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Research Journal of Pharmacology and Pharmacodynamics

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2022

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Pawar, S. P.

Depression: As a Risk Factor for Coronary Heart Disease

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Authors

Marathe Varsha S. ¹, Azam Z. Shaikh ¹, S. P. Pawar ¹, Ritik. S. Jain ¹

Affiliations
1 Department of Pharmacology, P.S.G.V.P.M’s College of Pharmacy, Shahada. Department of Pharmacology, Ahinsa Institute of Pharmacy, Dondaicha, IN

Source

Research Journal of Pharmacology and Pharmacodynamics, Vol 14, No 3 (2022), Pagination: 139-145

Abstract

We conducted a review to resolve whether there is relationship between depression and coronary heart disease or not. Depression is a mental health problem which is spread widely and most of physicians are well acquainted with this concept of depression. Diagnosis of depression disorder based on continuity of illness, etiology of illness and number of symptoms - all these discriminations should be reported during inspecting the link between depression and coronary heart disease. We review the mechanism of linking depression and coronary heart disease i.e. relationship between depression and inflammation, depression and autonomic dysfunction, CHD and autonomic dysfunction, depression and Sleep architecture disruption, depression and circadian rhythm disruption, CHD and circadian rhythm disruption, and depression and behavioral mechanism. There is bidirectional association between depression and coronary artery disease i.e. coronary artery disease can cause major depressive disorder and depression is risk factor for CAD and its complications. Major depression is a devastating comorbid disease that can make recovery difficult and increase risk of cardiac mortality and morbidity. We also go over the therapy options like Psychotherapy, Electroconvulsive therapy, Exercise etc. But there are some antidepressant medications also available for treating depression in patients associated with CAD. The antidepressant medications like SSRIs e.g. Sertraline, fluoxetine, citalopram etc. appears to be safe in individual with depression and concomitant CAD or unstable angina. However, some evidence suggests that SSRIs like tricyclics, may increase risk cardiac events and death when taken for long time. New classes of antidepressants have dual reuptake inhibition for serotonin and nor-epinephrine e.g. venlafaxine. These medications are slightly more successful than SSRIs in treating depression, but they also have some adverse effects. Selegiline transdermal form was recently licensed for the treatment of MDD. Oral selegiline is not effective antidepressant. When compared to oral selegiline, STS results in stable plasma levels of drug and increased drug concentration in the brain.

Keywords

Coronary heart disease, Depression, CAD, Venlafaxine.

Full Text

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AIDS: The Long term disease

Abstract Views :101 | PDF Views:0

Authors

Sakshi. B. Chaudhari ¹, Harsha. S. Suryawanshi ¹, Azam Z. Shaikh ¹, S. P. Pawar ¹, Ritik. S. Jain ¹

Affiliations
1 Department of Pharmacology, P.S.G.V.P. M’s College of Pharmacy, Shahada. Department of Pharmacology, Ahinsa Institute of Pharmacy, Dondaicha., IN

Source

Research Journal of Pharmacology and Pharmacodynamics, Vol 14, No 3 (2022), Pagination: 155-158

Abstract

The world stands for Acquired immunodeficiency syndrome. The public understanding of AIDS as a highly critical acute illness with a rapid downward trajectory was crystallized nevertheless. In that some of advanced stages of that disease. Many countries has allowed AIDS to reach catastrophic level. AIDS is effect on mental state of injected person. The person may undergo depression. The mental health could be improved by acquisition of social support like friends and family. Provide helpful links like education, health care and social support. AIDS is sexually transmitted disease. It can be spread through person to person. AIDS is responsible for behaviour changes. Research has worked hard to compreshed the AIDS epidemic since its inception nature of the disease and its manifestation. The human immunodeficiency virus (HIV) is the causative agent (HIV). The two of them HIV-1 and HIV-2 are the most common type of HIV. The three diploid single stranded RNA genomes protease, reverse transcriptase, and viral enzyme integrates. AIDS does not have a cure. The greatest choice is prevention. Infection in blood transfusion patients of course, is a new-born (from mother). It is a malady that can only be tackled, by the social and mental fraternity acting together, to prevent the spread of the disease. There are significant continuities as well as discontinuities in the experience of living with HIV/AIDS during the last two decided, as this reveals release. The aids are sexually transmitted disease.

Keywords

HIV/AIDS, Immunodeficiency, lentiviruses.

Full Text

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Cancer: Immunology and Immunotharapy

Abstract Views :83 | PDF Views:0

Authors

Saloni S. Chhajed ¹, Mayuri V. Mali ¹, Azam Z. Shaikh ¹, S. P. Pawar ¹, Ritik. S. Jain ¹

Affiliations
1 Department of Pharmaceutics P.S.G.V.P.M’s College of Pharmacy, Shahada., IN

Source

Research Journal of Pharmacology and Pharmacodynamics, Vol 14, No 3 (2022), Pagination: 159-164

Abstract

During immune surveillance, the host provides defense versus foreign antigens. By targeting surface antigens expressed on tumor cells, monoclonal antibodies have demonstrated efficacy as cancer therapeutics. Recent successful antibody-based strategies have focused on enhancing antitumor immune responses by targeting immune cells, irrespective of tumor antigens. The use of antibodies to woodcut pathways inhibiting the endogenous immune response to cancer, known as checkpoint tampon therapy, has stirred up a unconfined deal of excitement among scientists, physicians, and patients alike. Clinical trials evaluating the safety and efficacy of antibodies that woodcut the T lamina inhibitory molecules cytotoxic T-lymphocyte various kinds of immunotherapy treatment for cancer are either misogynist to the public or are in the process of clinical trials. Immunotherapy treatments have the potential to treat cancer with significantly less toxicity than chemotherapy and radiation treatments. An accent on cellular infusion as a method of either enhancing the immune system by creating an environment for se-questering the host immune system to wade cancer cells or increasingly directly inserting cells to di-rectly wade cancer cells will be provided in this review. Various forms of cancer vaccines are moreover discussed in this paper as an important speciality in immunotherapy. This review seeks to describe various methodologies associated with overseeing immunotherapy in the treatment of cancer

Keywords

Cancer, Checkpoint tampon therapy, T-lymphocyte.

Full Text

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