Refine your search
Collections
Year
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Nanda, Smiti
- Comparative Study of Nifedipine and Terbutaline as Tocolytic Agents in the Management of Preterm Labour
Abstract Views :585 |
PDF Views:2
Authors
Affiliations
1 General Hospital, Rohtak, Haryana, IN
2 PGIMS, Rohtak, Haryana, IN
3 SDM College of Pharmacy, Kaithal, Haryana, IN
1 General Hospital, Rohtak, Haryana, IN
2 PGIMS, Rohtak, Haryana, IN
3 SDM College of Pharmacy, Kaithal, Haryana, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 5, No 4 (2013), Pagination: 232-236Abstract
The aim of this study was to compare the effectiveness, safety and possible adverse effects of terbutaline and nifedipine in prolonging pregnancy beyond 48 hrs. A randomized controlled trial was conducted with 60 pregnant women admitted with preterm labor, randomized into two groups, which were given terbutaline (30 patients) and nifedipine (30 patients) respectively. Bivariate and multivariate analysis, using regression, were used to analyze the data. No statistically significant difference was found between the two groups in terms of prolongation of gestation to 48 hrs. Both the drugs significantly prolonged the pregnancy (P < 0.001), however there was no statistically significant (P > 0.05) difference in the tocolytic efficacy (mean absolute prolongation of gestation) and birth outcomes between the two groups. The maximum number of patients in both groups (47 % in group A and 70 % in group B) delivered between 34.1 to 37 weeks. However, side effects were significantly more common in the terbutaline group (P < 0.02), especially maternal tachycardia, transient hypotension and chest pain. In the terbutaline group, 14.8 % neonates required mechanical ventilation while 11.1 % suffered intra ventricular hemorrhage. Terbutaline and nifedipine appeared to be equally effective in their tocolytic action. However, nifedipine did have the advantage of the ease of administration. It also had significantly less side effects.Keywords
Terbutaline, Nifedipine, Preterm Labor and TocolysisReferences
- Report of the consensus development-conference on the effect of corticosteroids for fetal maturation on perinatal outcomes. Washington: National Institute of Health; NIH publication. 95; 1994: 3784-3786.
- Darey BC, Clark AL, Kernek K, Joseph A and Spinnato MD. Maintenance of oral nifedipine for preterm labor: a randomized clinical trial. American Journal of Obstetrics and Gynecology. 181 (4); 1999: 822-827.
- Neonatal morbidity and mortality: report of the national neonatal, perinatal database. Indian Pediatrics. 34; 1997: 1039- 1042.
- Tsatsaris V, Papatsonis, Goffinet F, Dekker G and Carbonne B. Tocolysis with nifedipine or betaadrenergic agonist.: a meta analysis. Obstetrics and Gynecology. 97; 2001: 840-847.
- Cartis SN, Toig G, Heddinger LA and Ashmead G. A double blind study comparing ritodrine and terbutaline in the treatment of preterm labor. American Journal of Obstetrics and Gynecology. 150; 1984: 7-14.
- Nanda K, Cook LA, Gallo MF and Grimes DA. Terbutaline pump maintenance therapy after threatened preterm labor for preventing preterm birth. Cochrane Database of Systematic Reviews. 4; 2002: CD003933.
- Guinn DA, Goepfert AR, Owen J, Wenstrom KD and Hauth JC. Terbutaline pump maintenance therapy for prevention of preterm delivery: a double blind trial. American Journal of Obstetrics and Gynecology. 179; 1998: 874-878.
- Read MD and Wellby DE. The use of a calcium antagonist (nifedipine) to suppress preterm labor. British Journal of Obstetrics and Gynecology. 93; 1986: 933-937.
- Ferguson JE, Dyson DC, Schutz T and Stevenson DK. A comparison of tocolysis with nifedipine or ritodrine: analysis of efficacy and maternal, fetal and neonatal outcome. American Journal of Obstetrics and Gynecology.163; 1990: 105-111.
- Garcia Velasco JA and Gonzalez GA. A prospective randomized trial of nifedipine versus ritodrine in threatened preterm labor. International Journal of Gynecology and Obstetrics. 61; 1998: 239-244.
- Rayamajhi R and Pratap K. A comparative study between nifedipine and isoxsuprine in the suppression of preterm labor. Kathmandu University Medical Journal. 1 (2); 2003: 85-90.
- Wallace RL, Caldwell DL, Ansbacher R and Olterson WN. Inhibition of premature labor by terbutaline. American Journal of Obstetrics and Gynecology. 57 (4); 1978: 387-392.
- American College of Obstetricians and Gynecologists. Assessment of risk factors for preterm birth. ACOG Practice Bulletin No. 31. Obstetrics and Gynecology. 98; 2001: 709- 716.
- Gromme LJ, Goldenberg RL and Oliver SP. Neonatal periventricular-interventricular hemorrhage after maternal betasympathomimetic tocolysis. American Journal of Obstetrics and Gynecology. 167; 1992: 873-875.
- Smith CS and Woodland MB. Clinical comparison of oral nifedipine and subcutaneous terbutaline for initial tocolysis. American Journal of Perinatology. 10; 1993: 280-284.
- Papatsonis DNM,Van HP and Ader HJ. Nifedipine and ritodrine in the management of preterm labor. A randomized multicenter trial. Obstetrics and Gynecology. 90 (2); 1997: 230-234.
- Weerakul W, Chettachdroen A and Sulhutvoravul S. Nifedipine versus terbutaline in management of preterm labor. International Journal of Obstetrics and Gynecology. 76; 2002: 311-313.
- Hearne EA and Nagey D. Therapeutic agents in preterm labor: tocolytic agents. Clinical Obstetrics and Gynecology. 43 (4); 2002: 787-801.