Research Journal of Pharmacology and Pharmacodynamics

Shoaib Ahmad ¹

Affiliations
1 University School of Pharmaceutical Sciences, Rayat-Bahra University, Mohali-140104, IN

Abstract

Nerium oleander is a member of plant family Apocynaceae. Almost all of its parts contain cardioactive glycoside oleandrin with anticancer activity. Oleandrin has been subjected to numerous pharmacological studies. Pharmacological effects of oleandrin and other established cardiac glycosides (viz. g-strophanthin, digoxin and digitoxin) have been compared in several studies. Oleandrin primarily produces characteristic effects through Na+,K+-ATPase. Oleandrin is used to treat myocardial insufficiency. Oleander and oleandrin cause toxicity because of the action on cardiovascular tissues. Oleandrin can be used for anticancer therapy for cancerous celltargeting. The present article is an attempt to outline the historical developments in the area of cardiovascular pharmacology of oleandrin.

Keywords

Nerium Oleander, Oleander, Oleandrin, Heart, Na+K+-ATPase.

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Shoaib Ahmad ¹

Affiliations
1 University School of Pharmaceutical Sciences, Rayat-Bahra University, Mohali-140104, IN

Abstract

Mild to severe sore throat is often associated withe pharyngitis. Lozenges are a traditional treatment of sore throat and reduce discomfort caused by oral inflammation. Amylmetacresol and dichloro-benzylalcohol are topical antiseptics popular Strepsils lozenges. Antibiotics are not recommended for treating sore throat which can be managed by use of local anesthetics as well as topical antiseptics. Present article is an attempt to review the developments in new approach for managing sore throat in clinical conditions.

Keywords

Sore Throat, Pharyngitis, Lozenges, Strepsils, Amylmetacresol.

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