Research Journal of Pharmacology and Pharmacodynamics

N. B. Sridharamurthy ¹, R. Yogananda ², Riyaz Mahamood ³

Affiliations
1 Department of Pharmacology, Dayanandsagar College of Pharmacy, Shavige Malleshwara Hills, Kumarswamy Layout, Banglore, Karnataka, 560078, IN
2 Department of Pharmaceutics, SJM college of Pharmacy, Chitradurga, Karnataka, IN
3 Department of Biotechnology, Kuvempu University, Shimoga, Karnataka, IN

Abstract

A mixture of Xanthine, Xanthone and Xanthosine isolated from the ischolar_main of Xanthium strumarium L exhibited antitumor activities against Ehrlich Ascites Carcinoma in Swiss albino mice. Animals were pre-treated orally with the extract at a dose of 200mg/kg, 25 and 50mg/kg body weight for isolated compounds of chloroform extract and then after 24hrs EAC (at a dose of 2×10⁶ cells/mouse) administration and following an 18hr fasting; mice were sacrificed for studying of antitumor activity. The decrement of tumor volume, packed cell volume and viable cell count were observed in both lignans and isolated compounds of chloroform extract treated animals and compared with only EAC tumor bearing mice. Treatment with test compounds increased the survival time and normal peritoneal cell count. Hematological parameters, PCV which were altered by tumor volume inoculation, were restored considerably. Thus, this study was an attempt to evaluate the preventive and curative role of X. strumarium lignans in tumor bearing mice.

Keywords

Ehrlich Ascites Carcinoma, Xanthium strumarium, Lignans, Xanthone, Xanthine and Xanthosine.

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