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Ashok, Purnima
- Hepatoprotective and Antioxidant Potential of Calotropis gigantea in Cyclosporine-An Induced Hepatotoxicity
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Authors
Ajay Kshirsagar
1,
Deepa Ingawale
2,
Purnima Ashok
3,
Vrushali Thorve
2,
Tanmay Dodal
2,
Anurag Dodal
2,
Mahesh Kahane
2,
Bharat Zope
2
Affiliations
1 Pad. Dr. D. Y. Patil Institute of Pharmaceutical sciences and research, Pimpari, Pune-411 018, India, IN
2 AISSMS College of Pharmacy, Near RTO, Kennedy road, Pune-411 001, IN
3 Department of Pharmacology, K.L.E.S's College of Pharmacy, Bangalore-560010, IN
1 Pad. Dr. D. Y. Patil Institute of Pharmaceutical sciences and research, Pimpari, Pune-411 018, India, IN
2 AISSMS College of Pharmacy, Near RTO, Kennedy road, Pune-411 001, IN
3 Department of Pharmacology, K.L.E.S's College of Pharmacy, Bangalore-560010, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 2, No 5 (2010), Pagination: 343-347Abstract
The ethanolic fraction of Calotropis gigantea flowers (CGFE) was evaluated for its possible hepatoprotective potential in Wistar rats. The CGFE (250mg/kg and 500mg/kg, bw p.o.) showed a remarkable hepatoprotective activity against cyclosporine-A induced hepatotoxicity as judged from the level of serum markers for liver damage. Cyclosporine-A induced a significant rise in serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP) and lipid profile levels. The cotreatment of animals with CGFE (250mg/kg and 500mg/kg, p.o.) significantly decreased the elevated serum marker enzyme and lipid profile levels near to normal. The activity of the CGFE was comparable to the standard drug, silymarin (100mg/kg, p.o.). Further histopathological studies support the above finding.Keywords
Antioxidant, Calotropis gigantea, Cyclosporine-A, Hepatotoxicity.
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