Refine your search
Collections
Co-Authors
Year
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Yeshwante, S. B.
- Antiparkinsonian Effect of Cassia tora on Oxotremorine Induced Parkinson Methodology
Abstract Views :365 |
PDF Views:0
Authors
C. P. Suryawanshi
1,
V. R. Patil
1,
R. Y. Chaudhari
1,
M. K. Kale
2,
S. D. Firake
2,
R. B. Pimprikar
3,
M. D. Patil
3,
S. B. Yeshwante
3,
D. S. Saindanem
3
Affiliations
1 Tapi Valley Education Society's Hon.L.M.C. College of Pharmacy, Faizpur Dist. Jalgaon (MS), IN
2 K.Y.D.S.C.T's College of Pharmacy, Sakegaon, Tal-Bhusawal, Dist. Jalgaon 425201, IN
3 Nagaon Education Society's Gangamai College of Pharmacy, Nagaon.424005 Dist Dhule (MS), IN
1 Tapi Valley Education Society's Hon.L.M.C. College of Pharmacy, Faizpur Dist. Jalgaon (MS), IN
2 K.Y.D.S.C.T's College of Pharmacy, Sakegaon, Tal-Bhusawal, Dist. Jalgaon 425201, IN
3 Nagaon Education Society's Gangamai College of Pharmacy, Nagaon.424005 Dist Dhule (MS), IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 1, No 1 (2009), Pagination: 35-38Abstract
The Parkinson's disease is mainly distinguished from other diseases based on the key feature that is tremors. Oxotremorine induced oxidative stress is implicated as a common pathway in development of Parkinson's symptoms like, tremor, salivation and temperature variation. Hence Oxotremorine-induced tremor model was used to evaluate antiparkinsonian drugs. Different extracts of plant of Cassia tora such as, petroleum ether (200mg/kg) p.o., methanolic (200mg/kg) p.o. and ethyl acetate extract (200mg/Kg) p.o. were used to investigate antiparkinsonian effect on oxotremorine induced Parkinson's symptoms in mice. Procyclidine, an anticholinergic, antiparkinsonian drug was administered as a standard drug at a dose of 5mg/kg p.o., 1hr prior the administration of oxotremorine (0.5mg/kg) S.C. Methanolic extract at 200mg/kg p.o route of administration decreased (p<0.05) Parkinson's symptoms, while petroleum ether extract (200mg/kg)p.o and ethyl acetate extract (200mg/kg)p.o shows moderate action. This study suggests that cassia tora is a plant with possible therapeutic value for Parkinson's disease.Keywords
Parkinson's Disease, Oxotremorine, Tremor, Procyclidine.
References
- Morais LS, Quintans-junior LJ, Antiparkinsonian-like effects of Plumbago scandens on tremorine-induced tremors methodology. Pharmacol. Biochem. Behaviour. 2006; 79:745-49
- Zhenbao J, Tao F, Guo L, Guanjun T and Xiaolin D, Antioxidant properties of extracts From juemingzi (Cassia tora L.) evaluated in vitro.LWT.2007; 40: 1072-1077
- Sies H. Neurological disease: Antioxidants in Disease Mechanism and Therapy, edited by academic press Academic Press, 1997; 38: 557
- Fahn S, An Open Trial of High Dosage Antioxidants in early Parkinson's Disease. Am. J. Clin Nutr. 1991; 53: 380-382.
- Antolin I, Mayo JC, Sainz RM, Protective Effect of Melatonin in a Chronic Experimental Model of Parkinson's Disease. Brain Res. 2002; 943(2): 163-73
- LegroscinoG, Marder k, Cote L, Dietary Lipids and Antioxidants in Parkinson’s disease: a Population Based, Case-Control Study. Ann Neurol. 1996; 39: 89-94
- Yang SF, Wu Q, Sun AS, Huang XN and Shi JS, Protective Effect and Mechanism of Ginkgo Biloba Leaf Extracts for Parkinson Disease induce by 1-methyl-4-phenyl- 1, 2, 3, 6- tetrahydropyridine. Acta Pharmacol.2001; 12: 1089-93.
- Choi J S, Lee HJ and Park KY, In vitro Antimutagenic effect of Anthraquinone aglycone and napthopyrone glycosides from Cassia tora. Planta Medica.1997; 63: 11-14
- Kim YM, Lee CH, and Kim H G, Anthraquinones isolated from cassia tora seeds show an antifungal property against phytopathogenic fungi. J. Agri. Food Chem. 2004; 52: 6096- 6100
- Patil UK, Saraf S and Dixit VK, Hypolipidemic activity of seeds of cassia tora Linn. J. Ethnopharmacol. 2004; 90: 249-252
- Wu C H and Yen, GC, Antigenotoxic properties of cassia tora L: mechanism of action and the influence of roasting process. Life Science. 2004; 76: 85 -101
- Yang YC, Lim MC, and Lee HS, Emodin isolated from cassia tora shows larvicidal activity against three mosquito species. Agri. Food chem. 2003; 26: 7629- 31
- Chidume FC, Kwanashie HO and Wambebe C, Antinociceptive and muscle contracting activities of the methanolic extracts of cassia tora leaf. J. Ethnopharmacol.2002; 81: 205-209
- Vogel HG, Antiparkinsonism activity. In Drug Discovery and Evaluation, edited by Springer Verglag Berlin Heidelberg, New York. 2002; 2nd ed: pp 577-78.
