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Roshan, S.
- Effect of Allium sativum in Immoblilization Stress Induced Albino Rats
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Authors
Affiliations
1 Department of Pharmacy, Singhania University, Rajasthan, IN
2 Luqman College of Pharmacy, Gulbarga, Karnataka, IN
1 Department of Pharmacy, Singhania University, Rajasthan, IN
2 Luqman College of Pharmacy, Gulbarga, Karnataka, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 2, No 4 (2010), Pagination: 293-295Abstract
The present study was carried out to evaluate the effect of ethanolic extract of Allium sativum (Alliceae) on immobilization stress induced albino rats. The effect was assessed by estimation of various biochemical parameters like glucose, cholesterol, triglycerides and blood urea nitrogen (BUN), and by determining the weight of organ such as, liver, spleen, testes, adrenal gland, blood cell count (WBC) and also the differential count at a dose of 200 mg/kg body weight per oral. The extract showed significant (p<0.001) decrease in blood glucose, cholesterol, triglyceride and BUN and also decreased the weight of organs. It also showed a significant (p<0.05) decrease in weight of adrenal gland. A significant (p<0.01) decrease in WBC count, polymorphs and monocytes and decrease in lymphocytes (p<0.05) and eosinophils was observed, compared to control group. Thus the obtained results revealed that the Allium sativum has got a significant anti stress activity.Keywords
Immobilization Stress, Allium sativum, Cortisol, WBC, BUN.
References
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- To Study the Effect of Allium Sativum on Various Biochemical Parameters on Stress Induced in Albino Rats
Abstract Views :258 |
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Authors
Affiliations
1 Luqman College of Pharmacy, Gulbarga, Karnataka, IN
1 Luqman College of Pharmacy, Gulbarga, Karnataka, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 2, No 5 (2010), Pagination: 335-339Abstract
The present study was carried out to evaluate the effect of ethanolic extract of Allium sativum on swimming endurance test and cold stress in albino rats. The effect was assessed by swimming survival time, estimation of various biochemical parameters like glucose, cholesterol, triglycerides, cortisol and blood urea nitrogen (BUN). Blood cell count (WBC) and also the differential count was measured. In cold stress ulcer index , PH of gastric juice and weight of organ such as liver, spleen, testes, adrenal gland at a dose of and 200 mg/kg body weight per oral was determined. It was found that extract significantly (p<0.001) increases swimming time. Showed significant (p<0.001) decrease in blood glucose, cholesterol, triglyceride, cortisol and BUN. A significant (p<0.01) decrease in WBC count, polymorphs, monocytes, lymphocytes and eosinophils in swimming endurance test. In cold stress significant (p<0.01) decrease in weight of organs, significant (p<0.001) decrease in ulcer index and increase PH of gastric juice was observed compared to control group. Thus the obtained results revealed that the Allium sativum has got a significant anti-stress activity.Keywords
Swimming, Cold Stress, Allium sativum, WBC, BUN.References
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- Naga Raju, T. Rajani Kanth V, and. Lavanya K Effect of methanolic extract of Allium sativum (AS) in delaying cataract in STZ-induced diabetic rats. J Ocul Biol Dis Infor: 2008 March; 1:1: 46–54.
- Young-Min Lee, Oh-Cheon Gweon, Yeong-Ju Seo, Jieun Im, Min-Jung Kang, Myo-Jeong Kim, and Jung-In Kim Antioxidant effect of garlic and aged black garlic in animal model of type 2 diabetes mellitus .Nutr Res Pract:.2009; 3:2: 156–161.
- Sabry M Shaarawy, Amany A Tohamy, Saad M. Elgendy, Zakaria Y Abd Elmageed, Abeer Bahnasy, Maha S Mohamed, Emad Kandil, and Khalid Matrougui. Protective Effects of Garlic and Silymarin on NDEA-Induced Rats Hepatotoxicity. Int J Biol Sci: 2009; 5(6): 549–557.
- Takasugi N, Kotoo K, Fuwa A, Saito H. Effect of garlic on mice exposed to various stresses. Oyo Tukurl Pharmacometrics. 1984; 28: 991–1002.
- Durak I, Ozturk HS, Olcay E, Güven C. Effects of garlic extract supplementation on blood lipid and antioxidant parameters and atherosclerotic plaque formation process in cholesterol-fed rabbits. J Herb Pharmacother 2002: 2 :2: 19–32.
- Nimbekar, Patil and Patki. Pharmacological evaluation of antistress and androgenic activity of polyherbal formulatiom AP 30000 containing P Ginseng. Ind drugs.2001; 27-31.
- Bhargava KP, Singh N. Anti stress activity of Ocimum santium. Ind J Exper biology.1981;73:443-451.
- Nagaraja HS, Jeganathan PS. Forced Swimming stress induced alterations in ingestive behavior in rats. Ind j Physiol Pharmacol.2003; 41(1): 94-100
- Vinay Agarwal, Bhayesh Gupta, Ushan Singhal, SK Bajpal. Examination stress changes in serum cholesterol, triglycerides and total lipids. Ind J Physiol Pharmacol .1987;.41(1): 404-408.
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- A Review on Pharmacological Activities of Abutilon indicum (Atibala)
Abstract Views :263 |
PDF Views:2
Authors
T. Shekshavali
1,
S. Roshan
1
Affiliations
1 Mewar University, Rajasthan, IN
1 Mewar University, Rajasthan, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 8, No 4 (2016), Pagination: 171-174Abstract
The plant Abutilun indicum has wide range of medicinal and pharmacological applications. It is used in different traditional system of medicine and exhibits diuretic, hepatoprotiective, hypoglycemic, immuno modulatory, analgesic, antimicrobial, anti-malarial, wound healing and anti-diarrheal activities. Number of pharmacological studies have been conducted and wide range of biological activities have been observed such as anti-inflammatory, antihyperlipidemic This paper presents an overview on the pharmacological activities of different parts of this plant.Keywords
Hypoglycemic, Diuretic, Abutilon indicum, Bacillus pumilus, Famotidine.- Screening of Diuretic Activity of Traditionally used Medicinal Plants
Abstract Views :580 |
PDF Views:0
Authors
T. Shekshavali
1,
S. Roshan
1
Affiliations
1 Mewar University, Rajasthan, IN
1 Mewar University, Rajasthan, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 9, No 4 (2017), Pagination: 178-180Abstract
The Diuretic activity of Abutilon indicum and Amaranthus spinusus was studied. The fractions of ethyl acetate, methanol showed significant increase in the urine elimination, while benzene fraction doesn’t show diuresis. All the groups were compare to control group, frusemide was used as reference standard drug in this screening activity. The phytochemical screening study showed the presence of flavonoids, saponins, terpenoids, and steroid content in both the plants extract. The diuretic effect in all the extract may be due to phytochemicals present in the fractions except benzene fraction of A. indicum.Keywords
Amaranthus spinusus , Expectorant, Ethyl Acetate, Traditional, Frusemide.References
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