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Ali, Sadath
- Effect of Allium sativum in Immoblilization Stress Induced Albino Rats
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Authors
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1 Department of Pharmacy, Singhania University, Rajasthan, IN
2 Luqman College of Pharmacy, Gulbarga, Karnataka, IN
1 Department of Pharmacy, Singhania University, Rajasthan, IN
2 Luqman College of Pharmacy, Gulbarga, Karnataka, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 2, No 4 (2010), Pagination: 293-295Abstract
The present study was carried out to evaluate the effect of ethanolic extract of Allium sativum (Alliceae) on immobilization stress induced albino rats. The effect was assessed by estimation of various biochemical parameters like glucose, cholesterol, triglycerides and blood urea nitrogen (BUN), and by determining the weight of organ such as, liver, spleen, testes, adrenal gland, blood cell count (WBC) and also the differential count at a dose of 200 mg/kg body weight per oral. The extract showed significant (p<0.001) decrease in blood glucose, cholesterol, triglyceride and BUN and also decreased the weight of organs. It also showed a significant (p<0.05) decrease in weight of adrenal gland. A significant (p<0.01) decrease in WBC count, polymorphs and monocytes and decrease in lymphocytes (p<0.05) and eosinophils was observed, compared to control group. Thus the obtained results revealed that the Allium sativum has got a significant anti stress activity.Keywords
Immobilization Stress, Allium sativum, Cortisol, WBC, BUN.
References
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- To Study the Effect of Allium Sativum on Various Biochemical Parameters on Stress Induced in Albino Rats
Abstract Views :320 |
PDF Views:0
Authors
Affiliations
1 Luqman College of Pharmacy, Gulbarga, Karnataka, IN
1 Luqman College of Pharmacy, Gulbarga, Karnataka, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 2, No 5 (2010), Pagination: 335-339Abstract
The present study was carried out to evaluate the effect of ethanolic extract of Allium sativum on swimming endurance test and cold stress in albino rats. The effect was assessed by swimming survival time, estimation of various biochemical parameters like glucose, cholesterol, triglycerides, cortisol and blood urea nitrogen (BUN). Blood cell count (WBC) and also the differential count was measured. In cold stress ulcer index , PH of gastric juice and weight of organ such as liver, spleen, testes, adrenal gland at a dose of and 200 mg/kg body weight per oral was determined. It was found that extract significantly (p<0.001) increases swimming time. Showed significant (p<0.001) decrease in blood glucose, cholesterol, triglyceride, cortisol and BUN. A significant (p<0.01) decrease in WBC count, polymorphs, monocytes, lymphocytes and eosinophils in swimming endurance test. In cold stress significant (p<0.01) decrease in weight of organs, significant (p<0.001) decrease in ulcer index and increase PH of gastric juice was observed compared to control group. Thus the obtained results revealed that the Allium sativum has got a significant anti-stress activity.Keywords
Swimming, Cold Stress, Allium sativum, WBC, BUN.References
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- Sabry M Shaarawy, Amany A Tohamy, Saad M. Elgendy, Zakaria Y Abd Elmageed, Abeer Bahnasy, Maha S Mohamed, Emad Kandil, and Khalid Matrougui. Protective Effects of Garlic and Silymarin on NDEA-Induced Rats Hepatotoxicity. Int J Biol Sci: 2009; 5(6): 549–557.
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