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Kakade, R. T.
- Anti-Diarrheal Activity of Methanolic and Aqueous Extracts of Dillenia indica L
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Authors
S. B. Yeshwante
1,
A. R. Juvekar
1,
R. B. Pimprikar
2,
R. T. Kakade
2,
M. Tabrej
2,
M. K. Kale
3,
S. D. Firke
3
Affiliations
1 Department of Pharmacology, Institute of Chemical Technology, Matunga, Mumbai- 400019, IN
2 Gangamai College of Pharmacy, Nagaon, Dhule, IN
3 KYDSCT's College of Pharmacy, Sakegaon, Jalgaon, IN
1 Department of Pharmacology, Institute of Chemical Technology, Matunga, Mumbai- 400019, IN
2 Gangamai College of Pharmacy, Nagaon, Dhule, IN
3 KYDSCT's College of Pharmacy, Sakegaon, Jalgaon, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 1, No 3 (2009), Pagination: 140-142Abstract
The methanolic extract of Dillenia indica leaves have been reported to possess anti-inflammatory activity. Inflammatory mediators such as prostaglandins and bradykinins are involved in the pathogenesis of diarrhea. The aim of the present work was to evaluate the anti-diarrheal activity of aqueous and methanolic extracts of Dillenia indica leaves. The anti-diarrheal activity was evaluated using Castor oil induced diarrhea model and different parameters such as onset of diarrhea and total number of feaces for the period of 4 hours. were observed. The results of test group were compared with Vehicle control group using one way ANOVA followed by Dunnett's Test. The results revelaled that both extracts at doses of 200 and 400mg/kg P.O. showed significant (P<0.01) prolongation of onset of diarrhea and significant (P<0.01) reduction in total number of feaces after 2nd hour of treatment while dose of 100mg does not show any activity. From the results it can be concluded that the inhibition of the diarrhea and prolongation of onset might be due to inhibition of inflammatory mediator release and phyto-constituents such as flavonoids and tannins may have also contributed to the anti-diarrheal activity.Keywords
Dillenia indica, Dilleniaceae, Castor Oil, Aqueous and Methanolic Extracts.References
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- Overview on Acquired Immunodeficiency Syndrome
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Authors
Affiliations
1 NGSPMs College of Pharmacy, Anjaneri, Nashik, Maharashtra, IN
2 H.R. Patel Institute of Pharmaceutical Education and Research, Shirpur, Maharashtra, IN
1 NGSPMs College of Pharmacy, Anjaneri, Nashik, Maharashtra, IN
2 H.R. Patel Institute of Pharmaceutical Education and Research, Shirpur, Maharashtra, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 4, No 3 (2012), Pagination: 158-162Abstract
Acquired immunodeficiency syndrome (AIDS) causes an irreversible destruction of immune system. Currently, used drugs for treatment of HIV/AIDS act through inhibition of important viral enzymes such as reverse transcriptase, protease and/or integrase. Uncoating inhibitor has also been approved for treatment of AIDS with novel mode of action. However, it is now evident that the existing armoury of antiretroviral and even their triplet (cocktail) and/or quadruple (highly active antiretroviral therapy, HAART), will not lead to eradication of HIV infection. Therefore recently scientists have proposed different targets and treatment approaches towards the HIV/AIDS, which include entry inhibitors, transcription inhibitors, uncoating inhibitors, zinc finger inhibitors, gene therapy.Keywords
AIDS, Life Cycle, Recent Targets.References
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