Refine your search
Collections
Co-Authors
Year
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Agrawal, R. C.
- Chemopreventive Potential of Aegle marmelos Fruit Extract against 7,12-dimethylbenz(a)Anthracene-Induced Skin Papillomagenesis in Mice
Abstract Views :245 |
PDF Views:0
Authors
Affiliations
1 Jawaharlal Nehru Cancer Hospital and Research Centre, Idgah hills, Bhopal (MP), IN
2 Deptt. of Biosciences, Barkatullah University, Bhopal (MP), IN
3 Columbia Institute of Pharmacy, Raipur, IN
1 Jawaharlal Nehru Cancer Hospital and Research Centre, Idgah hills, Bhopal (MP), IN
2 Deptt. of Biosciences, Barkatullah University, Bhopal (MP), IN
3 Columbia Institute of Pharmacy, Raipur, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 4, No 2 (2012), Pagination: 87-90Abstract
The present investigation was undertaken to explore the chemopreventive action of Aegle marmelos fruit extract on 2-stage carcinogenesis, induced by a single topical application of 7, 12-Dimethylbenz(a)anthracene (DMBA) (104μg/100μl acetone), and one week later, promoted by repeated application of croton oil (1% in acetone/twice in a week) till the end of the experiment (16 weeks) in Swiss albino mice. Single topical application of Aegle marmelos fruit extract at a dose of 900 mg/kg b.w. along with DMBA+Croton oil was found to be effective in decreasing the cumulative number of papillomas, tumor incidence, tumor yield and tumor burden as compared to control group (p<0.05). The depleted levels of glutathione were also restored in Aegle marmelos fruit extract treated group. Thus, the present study revealed the chemopreventive role of Aegle marmelos fruit extracts against DMBA-induced skin carcinogenesis in mice.Keywords
Chemopreventive, Aegle marmelos, DMBA, Papilloma, Skin Carcinogenesis, Glutathione.
References
- Arul V, Miyazaki S and Dhananjayan R (2005): Studies on the anti-inflammatory, antipyretic and analgesic properties of the leaves of Aegle marmelos Correa. Journal of Ethnopharmacology, 96(1), 159- 163.
- Arumugam S, Kavimani S, Kadalmani B, Ahmed ABA, Akbarsha MA, Rao MV (2008): Antidiabetic activity of leaf and callus extracts of Aegle marmelos in rabbit. Science Asia, 34, 317-321.
- Ather M (2002): Oxidative stress and experimental carcinogenesis. Indian J Exp Biol, 40, 656-667.
- Agrawal RC, Jain R, Raja W and Ovais M (2009): Anticarcinogenic effects of Solanum lycopersicum fruit extract on Swiss albino and C57BL mice. Asian Pacific Journal of Cancer prevention, 10(1-4), 379-382.
- Berenblum I and Shubik P (1947): A new quantitative approach to the study of stages of Chemical carcinogenesis in the mouse skin. Brit J Cancer, 1, 383-387.
- Berenblum I (1975): Sequqntial aspects of chemical carcinogenesis: skin in cancer “A comprehensive treatise”. Plenum Press, New York, 1, 323-344.
- Beutler E, Duron O, Kellin BM (1963): Improved method for the determination of blood glutathione. Journal of Laboratory and Clinical Medicine, 61, 882-888.
- Brijesh S, Daswani P, Tetali P, Anita N, Birdi T (2009): Studies on the antidiarrhoeal activity of Aegle marmelos unripe fruits: Validating its traditional usage. BMC complementary and Alternative medicine, 9(47), 1-12.
- Bystrianyk R (2005): Aloe helps block cancer. J Toxicol Environ health, 17, 45-49.
- Chaudhary G, Saini MR, Goyal PK (2007): Chemopreventive potential of Aloe vera against 7, 12-dimethylbenz(a)anthracene induced skin papillomagenesis in mice. Integrative cancer Therapies, 6(4), 405-412.
- Copeland ES (1983): A national institute of health workshop report. Free radical in promotion. A chemical pathology study section workshop. Cancer Research, 43, 5631-5637.
- Jagetia GC, Venkatesh P, Baliga MS (2005): Aegle marmelos (L.) Correa Inhibits the proliferation of Transplanted Ehrlich Ascites Carcinoma in mice. Biol. Pharm. Bulletin, 28(1), 58-64.
- Lampronti I, Martello D, Bianchi N, Borgatti M, Lambertini E, Piva R, Jabbar S, Choudhari MS, Khan MT, Gambari R (2003): Antiproliferative effects on human tumor cell lines of extracts from the Bangladeshi medicinal plant Correa. Phytomedicine, 10(4), 300-308.
- Moron MS, Depierre JW and Mannervik B (1979): Levels of Glutathione, Glutathione Reductase and Glutathione-s-transferase activities in rat lung and liver. Biochimica et Biophysica Acta, 582, 67-78.
- Morse EC, Stoner G (1996): Cancer chemoprevention: principles and prospects. Carcinogenesis, 14, 1737-1746.
- Lewis JG and Adams DO (1987): Early inflammatory changes in the skin of Sencer and C57B2/6 mice following exposure to 12-Otetradecanoyl phorbol-13-acetate. Carcinogenesis, 8, 889-898.
- Nugroho AE, Riyanto S, Sukari MA, Maeyama K (2010): Effects of Skimmianine, a quinoline alkaloid of Aegle marmelos Correa ischolar_mains, on the Histamine release from rat mast cells. Journal of Basic and applied Sciences, 6(2), 141-148.
- Oberley TD and Oberley LW (1993): Oxygen radicals and cancer. In free radicals in Ageing' EdYuBP, CRC Press, Boca Raton, FL, pg-247-267.
- Narendra T, Shweta S, Tiwari P, Reddy KP, Khaliq T, Prathipati P, Puri A, Srivastava AK, Chander R, Agarwal SC, Raj K (2007): Antihyperglycemic and antidyslipidemic agent from Aegle marmelos. Bioorg Med Chem Letters, 17(6), 1808-1811.
- Meena PD, Kaushik P, Shukla S, Soni AK, Kumar M, Kumar A (2006): Anticancer and antimutagenic properties of Acacia nilotica (Linn) on 7, 12-dimethylbenz(a)anthracene induced skin papillomagenesis in Swiss Albino mice. Asian pacific Journal of cancer prevention, 7, 627-632.
- Sabu MC and Kuttan R (2004): Antidiabetic activity of Aegle marmelos and its relationship with its antioxidant properties. Indian J. Physiol Pharmacology, 48(1), 81-88.
- Samarasekera I and Krishnamurti JK (2004): Isolation of various coumarin present in the various parts of the Aegle marmelos. Nat. Prod. Res., 18(2), 117-132.
- Singanan V, Singanan M and Begum H (2007): The hepatoprotective effect of Bael leaves (Aegle marmelos) in alcohol induced liver injury in Albino rats. International Journal of Science and Technology, 2(2), 83-92.
- Upadhya S, Shanbhag KK, G Suneetha, Naidu, Upadhya S (2004): A study of Hypoglycemic and antioxidant activity of Aegle marmelos in Alloxan induced diabetic rats. Indian Journal of Physiol Pharmacology, 48(4), 476-480.