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Venkatanarayanan, R.
- Pharmacological Evaluation of Antiasthmatic Activity of Tamarindus indica Seed
Abstract Views :302 |
PDF Views:1
Authors
R. Suresh
1,
Ganesh Pandhari Mhaske
2,
Nehru Sai Suresh Chalichem
2,
Ashok Kumar Javvadi
2,
D. Benito Johnson
2,
R. Venkatanarayanan
2
Affiliations
1 Department of Pharmacology, R. V. S. College of Pharmaceutical Science, 242, Trichy Road Sulur, Coimbatore-641 402., IN
2 Department of Pharmacology, R. V. S. College Pharmaceutical Science, Sulur, Coimbatore-641 402, IN
1 Department of Pharmacology, R. V. S. College of Pharmaceutical Science, 242, Trichy Road Sulur, Coimbatore-641 402., IN
2 Department of Pharmacology, R. V. S. College Pharmaceutical Science, Sulur, Coimbatore-641 402, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 3, No 3 (2011), Pagination: 115-122Abstract
Practical experience and several modern research studies have shown that therapy using plant is better than using synthetic chemicals. According to ayurvedic folklore the Tamarindus indica Linn was mentioned for several ailments including asthma (kirtikar et al; 2001) the present study was planned to know the anti asthmatic activity of methanolic extract of this plant at different stages or different types of asthma using various evaluation models like, isolated goat tracheal chain preparation, bronchial hyperactivity, clonidine induced catalepsy in guinea pig, mast cell degranulation, milk induced leucocytosis in mice, milk induced eosinophilia in mice, passive paw anaphylaxis, and its activities such as bronchodilating, antihistaminic, anti inflammatory , anti allergic, mast cell stabilizing and adaptogenic activities were confirmed presenting the scope of plant for further studies. The data was analyzed by student't' test or one way ANOVA followed by Dunnett test. P≤0.05 was considered as significant.Keywords
Tamarindus Indica Linn., Catalepsy, Leukocytosis, Anaphylaxis, Degranulation.
References
- Wardlaw et al.,.New insight into the relation between airway inflammation and asthma. Clinical science, 2002; 103: 201-11.
- Oliver N, Gerald h, and Gert K,. Immunological and clinical changes in allergic asthmatics following treatment with omalizumab. Int Arch Allergy Immunol.2003;131: 46-52.
- Ryland P.B., Guha K, and Thomas M.R.,. Difficult to management of Asthma. Post graduate medicine. 2000; 108(6): 2-11.
- Casstillo.J.C. De-Beer, E.J., 1947. The tracheal chain-1. A preparation for the study of antispasmodics with particular reference to bronchodilator drugs. J. Pharmacol. Exp. Ther. 1947;90: 104-109.
- Kulshrestha, S., Misra, S.S, Sharma A.L., Sharma, L., Singhal, D.,. Response of the goat trachea to some autonomic drugs. Ind. J. Pharmacol.1983; 15(2): 107-109.
- Naj chaudhary, A.K., Lahari, S.C.,. Use of goat trachea isolated tracheal chain preparation. Ind. J. Pharmacol. 1974;6: 149-51.
- Ghosh, M.N. Fundamental of Experimental Pharmacology Scientific Book Agency Calcutta, 1984; 2nd ed., p.115-21.
- Singh, S., Majumdar, D.K.,. Anti-inflammatory activity of cium sancyum oil and Flax seed oil. Ind J Exp Biol. 1990;35:380-383.
- Tripathi R.M., Das, P.K.. Studies on Antiasthmatic and Antianaphylactic activity of Albizzia lebbeck. Ind. J. Pharmacol. 1977;9(3): 189-194.
- Mitra, S.K. Antiasthmatic and Antianaphylactic effect of E-721B, an herbal formulation, Ind. J. Pharmacol. 1999; 31: 133-137.
