequately control fertility without producing toxic effect. Herbal drugs, the natural alternatives for chemical drugs are defined as the art and science of restoring a sufferer to health by the use of plant remedies. Herbs have long held an important place in the treatment of ailments and herbal medicines are still popular. Herbal medicines are being used by about 80% of the world population primarily in the developing countries for primary health care. They have stood the test of time for their safety, efficacy, cultural acceptability and lesser side effects.In view of above discussion, it is planned to evaluate the extracts of two indigenous plants for spermicidal activity and to develop formulation as vaginal contraceptives.
In the present study the ethanolic extracts of Curcuma longa rhizomes (30μg/ml) and Azadirachta indica leaves (1mg/ml) were alone treated with human semen sample (containing 1million sperm/ml). Both the extract showed dose dependent spermicidal action. The ethanolic extracts of Curcuma longa and Azadirachta indica were alone formulated in two different vaginal gel using Carbapol (1%) and at dose of 10μl evaluated for contact spermicidal activity. Both the vaginal gel was further evaluated for viscosity, spreadability, and mucoadhesive test and stability studies.
The formulation showed significant reduction in sperm motility. Stability studies indicate that formulation is stable at temperature 25°C and 35°C.
It was therefore concluded that the vaginal gel containing Curcuma longa and vaginal gel containing Azadirachta indica extracts may have a wide potential to be used as a vaginal contraceptive agent.
Keywords
Population, Spermicidal, Sperm Count, Vaginal Contraceptives.References
- Mishra R., Singh S., Reversible antifertility effect of aqueous rhizome extract of Curcuma longa in male laboratory mice, Contraception, 79, 2009, 479-487.
- Tara R., Manoj M., Mahadevan R., Curcumin a potential vaginal contraceptive Contraception, 68, 2003, 219-223.
- Khillare B., Shrivastav T., Spermicidal activity of Azadirachta indica (neem) leaf extract, Contraception, 68, 2003, 225-229.
- Mishra R., Sing K., Effect of aqueous Extract of Azadirachta indica on reproductive on reproductive organs in male mice, Indian Journal of Experimental Biology, 43, 2005, 1093-1103.
- Trease, Evans, Aspects of Asian Medicine and its Practice in the West, Pharmacognosy, W.B. Saunders, London, 15, 2002, 470.
- Kour L., Garg R., Gupta G., Topical Gels: A Review, Research Journal of Pharmacy and Technology 3, 2010, 17-24.
- Lee C., In Vitro Spermicidal Tests, Contraception 54, 1996, 131-147.
- Glycine max: The Antioxidant and Anti-Hyperlipidemic Nutraceutical
Abstract Views :489 |
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Authors
Manasi Nabar
1,
Swati Patil
2
Affiliations
1 Prin. K M Kundnani College of Pharmacy, 23, Jote Joy Bldg., Rambhau Salgaonkar Marg, Cuffe Parade, Mumbai-400005
2 Prin. K M Kundnani College of Pharmacy, 23, Jote Joy Bldg., Rambhau Salgaonkar Marg, Cuffe Parade, Mumbai-400005, IN
1 Prin. K M Kundnani College of Pharmacy, 23, Jote Joy Bldg., Rambhau Salgaonkar Marg, Cuffe Parade, Mumbai-400005
2 Prin. K M Kundnani College of Pharmacy, 23, Jote Joy Bldg., Rambhau Salgaonkar Marg, Cuffe Parade, Mumbai-400005, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 2, No 5 (2010), Pagination: 328-331Abstract
The nutraceutical industry has seen a great boom in the recent years as a result of the consumers seeking the convenient "healthful" solution in their diet. Amongst the various candidates of the nutraceutical world the everyday soybean has become a great nutraceutical today. In view of the importance gained by soybeans (Glycine max Family: Leguminosae) studies were carried out on the seeds of soybean. To evaluate its nutraceutical claims, antioxidant and anti-hyperlipidemic evaluations were carried out on the extracts obtained from the seeds of Glycine max. With an increase in the health reports relating free radicals and high lipid levels to an array of disease conditions, there has been a search for a safer solution from the nutraceutical world as a support to the conventional therapy. In the current study, the free radical scavenging activity was carried out using the DPPH method whereas the diet induced hyperlipidemia model in hamsters was used to evaluate the antihyperlipidemic activity. Both the studies yield results that support the current position of soybeans in the nutraceutical world.Keywords
Glycine max, Soybean, Antioxidant, Anti-Hyperlipidemic.References
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