- Yen GC, Duh PD and Chaung DY, Antioxidant activity of anthraquinones and anthrones. Food Chemistry. 2000; 70: 437-441
- Anti-Diarrheal Activity of Methanolic and Aqueous Extracts of Dillenia indica L
Abstract Views :209 |
PDF Views:0
Authors
S. B. Yeshwante
1,
A. R. Juvekar
1,
R. B. Pimprikar
2,
R. T. Kakade
2,
M. Tabrej
2,
M. K. Kale
3,
S. D. Firke
3
Affiliations
1 Department of Pharmacology, Institute of Chemical Technology, Matunga, Mumbai- 400019, IN
2 Gangamai College of Pharmacy, Nagaon, Dhule, IN
3 KYDSCT's College of Pharmacy, Sakegaon, Jalgaon, IN
1 Department of Pharmacology, Institute of Chemical Technology, Matunga, Mumbai- 400019, IN
2 Gangamai College of Pharmacy, Nagaon, Dhule, IN
3 KYDSCT's College of Pharmacy, Sakegaon, Jalgaon, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 1, No 3 (2009), Pagination: 140-142Abstract
The methanolic extract of Dillenia indica leaves have been reported to possess anti-inflammatory activity. Inflammatory mediators such as prostaglandins and bradykinins are involved in the pathogenesis of diarrhea. The aim of the present work was to evaluate the anti-diarrheal activity of aqueous and methanolic extracts of Dillenia indica leaves. The anti-diarrheal activity was evaluated using Castor oil induced diarrhea model and different parameters such as onset of diarrhea and total number of feaces for the period of 4 hours. were observed. The results of test group were compared with Vehicle control group using one way ANOVA followed by Dunnett's Test. The results revelaled that both extracts at doses of 200 and 400mg/kg P.O. showed significant (P<0.01) prolongation of onset of diarrhea and significant (P<0.01) reduction in total number of feaces after 2nd hour of treatment while dose of 100mg does not show any activity. From the results it can be concluded that the inhibition of the diarrhea and prolongation of onset might be due to inhibition of inflammatory mediator release and phyto-constituents such as flavonoids and tannins may have also contributed to the anti-diarrheal activity.Keywords
Dillenia indica, Dilleniaceae, Castor Oil, Aqueous and Methanolic Extracts.References
- Wendel GH, Maria AOM, Guzman JA, Giordano O, Pelzer LE. Antidiarrheal activity of dehydroleucodine isolated from Artemisia douglasiana. Fitoterapia 2008; 79: 1-5.
- Kirtikar KR, Basu BD. Indian medicinal Plants. Lalit M. and Basu, Allahabed, India.1981.
- The wealth of India- A dictionary of Indian Raw Materials and Industrial Products, Volume-III, D-E. National institute of Science communication and information research, CSIR, New Delhi; 2003.
- Shome U, Khanna RK, Sharma HP. Pharmacognostic studies on Dillenia indica Linn. II-Fruit and Seed. Proc. Indian Acad. Sci. (Plant Sci.). 1980; 89:91-104.
- Shome U, Khanna RK, Sharma HP. Pharmacognostic studies on Dillenia indica Linn. I. leaf. Proc. Indian Acad. Sci. 1979; 88: 35-48.
- Banerji N, Majumder P, Dutta NL. A new pentacyclic triterpene lactone from Dillenia indica. Phytochemistry. 1975; 12: 1447-1448.
- Pavanasasivam G, Suktanbawa MU. Flavonoids of some Dilleniaceae species. Phytochemistry. 1975; 14: 1127-1128.
- Abdille MH, Singh RP, Jayaprakash GK, Jena BS. Antioxidant activity of the extracts from Dillenia indica fruits. Food chemistry. 2005; 90: 891-896.
- Yeshwante SB, Juvekar AR, Nagmoti DM, Wankhede SS, Shah AS, Pimprikar RB, Saindane DS. Anti-inflammatory activity of methanolic extract of Dillenia indica L. Leaves. J. Young. Pharmacists. 2009;1:63-66.
- Bhakuni DS, Dhar ML, Dhar MM, Dhawan BN, Mehrotra BN. Screening of Indian plants for biological activity Pt. II. Ind J Exp bio. 1968; 7: 250-262.
- O.O. Adeyemi OO, Akindele AJ. Antidiarrhoeal activity of the ethyl acetate extract of Baphia nitida (Papilionaceae). J. Ethnopharmacol. 2008;116: 407-412.
- Rang HP, Dale MM, Ritter JM. Textbook of Pharmacology. UK: Churchill Livingstone; 1999
- Mukherjee PK, Saha K, Murugesan T, Mandal SC, Pal M, Saha BP. Screening of anti-diarrhoeal profile of some plant extracts of a specific region of West Bengal, India. J. Ethnopharmacol. 1998;60:85-89
- Capasso F, Mascolo N, Izzo AA, Gaginella TS. Dissociation of castor oil-induced diarrhoea, and intestinal mucosal injury in rat: effect of NG-nitro-L-arginine methyl ester. Br. J. Pharmacol. 1994;113:1127-1130.
- Mbagwu HOC, Adeyemi OO. Anti-diarrhoeal activity of the aqueous extract of Mezoneuron benthamianum Baill (Caesalpiniaceae). J. Ethnopharmacol. 2008;116:16-20.