- Jadhav, J.H., Balsara J.J., Chandorkar,A.G. Involvement of histaminergic mechanisms in cataleptogenic effect of clonidine in the mice. J.Pharm.Pharmacol 1983;35:671-73.
- Muley, M.P., Balsara, J.J., Chandorkar. Effect of L-histidine pretreatment on haloperidol induced catalepsy and methamphetamine stereotype in mice. Ind. J. Pharmacol, 1983;1164: 293-300.
- Schwartz, J.C.. Annual review of Pharmacology and Toxicological; edited by Elliot, H.W., George, R., Okun,R., Ann. Reviews. Inc., Palo Alto. 1997; 4th ed., 325-339.
- Balsara, J.J., Chandorkar, A.G., Jadhav, J.H. Involvement of histaminergic mechanisms in the cataleptogenic effect of clonidine in mice. Journal of Pharm. Pharmacol 1983;35:671-83.
- Ferre, S., Guix, T., Prat,G., Jane,F., Casas, M. Is experimental catalepsy properly measured pharmac Biochem Behav 1990;35:753-7.
- Uvnas, B. Mast cells and Histamine release. Indian J Pharmacol. 1969; 1 (2): 23-25.
- Geetha, V.S., Viswanathan, S., Kameswaran, L. Comparision of total alkaloids of Tylophora indica and Disodium cromoglycate on mast cell stabilization. Indian J Pharmacol 1981;13: 199-201.
- Lakdawala, A.D., Dadkar, N.K., Dohadwala A.N. Action of clonidine on the mast cells of rats. J. Pharm. Pharmacol. 1980; 32: 790-791.
- Brekhman,I.I., Dardymov.I.V. New substances of plant origin which increases non specific resistance.Ann.Rev.Pharmac. 1969;9: 419-430.
- Brigden, M.L.. A Practical Workshop For Eosinophilia Postgraduate Med. 1999;3: 105-15.
- Ehright,T., chua,S., Lim, D.J.. Pulmonary eosinophilic syndromes. Ann.Allergy. 1989;62: 277-83.
- Bhargava. K.P., Singh, N. Antistress activity of ocimum sanctum. Indian Journal of Medical Research 1981;73: 443-451.
- Ghai,A.. A textbook of Practical Physiology1987;3rd ed., Jaypee Brothers Delhi. 9.191-92.
- Gokhale,A.B., Saraf, M.N. Bronchoprotective effect of methanolic extract of Tephrosia purpurea in vivo. Indian Drugs 1996; 37(7): 346-347.
- Cua-Lim, F.. Immunological aspects of asthma: Therapeutic implications.1984;2: 15-26.
- Kulkarni, S.K. Biological Distribution of Histamine Receptors. Indian J.Pharmacol 1976; 9(3): 157-159.
- Mengi S, Pungle P, Banavalikar M, and Suthar A. Immunomodulatory activity of bosweliic acids of Boswellia sarrata Roxb. Indian J Exp Biol. 2003;41: 1460-62.
- Anti-Inflammatory Activity Screening of Methanolic Extract of Bryophyllum pinnatum Root
Abstract Views :79 |
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Authors
Affiliations
1 Department of Pharmacology, RVS College of Pharmaceutical Sciences, Sulur, Coimbatore – 641402., IN
2 Department of Pharmacy Practice, RVS College of Pharmaceutical Sciences, Sulur, Coimbatore – 641402., IN
3 Department of Pharmacognosy, RVS College of Pharmaceutical Sciences, Sulur, Coimbatore – 641402., IN
1 Department of Pharmacology, RVS College of Pharmaceutical Sciences, Sulur, Coimbatore – 641402., IN
2 Department of Pharmacy Practice, RVS College of Pharmaceutical Sciences, Sulur, Coimbatore – 641402., IN
3 Department of Pharmacognosy, RVS College of Pharmaceutical Sciences, Sulur, Coimbatore – 641402., IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 14, No 1 (2022), Pagination: 1-3Abstract
An inflammatory response appears after activation of immune response. Inflammation is a response to remove the primary cause of cell injury. Dead cells, damage tissue sand initiate the repair process. Inflammation may be of two types acute and chronic. Medicinal plants has a potential source of therapeutic aid has a attended a significant role in all over the world for both human and animals not only in the disease condition but also a potential for maintaining a proper health. The plant Bryophyllum pinnatum species (roots) are evaluated for anti-inflammatory activity. Aim: Anti-inflammatory activity of Bryophyllum pinnatum was evaluated using Carrageenan induced paw oedema, Histamine induced paw oedema and Egg white induced paw oedema. Materials and Methods: To prepare methanolic extracts of Bryophyllum pinnatum roots and investigate the anti-inflammatory activity by Carrageenan induced paw oedema, Histamine induced paw oedema and Egg white induced paw oedema. Result: The result obtained indicates that the extract found to have significant (p<0.0001) anti-inflammatory activity in rats. The extract at the test doses 200mg/kg reduced the oedema induced by carrageenan by 41.26% at 3 h, whereas the standard drug showed 47.35% of inhibition ass compared to the control group. Conclusion: The methanolic extract of Bryophyllum pinnatum are safe upto 500mg/kg for continues administration and it can be used as anti inflammatory agent without any harmful effectsKeywords
Inflammation, Oedema, Therapeutic aid, anti-inflammatory activity, Histamine.References
- Text book of pathology by Harsh Mohan 6th edition p.no131.
- Abbas A.B.; Lichtman A.H (2009). “Ch.2 Innate Immunity”. In Saunders (Elsevier).
- Stedman‟s Medical University Dictionary (Twenty-fifth ed.). Williams and wilkins. (1990)
- Latif A, Ashiq K, Ashiq S, Ali E, Anwer I, Qamar S. Phytochemical analysis and in vitro investigation of antiinflammatory and xanthine oxidase inhibition potential of root extracts of Bryophyllum pinnatum. J Anim Plant Sci. 2020 Feb 1;30(1):219-28.
- Mudi SY, Ibrahim H. Activity of Bryophyllum pinnatum S. Kurz extracts on respiratory tract pathogenic bacteria. Bayero Journal of Pure and Applied Sciences. 2008:39-42.
- KouitcheuMabeku LB, Eyoum Bille B, Tchouangueu TF, Nguepi E, Leundji H. Treatment of Helicobacter pylori infected mice with Bryophyllum pinnatum, a medicinal plant with antioxidant and antimicrobial properties, reduces bacterial load. Pharmaceutical Biology. 2017 Jan 1;55(1):603-10.
- Salami EO, Ozolua RI, Okpo SO, Eze GI, Uwaya DO. Studies on the anti-asthmatic and antitussive properties of aqueous leaf extract of Bryophyllum pinnatum in rodent species. Asian Pacific Journal of Tropical Medicine. 2013 Jun 1;6(6):421-5.
- Ogidi OI, Esie NG, Dike OG. Phytochemical, Proximate and Mineral compositions of Bryophyllum pinnatum (Never die) Medicinal plant. Journal of Pharmacognosy and Phytochemistry. 2019;8(1):629-35.
- Nwali BU, Okaka ANC, Ibiam UA, Aja PM. Phytochemical composition of Bryophyllum pinnatum Leaves. International Journal of Advanced Biological Research. 2012; 2(4):614- 616.
- Okwu DE, Nnamdi FU. Two novel flavonoids from Bryophyllum pinnatum and their anti microbial Activity. Journal of Chemical and Pharmaceutical Research. 2011; 3(2):1-10.
- Ncube NS, Afolayan AJ, Okoh AI. “Assessment techniques of antimicrobial properties of natural compounds of plant origin: current methods and future trends”, African J. Biotec. 2008; 7 (12): 1797-1806